Výsledky vyhledávání - "Michal L Schwartzman"

Carbohydrate-Restricted Diet: A Successful Strategy for Short-Term Management in Youth with Severe Obesity—An Observational Study

Autor: Mark Castle, Meghan Pauley, Chadd Mays, Lars Bellner, Marji McCoy, Michal L. Schwartzman, Deborah L. Preston, Casey Patick, Matthew Nudelman, Joseph Werthammer, James R. Bailes, Krista L. Denning

Publikováno v: Metabolic Syndrome and Related Disorders. 19:281-287

Background: Obesity affects ∼20% of children in the United States and reports of successful dietary treatment are lacking. This study aimed to determine the change in body weight in severely obese ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd42111603139a3ef9f46d48b2fb179
https://doi.org/10.1089/met.2020.0078

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Akademický článek

Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes

Autor: Dong Hyun Kim, Nitin Puri, Komal Sodhi, John R. Falck, Nader G. Abraham, Joseph Shapiro, Michal L. Schwartzman

Publikováno v: Journal of Lipid Research, Vol 54, Iss 3, Pp 786-793 (2013)

20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), a product of the cytochrome P450 (CYP)-catalyzed ω-hydroxylation of arachidonic acid, induces oxidative stress and, in clinical studies, is associated with increased body mass index (BMI) and the

Externí odkaz: https://doaj.org/article/ea4da110cc7048e3b58ba57d48cd3ee4

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Proximal tubule-targeted overexpression of the Cyp4a12-20-HETE synthase promotes salt-sensitive hypertension in male mice

Autor: Victor Garcia, Varunkumar Pandey, Michal L. Schwartzman, Sakib Hossain, Sharath Kandhi, Kevin Agostinucci, Alberto Nasjletti, Ankit Gilani, Jonathan V. Pascale

Publikováno v: Am J Physiol Regul Integr Comp Physiol

20-Hydroxyeicosatetraenoic acid (20-HETE) has been linked to blood pressure (BP) regulation via actions on the renal microvasculature and tubules. We assessed the tubular 20-HETE contribution to hypertension by generating transgenic mice overexpressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60585fe360a8ea549435ac1a68c221e
https://doi.org/10.1152/ajpregu.00089.2020

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Uncovering the signalling, structure and function of the 20-HETE-GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75

Autor: Victor Garcia, Adeniyi Michael Adebesin, Jonathan V. Pascale, John R. Falck, Michal L. Schwartzman, Eon Joo Park

Publikováno v: Br J Pharmacol

BACKGROUND AND PURPOSE: The G-protein-coupled receptor GPR75 (Gq) and its ligand, the cytochrome P450-derived vasoactive eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), are involved in the activation of pro-inflammatory and hypertensive signall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d237b2f09c4750aff4662e1bc83c73
https://pubmed.ncbi.nlm.nih.gov/33974269

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EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension

Autor: Michal L. Schwartzman, Kelsey Wackman, Jing Wu, Justin L. Grobe, Sergey Dikalov, Curt D. Sigmund, Shi Fang, Ko-Ting Lu

Publikováno v: Hypertension

We previously showed that impaired vasodilation in systemic and renal vessels contributes to salt-sensitive hypertension in a mouse model of impaired PPARγ (peroxisome proliferator-activated receptor gamma) function. We determined the mechanisms med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c169b64073210950898503771b6114
https://pubmed.ncbi.nlm.nih.gov/33641369

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IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging

Autor: Michal L. Schwartzman, Priya Balasubramanian, Anna Csiszar, Ádám Nyúl-Tóth, Tamas Kiss, Anna Ungvari, Stefano Tarantini, Nicole M. Ashpole, Zoltan Ungvari, Zoltán Benyó, Andriy Yabluchanskiy, Sreemathi Logan, William E. Sonntag

Publikováno v: GeroScience

Aging is associated with a significant deficiency in circulating insulin-like growth factor-1 (IGF-1), which has an important role in the pathogenesis of age-related vascular cognitive impairment (VCI). Impairment of moment-to-moment adjustment of re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0574e912fe6c65b64767870d3ae9ada

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Abstract 15873: Novel Contributions of Neutrophil-derived Myeloperoxidase and Hypochlorous Acid to 20-hydroxyeicosatetraenoic Acid Production That Drives Post-ischemic Angiogenesis

Autor: Juan A. Azcona, Austin M. Guo, Michal L. Schwartzman, Thomas M. Jeitner, Samantha Tang

Publikováno v: Circulation. 142

Introduction: Compensatory angiogenic response to ischemia is often insufficient in maintaining adequate tissue perfusion resulting in critical limb ischemia and amputation. Identifying a novel mechanism by which angiogenesis occurs in these conditio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05efdba813f44081cd6808007bac8306
https://doi.org/10.1161/circ.142.suppl_3.15873

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