Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Michal Kroupa"'
Autor:
Michal Kroupa, Ondrej Kubecek, Kristyna Tomasova, Petr Hanak, Marketa Krupova, Klara Cervena, Anna Siskova, Jachym Rosendorf, Petr Hosek, Ludmila Vodickova, Pavel Vodicka, Vaclav Liska, Stanislav John, Veronika Vymetalkova, Jiri Petera
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length (TL) dynamics in prima
Externí odkaz:
https://doaj.org/article/e208be7268cb49858512e83c538d6774
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/98d10af52f1247339d7804364acd10e1
Autor:
Kristyna Tomasova, Michal Kroupa, Alzbeta Zinkova, Marie Korabecna, Veronika Vymetalkova, Pavel Skrobanek, Ladislav Sojka, Miroslav Levy, Kari Hemminki, Vaclav Liska, Petr Hosek, Rajiv Kumar, Ludmila Vodickova, Pavel Vodicka
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
We investigated the possible associations between leukocyte telomere length, therapy outcomes, and clinicopathological features in patients with colorectal cancer. Additionally, telomerase reverse transcriptase (TERT) expression was evaluated. Telome
Externí odkaz:
https://doaj.org/article/27f640ec3509491cafcef88e4739676b
Autor:
Michal Kroupa, Kristyna Tomasova, Miriam Kavec, Pavel Skrobanek, Tomas Buchler, Rajiv Kumar, Ludmila Vodickova, Pavel Vodicka
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Telomeres are complex protective structures located at the ends of linear eukaryotic chromosomes. Their purpose is to prevent genomic instability. Research progress in telomere biology during the past decades has identified a network of telomeric tra
Externí odkaz:
https://doaj.org/article/62b41bcb715b4e7fbf4ee3be041aeaf4
Autor:
Yasmeen Niazi, Hauke Thomsen, Bozena Smolkova, Ludmila Vodickova, Sona Vodenkova, Michal Kroupa, Veronika Vymetalkova, Alena Kazimirova, Magdalena Barancokova, Katarina Volkovova, Marta Staruchova, Per Hoffmann, Markus M. Nöthen, Maria Dusinska, Ludovit Musak, Pavel Vodicka, Kari Hemminki, Asta Försti
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
DNA damage and unrepaired or insufficiently repaired DNA double-strand breaks as well as telomere shortening contribute to the formation of structural chromosomal aberrations (CAs). Non-specific CAs have been used in the monitoring of individuals exp
Externí odkaz:
https://doaj.org/article/67c08dd2adc745f7a352ef04e03c4aa4
Autor:
Miriam J. Kavec, Marketa Urbanova, Pavol Makovicky, Alena Opattová, Kristyna Tomasova, Michal Kroupa, Klara Kostovcikova, Anna Siskova, Nazila Navvabi, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova, Pavel Vodicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5704 (2022)
Oxidative stress, oxidative DNA damage and resulting mutations play a role in colorectal carcinogenesis. Impaired equilibrium between DNA damage formation, antioxidant status, and DNA repair capacity is responsible for the accumulation of genetic mut
Externí odkaz:
https://doaj.org/article/df5a938844314a999f3a9b6f54b5dd40
Autor:
Pavel Vodicka, Marketa Urbanova, Pavol Makovicky, Kristyna Tomasova, Michal Kroupa, Rudolf Stetina, Alena Opattova, Klara Kostovcikova, Anna Siskova, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2473 (2020)
Oxidative stress with subsequent premutagenic oxidative DNA damage has been implicated in colorectal carcinogenesis. The repair of oxidative DNA damage is initiated by lesion-specific DNA glycosylases (hOGG1, NTH1, MUTYH). The direct evidence of the
Externí odkaz:
https://doaj.org/article/975e3a4273b44b248fc1687c4e478c17
Autor:
Ludmila Vodickova, Andrea Cumova, Sivaramakrishna Rachakonda, Pavel Soucek, Rajesh Kumar, Sona Vodenkova, Michal Kroupa, Andrea Rossnerova, Kari Hemminki, Vaclav Liska, Veronika Vymetalkova, Kristyna Tomasova, Pavel Vodicka
Publikováno v:
Mutagenesis. 35:491-497
Disruption of telomere length (TL) homeostasis in peripheral blood lymphocytes has been previously assessed as a potential biomarker of breast cancer (BC) risk. The present study addressed the relationship between lymphocyte TL (LTL), prognosis and c
Telomere maintenance in interplay with DNA repair in pathogenesis and treatment of colorectal cancer
Publikováno v:
Mutagenesis. 35:261-271
Colorectal cancer (CRC) continues to be one of the leading malignancies and causes of tumour-related deaths worldwide. Both impaired DNA repair mechanisms and disrupted telomere length homeostasis represent key culprits in CRC initiation, progression
Autor:
Kristyna Tomasova, Michal Kroupa, Anna Siskova, Josef Horak, Ondrej Vycital, Vaclav Liska, Ludmila Vodickova, Pavel Vodicka
Publikováno v:
Cancer Research. 82:2316-2316
Telomere attrition is a well-known hallmark of malignancy in cancer tissue. Our study analyzed the relative telomere length in adenomas, precursor lesions of colorectal adenocarcinoma. We investigated if the accelerated telomere length shortening occ