Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michal Kopcial"'
Publikováno v:
Molecules, Vol 24, Iss 10, p 1899 (2019)
The mRNA 5′ cap consists of N7-methylguanosine bound by a 5′,5′-triphosphate bridge to the first nucleotide of the transcript. The cap interacts with various specific proteins and participates in all key mRNA-related processes, which may be of
Externí odkaz:
https://doaj.org/article/a10fc89ddea24596ae9b70a3e5af7f30
Autor:
Miroslaw Smietanski, Mateusz Fido, Victoria H. Cowling, Adam Mamot, Jacek Jemielity, Joanna Kowalska, Renata Kasprzyk, Przemyslaw Wanat, Michal Kopcial
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
In eukaryotes, mature mRNA is formed through modifications of precursor mRNA, one of which is 5' cap biosynthesis, involving RNA cap guanine-N7 methyltransferase (N7-MTase). N7-MTases are also encoded by some eukaryotic viruses and facilitate their r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ff6eb0421ccd225ae9c55682b4c5ff
https://doi.org/10.1002/chem.202001036
https://doi.org/10.1002/chem.202001036
Autor:
Joanna Kowalska, Jacek Jemielity, Renata Kasprzyk, Michal Kopcial, Dominika Strzelecka, Przemyslaw Wanat, Pawel J. Sikorski
Publikováno v:
Chemical Communications. 54:9773-9776
We describe a new type of nucleotide-derived fluorescent probe designed for monitoring pyrophosphatase activity based on excimer-to-monomer transitions, called ExciTide. The nucleotides were designed with two self-interacting dye moieties and synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f0c914bca334f2a32063e2d0e7035f
https://doi.org/10.1039/c8cc04968h
https://doi.org/10.1039/c8cc04968h
Publikováno v:
Molecules, Vol 24, Iss 10, p 1899 (2019)
Molecules
Volume 24
Issue 10
Molecules
Volume 24
Issue 10
The mRNA 5&prime
cap consists of N7-methylguanosine bound by a 5&prime
5&prime
triphosphate bridge to the first nucleotide of the transcript. The cap interacts with various specific proteins and participates in all key mRNA-related pro
cap consists of N7-methylguanosine bound by a 5&prime
5&prime
triphosphate bridge to the first nucleotide of the transcript. The cap interacts with various specific proteins and participates in all key mRNA-related pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebc664ee488b7512a3a26a118bd03a2
https://www.mdpi.com/1420-3049/24/10/1899
https://www.mdpi.com/1420-3049/24/10/1899
Autor:
Joanna Kowalska, Jacek Jemielity, Pawel J. Sikorski, Sebastian Golojuch, Renata Kasprzyk, Michal Kopcial, Natalia Baran, Dominika Strzelecka
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115523
Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed in many cancers deregulating translational control of the cell cycle. mRNA 5’ cap analogs targeting eIF4E are small molecules with the potential to counteract elevated levels of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddba02ade6176ccb34897df2207db062
https://doi.org/10.1016/j.bmc.2020.115523
https://doi.org/10.1016/j.bmc.2020.115523