Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Michal Janitz"'
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16266 (2011)
Recent studies strongly indicate that aberrations in the control of gene expression might contribute to the initiation and progression of Alzheimer's disease (AD). In particular, alternative splicing has been suggested to play a role in spontaneous c
Externí odkaz:
https://doaj.org/article/74e71787791a44eea75014f5219ba1b2
Publikováno v:
Cellular and Molecular Neurobiology. 32:477-489
The clinical manifestations of Alzheimer's disease (AD) are secondary to the substantial loss of cortical neurons. To be effective, neuroprotective strategies will need to target the primary pathogenic mechanisms of AD prior to cell loss. The differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6817b2d1c9c98537d615bd580723847
https://doi.org/10.1007/s10571-012-9797-3
https://doi.org/10.1007/s10571-012-9797-3
Autor:
Dominique Vanhecke, Hans Lehrach, Andrew L. Hufton, Wilfried Nietfeld, Martin Vingron, Michal Janitz, Anna Guerasimova, Thomas Manke, Stefan A. Haas, Robert Querfurth, Marie-Laure Yaspo, Xi Cheng, Hans-Jörg Warnatz
Publikováno v:
Nucleic Acids Research
Given the inherent limitations of in silico studies relying solely on DNA sequence analysis, the functional characterization of mammalian promoters and associated cis-regulatory elements requires experimental support, which demands cloning and analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a2daaebbaa473fbaa896ce6f6b8302
http://europepmc.org/articles/PMC2952857
http://europepmc.org/articles/PMC2952857
Autor:
Michal Janitz, Thomas Manke, Stefan A. Haas, Robert Querfurth, Xi Cheng, Marie-Laure Yaspo, Wilfried Nietfeld, Dominique Vanhecke, Philip Rosenstiel, Hans-Joerg Warnatz, Anna Guerasimova, Hans Lehrach
Publikováno v:
Gene
Promoters are the best characterized transcriptional regulatory sequences in complex genomes because of their predictable location immediately upstream of transcription start sites. Despite a substantial body of literature describing transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f9a918d5b0b200e358e0f4e0158d31
https://doi.org/10.1016/j.gene.2009.10.003
https://doi.org/10.1016/j.gene.2009.10.003
Publikováno v:
Journal of Molecular Histology
Journal of Molecular Histology 40 (5-6): 343-352.
Journal of Molecular Histology 40 (5-6): 343-352.
The subcellular localization of a protein can provide important information about its function within the cell. As eukaryotic cells and particularly mammalian cells are characterized by a high degree of compartmentalization, most protein activities c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a112b34817aba6f817b8d60e9cc4ff
http://europepmc.org/articles/PMC2834777
http://europepmc.org/articles/PMC2834777
Publikováno v:
Molecular Biology Reports
The functional analysis of chromosome 21 (Chr21) proteins is of great medical relevance. This refers, in particular, to the trisomy of human Chr21, which results in Down's syndrome, a complex developmental and neurodegenerative disease. In a previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bf00f86727f0d0d754e46e9beda50f
https://doi.org/10.1007/s11033-009-9926-3
https://doi.org/10.1007/s11033-009-9926-3
Autor:
Alexander Scheffold, Thomas Häupl, Ahmed N. Hegazy, Orhan Aktas, J. Sieper, Michal Janitz, Stephan Kreher, Philipp Enghard, Sina Bartfeld, Cornelia Doebis, Alf Hamann, Juliana Koeck, Inna Gitelman, Marko Janke, Katharina Eulenburg, Gerd R Burmester, Martin Zeitz, Ria Baumgrass, Frauke Zipp, Thomas Kamradt, Rainer Duchmann, Joachim Gruen, Jens Y Humrich, Ulf Schulze-Topphoff, Martin Rudwaleit, Veit Krenn, Daniel C. Baumgart, Kerstin Bonhagen, Christoph Loddenkemper, Uwe Niesner, Max Löhning, Maria H. Lexberg, Bertram Wiedenmann, Inka Albrecht, Hyun D. Chang, Helena Radbruch, Andreas Radbruch, Sascha Rutz
Publikováno v:
The Journal of Experimental Medicine
The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor kappaB (NF-kappaB)-dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology. We show that twist1 is expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643918547059488ea1c9f5b3f2630ad5
http://europepmc.org/articles/PMC2525589
http://europepmc.org/articles/PMC2525589
Publikováno v:
Immunogenetics. 48:266-272
In all vertebrates the major histocompatibility complex (MHC) class II genes are polymorphic in their coding regions as well as in their promoter control elements. This polymorphism correlates with a variability in peptide binding and a variability i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dbff20ee611305d6552fcb3995e790
https://doi.org/10.1007/s002510050431
https://doi.org/10.1007/s002510050431
Publikováno v:
Immunology Letters. 48:139-143
We have investigated mRNA expression for IL-1 alpha and IL-1 beta gene on fractionated human testicular cells. Using RT-PCR and Northern blot hybridization technique we detected the presence of IL-1 alpha transcripts, predominantly in the intratubula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d327ad2a02d8ee0645132b34b90c0c
https://doi.org/10.1016/0165-2478(95)02458-1
https://doi.org/10.1016/0165-2478(95)02458-1
Autor:
Michal Janitz
Written by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, i
