Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michal Hirsch"'
Autor:
Katerina Shulman, Ilana Weiss, Matitiahu Berkovitch, Shai Ashkenazi, Moshe E Gatt, Osnat Luxenburg, Stephany Hiayev, Einat Shacham-Shmueli, Michal Hirsch Vexberg, Rami Hershkowitz, Einat Gorelik, Haim Mayan, Yehudit Steinmetz, Noa Berar Yanai, Orly Schlissel, Muhammad Azem, Neriya Gutgold, Milly Divinsky, Nirit Yarom, Alla Vishkautzan, Chezi Ganzel, Lidia Arcavi, Eli Marom, Biatrice Uziely, Shoshana Zevin, Hadar Meirow, Denize Ainbinder
Publikováno v:
BMJ Open, Vol 13, Iss 5 (2023)
Objectives US FDA and EMA allow facilitated regulatory pathways to expedite access to new treatments. Limited supportive data may result in major postapproval variations. In Israel, partly relying on Food and Drug Administration (FDA) and European Me
Externí odkaz:
https://doaj.org/article/5182d1f30202403fba42ed308f75acff
Akademický článek
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Autor:
Stephany Hiayev, Einat Shacham-Shmueli, Matitiahu Berkovitch, Ilana Weiss, Shai Ashkenazi, Michal Hirsch Vexberg, Rami Hershkowitz, Einat Gorelik, Haim Mayan, Yehudit Steinmetz, Noa Berar Yanai, Orly Schlissel, Muhammad Azem, Neriya Gutgold, Katerina Shulman, Milly Divinsky, Nirit Yarom, Alla Vishkautzan, Chezi Ganzel, Moshe E Gatt, Lidia Arcavi, Eli Marom, Biatrice Uziely, Shoshana Zevin, Hadar Meirow, Osnat Luxenburg, Denize Ainbinder
Publikováno v:
BMJ Open. 13:e067313
ObjectivesUS FDA and EMA allow facilitated regulatory pathways to expedite access to new treatments. Limited supportive data may result in major postapproval variations. In Israel, partly relying on Food and Drug Administration (FDA) and European Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b3cb3a6968b11d5f73e64f6d200cb1f
https://doi.org/10.1136/bmjopen-2022-067313
https://doi.org/10.1136/bmjopen-2022-067313
Publikováno v:
Diabetes. 67
Background: Dapagliflozin is a potential for combination therapy with metformin in T2DM. However, its cost-effectiveness relative to other alternatives in the Israeli healthcare setup remains unknown. Objective: To evaluate the cost-effectiveness of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b8657f9f34ec5a6a0a5bedaffd5645
https://doi.org/10.2337/db18-1297-p
https://doi.org/10.2337/db18-1297-p
Autor:
Michael Shokhen, Netaly Khazanov, Rachel Ozeri, Nurit Perlman, Tamar Traube, Michal Hirsch, Amnon Albeck, S. Vijayakumar
Publikováno v:
Israel Journal of Chemistry. 54:1137-1151
Mechanistic studies of catalysis and the inhibition of serine and cysteine proteases afford new and sometimes surprising insights, challenging conventional dogmas in enzymology. The intrinsic source of the difference in the catalytic mechanisms of se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::046927094636308d1e9b255ed2cc94b0
https://doi.org/10.1002/ijch.201300144
https://doi.org/10.1002/ijch.201300144
Publikováno v:
Journal of Chemical Information and Modeling. 50:2256-2265
We introduce an enzyme mechanism-based method, EMBM, aimed at rational design of chemical sites, CS, of reaction coordinate analog inhibitors. The energy of valence reorganization of CS, caused by the formation of the enzyme-inhibitor covalent comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160da4033b2da8a838b5263a88370f8e
https://doi.org/10.1021/ci100330y
https://doi.org/10.1021/ci100330y
In the first catalytic step in serine proteases, the attacking Ser nucleophile forms an unstable covalent anionic tetrahedral complex, TC(O-), with the carbonyl group of the substrate (Fig. 1a).[1] In the case of reaction coordinate analog inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfed83a477e1ef51622a64d38027ed6
https://europepmc.org/articles/PMC3088911/
https://europepmc.org/articles/PMC3088911/
Autor:
Tamar Traube, Subramaniam Vijayakumar, Michal Hirsch, Neta Uritsky, Michael Shokhen, Amnon Albeck
Publikováno v:
Journal of Chemical Information & Modeling; Dec2010, Vol. 50 Issue 12, p2256-2265, 10p
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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