Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Michal Buša"'
1
Akademický článek
Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes
Autor: Jakub Benýšek, Michal Buša, Petra Rubešová, Jindřich Fanfrlík, Martin Lepšík, Jiří Brynda, Zuzana Matoušková, Ulrike Bartz, Martin Horn, Michael Gütschow, Michael Mareš
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 515-526 (2022)
Cathepsin K (CatK) is a target for the treatment of osteoporosis, arthritis, and bone metastasis. Peptidomimetics with a cyanohydrazide warhead represent a new class of highly potent CatK inhibitors; however, their binding mechanism is unknown. We in
Externí odkaz: https://doaj.org/article/c51df7b09c7a427fa4eefb8b01b73746
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2
Akademický článek
PLANNING AND ECONOMIC PERSPECTIVE OF MATERIAL FLOW
Autor: Michal Buša, Ivana Kazimírová, Martin Paška, Eduard Puškáš, Csaba Farkas
Publikováno v: Acta Logistica, Vol 5, Iss 1, Pp 25-29 (2018)
The production is usually divided into quite a number of handling, control and technological operations in the production enterprise, and these are realized at different workplaces. Parts, semi-finished goods, raw materials and products need to be re
Externí odkaz: https://doaj.org/article/ba5b4b058abd43b8a2bd2ce0dbbfd4cb
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3
An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity
Autor: Lenka Ulrychová, Martin Horn, Carina Lemke, Michal Buša, Michael Gütschow, Dominik Brajtenbach, Jakub Benýšek, Christian Breuer, Katharina F. Kubatzky, Annika Illies, Adéla Jílková, Ulrike Bartz, Michael Mareš
Publikováno v: Journal of Medicinal Chemistry. 64:13793-13806
The cysteine protease cathepsin K is a target for the treatment of diseases associated with high bone turnover. Cathepsin K is mainly expressed in osteoclasts and responsible for the destruction of the proteinaceous components of the bone matrix. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec972a79fa3c0ad74112d81cec9c59be
https://doi.org/10.1021/acs.jmedchem.1c01178
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5
The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin
Autor: Edgar Schmitt, Natascha Stergiou, Helena Langhansová, Eric Calvo, Michail Kotsyfakis, Alexandra Schwarz, Jan Kotál, Michael Mareš, Zuzana Beránková, Jan Kopecký, Pavlína Řezáčová, Adéla Chlastáková, Jindřich Chmelař, Michal Buša
Publikováno v: Cellular and Molecular Life Sciences. 76:2003-2013
To successfully feed, ticks inject pharmacoactive molecules into the vertebrate host including cystatin cysteine protease inhibitors. However, the molecular and cellular events modulated by tick saliva remain largely unknown. Here, we describe and ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86b33541ef7165df6258ab5640f7cb7
https://doi.org/10.1007/s00018-019-03034-3
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7
Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion
Autor: Jindřich Chmelař, Jan Kotál, Helena Langhansová, Michail Kotsyfakis, Daniel Sojka, Pavlína Řezáčová, Michael Mareš, Michal Buša, Veronika Urbanová
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 5371, p 5371 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 10
The hard tick Ixodes ricinus is a vector of Lyme disease and tick-borne encephalitis. Host blood protein digestion, essential for tick development and reproduction, occurs in tick midgut digestive cells driven by cathepsin proteases. Little is known
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968d3618ee1a68b34304c6113aaa7fb0
https://www.mdpi.com/1422-0067/22/10/5371
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8
Mialostatin, a Novel Midgut Cystatin from
Autor: Jan, Kotál, Michal, Buša, Veronika, Urbanová, Pavlína, Řezáčová, Jindřich, Chmelař, Helena, Langhansová, Daniel, Sojka, Michael, Mareš, Michail, Kotsyfakis
Publikováno v: International Journal of Molecular Sciences
The hard tick Ixodes ricinus is a vector of Lyme disease and tick-borne encephalitis. Host blood protein digestion, essential for tick development and reproduction, occurs in tick midgut digestive cells driven by cathepsin proteases. Little is known
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db7acbba450851018448c79d2e971e88
https://pubmed.ncbi.nlm.nih.gov/34065290
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