Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michal Arbel-Ornath"'
Autor:
Ksenia V. Kastanenka, Stephen N. Gomperts, Shuko Takeda, Steven S. Hou, Brian J. Bacskai, Maria Calvo-Rodriguez, Alexander M. Kim, Amanda J. Lariviere, Xiqun Chen, Robert Logan, Yee Fun Lee, Heng Zhou, Michal Arbel-Ornath, Danielle Feng, Jonathan M. Hawkes
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Neuronal activity patterns are disrupted in neurodegenerative disorders, including Alzheimer’s disease (AD). One example is disruption of corticothalamic slow oscillations responsible for sleep-dependent memory consolidation. Slow waves are periodi
Autor:
Susanne J. van Veluw, Brian J. Bacskai, Austin Snyder, Michal Arbel-Ornath, Steven M. Greenberg, Steven S. Hou, Matthew P. Frosch, Maria Calvo-Rodriguez
Publikováno v:
Neuron
Summary Paravascular drainage of solutes, including β-amyloid (Aβ), appears to be an important process in brain health and diseases such as Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA). However, the major driving force for clear
Autor:
Roy O. Weller, Alan Morris, Michal Arbel-Ornath, Beatrice Bedussi, Brian J. Bacskai, Roxana O. Carare, Erik N. T. P. Bakker, Roxana Aldea
Publikováno v:
Cellular and Molecular Neurobiology
The lymphatic clearance pathways of the brain are different compared to the other organs of the body and have been the subject of heated debates. Drainage of brain extracellular fluids, particularly interstitial fluid (ISF) and cerebrospinal fluid (C
Autor:
Eloise Hudry, Elena Galea, Michal Arbel-Ornath, H. Eugene Stanley, Bradley T. Hyman, Brian J. Bacskai, Will Morrison, Teresa Gomez-Isla
Publikováno v:
Proceedings of the National Academy of Sciences. 112:15556-15561
Significance We sought to identify forces shaping the interaction between astrocytes and amyloid-β plaques by performing a spatial analysis, using tools from statistical physics, of 3D images from living transgenic mice. We discovered that astrocyte
Autor:
Brian J. Bacskai, Matthew P. Frosch, Xueying Wang, Steven M. Greenberg, Rebecca A. Betensky, Michal Arbel-Ornath, Lingzhi Zhao
Publikováno v:
Neurobiology of Aging. 36:2963-2971
Cerebral amyloid angiopathy (CAA), the deposition of amyloid-β in cerebrovascular walls, is the most common cause of lobar hemorrhagic stroke. Previous studies show that cerebrovascular amyloid-β induces expression and activation of matrix metallop
Autor:
Izumi Yuzawa, Arn M. J. M. van den Maagdenberg, Nilufer Yalcin, Andrea J. Arreguin, Brian J. Bacskai, Cenk Ayata, Fatmagul Keles, Katharina Eikermann-Haerter, Isaac A. Rosen, Buse Sengul, Esther S. Yu, Arianna M. Belcher, Mihail Climov, Eloise Hudry, Michel D. Ferrari, Michal Arbel-Ornath, Kishore V. Kuchibhotla, Carli R. Willard, Andrea Negro
Publikováno v:
Annals of Neurology. 78:193-210
Objective Migraine is one of the most common and debilitating neurological conditions. Familial hemiplegic migraine type 1 (FHM1), a monogenic migraine subtype, is caused by gain-of-function of voltage-gated CaV2.1 calcium channels. FHM1 mice carry h
Autor:
Josiah R. Boivin, Steven S. Hou, Bradley T. Hyman, Rebecca A. Betensky, Tadafumi Hashimoto, Naomi Shakerdge, Carli R. Lattarulo, Pariss B. Trujillo, Arianna M. Belcher, Kishore V. Kuchibhotla, Eloise Hudry, Alona Muzikansky, Michal Arbel-Ornath, Shuko Takeda, Brian J. Bacskai
Publikováno v:
Molecular Neurodegeneration
Background Amyloid-β oligomers (oAβ) are thought to mediate neurotoxicity in Alzheimer’s disease (AD), and previous studies in AD transgenic mice suggest that calcium dysregulation may contribute to these pathological effects. Even though AD mous
Autor:
Brian J. Bacskai, Steven S. Hou, Matthew P. Frosch, Lingzhi Zhao, Steven M. Greenberg, Julia L. Gregory, Rebecca A. Betensky, Michal Arbel-Ornath, Katharina Eikermann-Haerter, Eloise Hudry
Publikováno v:
Acta Neuropathologica. 126:353-364
The interstitial fluid (ISF) drainage pathway has been hypothesized to underlie the clearance of solutes and metabolites from the brain. Previous work has implicated the perivascular spaces along arteries as the likely route for ISF clearance; howeve
Autor:
Rebecca A. Betensky, Steven M. Greenberg, Matthew P. Frosch, Julia L. Gregory, Monica Garcia-Alloza, Michal Arbel-Ornath, Sara Fine, Claudia Prada, Brian J. Bacskai
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 71:1009-1017
Cerebral amyloid angiopathy (CAA), the accumulation of β-amyloid (Aβ) in the walls of leptomeningeal and cortical blood vessels of the brain, is a major cause of intracerebral hemorrhage and cognitive impairment and is commonly associated with Alzh
Autor:
Beka Solomon, Polina Rabinovich-Toidman, María Inés Becker, Myra Gartner, Michal Arbel-Ornath
Publikováno v:
Journal of Alzheimer's Disease. 22:469-482
Among the different paradigms aimed at interfering with amyloid-β (Aβ)-related pathology, the attenuation of amyloid-β protein precursor (AβPP) processing to limit Aβ levels seems to be a promising one. Along with the development of BACE1 inhibi