Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Michal A Surma"'
Autor:
Mathias J Gerl, Christian Klose, Michal A Surma, Celine Fernandez, Olle Melander, Satu Männistö, Katja Borodulin, Aki S Havulinna, Veikko Salomaa, Elina Ikonen, Carlo V Cannistraci, Kai Simons
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000443 (2019)
Obesity is associated with changes in the plasma lipids. Although simple lipid quantification is routinely used, plasma lipids are rarely investigated at the level of individual molecules. We aimed at predicting different measures of obesity based on
Externí odkaz:
https://doaj.org/article/d4fde52f73124460874e32b40039a735
Autor:
Janek Salatzki, Anna Foryst-Ludwig, Kajetan Bentele, Annelie Blumrich, Elia Smeir, Zsofia Ban, Sarah Brix, Jana Grune, Niklas Beyhoff, Robert Klopfleisch, Sebastian Dunst, Michal A Surma, Christian Klose, Michael Rothe, Frank R Heinzel, Alexander Krannich, Erin E Kershaw, Dieter Beule, P Christian Schulze, Nikolaus Marx, Ulrich Kintscher
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007171 (2018)
Adipose tissue lipolysis occurs during the development of heart failure as a consequence of chronic adrenergic stimulation. However, the impact of enhanced adipose triacylglycerol hydrolysis mediated by adipose triglyceride lipase (ATGL) on cardiac f
Externí odkaz:
https://doaj.org/article/ad8ab46f3d804bf2a9226a30b7313c13
Autor:
Christian Klose, Michal A Surma, Mathias J Gerl, Felix Meyenhofer, Andrej Shevchenko, Kai Simons
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35063 (2012)
Mass spectrometry-based shotgun lipidomics has enabled the quantitative and comprehensive assessment of cellular lipid compositions. The yeast Saccharomyces cerevisiae has proven to be a particularly valuable experimental system for studying lipid-re
Externí odkaz:
https://doaj.org/article/ed88b3b0e3264d01a5c7f84b3dea3c6d
Autor:
Neuza Domingues, Joana Gaifem, Rune Matthiesen, Diana P. Saraiva, Luís Bento, André R.A. Marques, Maria I.L. Soares, Julio Sampaio, Christian Klose, Michal A. Surma, Manuel S. Almeida, Gustavo Rodrigues, Pedro Araújo Gonçalves, Jorge Ferreira, Ryan Gouveia e Melo, Luís Mendes Pedro, Kai Simons, Teresa M.V.D. Pinho e Melo, M. Guadalupe Cabral, Antonio Jacinto, Ricardo Silvestre, Winchil Vaz, Otília V. Vieira
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 9, Pp 100419- (2023)
Oxidation of PUFAs in LDLs trapped in the arterial intima plays a critical role in atherosclerosis. Though there have been many studies on the atherogenicity of oxidized derivatives of PUFA-esters of cholesterol, the effects of cholesteryl hemiesters
Externí odkaz:
https://doaj.org/article/c30b5b392865415ea5ffdfe2b3bea9a3
Autor:
Joel T. Rämö, Pietari Ripatti, Rubina Tabassum, Sanni Söderlund, Niina Matikainen, Mathias J. Gerl, Christian Klose, Michal A. Surma, Nathan O. Stitziel, Aki S. Havulinna, Matti Pirinen, Veikko Salomaa, Nelson B. Freimer, Matti Jauhiainen, Aarno Palotie, Marja‐Riitta Taskinen, Kai Simons, Samuli Ripatti
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 13 (2019)
Background We asked whether, after excluding familial hypercholesterolemia, individuals with high low‐density lipoprotein cholesterol (LDL‐C) or triacylglyceride levels and a family history of the same hyperlipidemia have greater coronary artery
Externí odkaz:
https://doaj.org/article/cf5345777bec45d59bdb177eb68eeeb9
Autor:
Neuza Domingues, Joana Gaifem, Rune Matthiesen, Diana P. Saraiva, Luís Bento, André R.A. Marques, Maria I. L. Soares, Julio Sampaio, Christian Klose, Michal A. Surma, Manuel S. Almeida, Gustavo Rodrigues, Pedro Araújo Gonçalves, Jorge Ferreira, Ryan Gouveia e Melo, Luís Mendes Pedro, Kai Simons, Teresa M. V. D. Pinho e Melo, M. Guadalupe Cabral, Antonio Jacinto, Ricardo Silvestre, Winchil Vaz, Otília V. Vieira
Oxidation of polyunsaturated fatty acids (PUFA) in low-density lipoproteins (LDL) trapped in the arterial intima plays a critical role in atherosclerosis. Though there have been many studies on the atherogenicity of oxidized derivatives of unsaturate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fed33e6e31e3b082f7491a1e04b301c5
https://doi.org/10.1101/2023.02.09.527823
https://doi.org/10.1101/2023.02.09.527823
Autor:
Sebastian Boland, Sharan Swarup, Yohannes A. Ambaw, Pedro C. Malia, Ruth C. Richards, Alexander W. Fischer, Shubham Singh, Geetika Aggarwal, Salvatore Spina, Alissa L. Nana, Lea T. Grinberg, William W. Seeley, Michal A. Surma, Christian Klose, Joao A. Paulo, Andrew D. Nguyen, J. Wade Harper, Tobias C. Walther, Robert V. Farese
Publikováno v:
Nature communications, vol 13, iss 1
Haploinsufficiency of GRN causes frontotemporal dementia (FTD). The GRN locus produces progranulin (PGRN), which is cleaved to lysosomal granulin polypeptides. The function of lysosomal granulins and why their absence causes neurodegeneration are unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cd2ebc3537e5ee0eb45c826f425379
https://escholarship.org/uc/item/7p7865xx
https://escholarship.org/uc/item/7p7865xx
Autor:
Martina Arends, Melanie Weber, Cyrus Papan, Markus Damm, Michal A. Surma, Christopher Spiegel, Minou Djannatian, Shengrong Li, Lisa Connell, Ludger Johannes, Martina Schifferer, Christian Klose, Mikael Simons
Publikováno v:
iScience 25(11), 105323-(2022). doi:10.1016/j.isci.2022.105323
Gangliosides are present and concentrated in axons and implicated in axon-myelin interactions, but how ganglioside composition changes during myelin formation is not known. Here, we present a direct infusion (shotgun) lipidomics method to analyze gan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561b4d66bb78654e8e48e3ff0f03e625
https://pubmed.ncbi.nlm.nih.gov/36310581
https://pubmed.ncbi.nlm.nih.gov/36310581
Autor:
Sanela Kjellqvist, Christian Klose, Michal A. Surma, George Hindy, Inês G. Mollet, Anna Johansson, Patrick Chavaux, Johan Gottfries, Kai Simons, Olle Melander, Céline Fernandez
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 12 (2016)
BackgroundDiabetes mellitus (DM) and cardiovascular disease are associated with dyslipidemia, but the detailed lipid molecular pattern in both diseases remains unknown. Methods and ResultsWe used shotgun mass spectrometry to determine serum levels of
Externí odkaz:
https://doaj.org/article/6e19ae8b74264bf7b979e481028f9bc0
Autor:
Michal A. Surma, Anne Berit Dyve Lingelem, Simona Kavaliauskiene, Tore Skotland, Christian Klose, Ruth Halsne, Tove Irene Klokk, Kirsten Sandvig
Publikováno v:
Cellular and Molecular Life Sciences
The membrane lipids diacylglycerol (DAG) and phosphatidic acid (PA) are important second messengers that can regulate membrane transport by recruiting proteins to the membrane and by altering biophysical membrane properties. DAG and PA are involved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02713700c22f2e4b68fed1f61a2d35b9
https://doi.org/10.1007/s00018-020-03551-6
https://doi.org/10.1007/s00018-020-03551-6