Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Michal A Surma"'
Autor:
Neuza Domingues, Joana Gaifem, Rune Matthiesen, Diana P. Saraiva, Luís Bento, André R.A. Marques, Maria I.L. Soares, Julio Sampaio, Christian Klose, Michal A. Surma, Manuel S. Almeida, Gustavo Rodrigues, Pedro Araújo Gonçalves, Jorge Ferreira, Ryan Gouveia e Melo, Luís Mendes Pedro, Kai Simons, Teresa M.V.D. Pinho e Melo, M. Guadalupe Cabral, Antonio Jacinto, Ricardo Silvestre, Winchil Vaz, Otília V. Vieira
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 9, Pp 100419- (2023)
Oxidation of PUFAs in LDLs trapped in the arterial intima plays a critical role in atherosclerosis. Though there have been many studies on the atherogenicity of oxidized derivatives of PUFA-esters of cholesterol, the effects of cholesteryl hemiesters
Externí odkaz:
https://doaj.org/article/c30b5b392865415ea5ffdfe2b3bea9a3
Autor:
Sebastian Boland, Sharan Swarup, Yohannes A. Ambaw, Pedro C. Malia, Ruth C. Richards, Alexander W. Fischer, Shubham Singh, Geetika Aggarwal, Salvatore Spina, Alissa L. Nana, Lea T. Grinberg, William W. Seeley, Michal A. Surma, Christian Klose, Joao A. Paulo, Andrew D. Nguyen, J. Wade Harper, Tobias C. Walther, Robert V. Farese
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.
Externí odkaz:
https://doaj.org/article/1474593e97d94a4ab73bc2bde059f30e
Autor:
Martina Arends, Melanie Weber, Cyrus Papan, Markus Damm, Michal A. Surma, Christopher Spiegel, Minou Djannatian, Shengrong Li, Lisa Connell, Ludger Johannes, Martina Schifferer, Christian Klose, Mikael Simons
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105323- (2022)
Summary: Gangliosides are present and concentrated in axons and implicated in axon-myelin interactions, but how ganglioside composition changes during myelin formation is not known. Here, we present a direct infusion (shotgun) lipidomics method to an
Externí odkaz:
https://doaj.org/article/dac704c314c64c368965ca0de5ef3011
Autor:
Rubina Tabassum, Joel T. Rämö, Pietari Ripatti, Jukka T. Koskela, Mitja Kurki, Juha Karjalainen, Priit Palta, Shabbeer Hassan, Javier Nunez-Fontarnau, Tuomo T. J. Kiiskinen, Sanni Söderlund, Niina Matikainen, Mathias J. Gerl, Michal A. Surma, Christian Klose, Nathan O. Stitziel, Hannele Laivuori, Aki S. Havulinna, Susan K. Service, Veikko Salomaa, Matti Pirinen, FinnGen Project, Matti Jauhiainen, Mark J. Daly, Nelson B. Freimer, Aarno Palotie, Marja-Riitta Taskinen, Kai Simons, Samuli Ripatti
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cardiovascular diseases (CVD) are associated with plasma lipid levels. Here, Tabassum et al. perform genome-wide association studies for lipidomic profiles with 141 (non-standard) lipid species which highlights shared genetic loci with CVD and that t
Externí odkaz:
https://doaj.org/article/a7b6a56d3eec433f97120fae91d896c5
Autor:
Michal Grzybek, Alessandra Palladini, Vasileia I. Alexaki, Michal A. Surma, Kai Simons, Triantafyllos Chavakis, Christian Klose, Ünal Coskun
Publikováno v:
Molecular Metabolism, Vol 22, Iss , Pp 12-20 (2019)
Objective: Shotgun lipidomics enables an extensive analysis of lipids from tissues and fluids. Each specimen requires appropriate extraction and processing procedures to ensure good coverage and reproducible quantification of the lipidome. Adipose ti
Externí odkaz:
https://doaj.org/article/e95cc001e0cc4e5d95b45e0b3f55f6bb
Autor:
Grzegorz Chwastek, Michal A. Surma, Sandra Rizk, Daniel Grosser, Oksana Lavrynenko, Magdalena Rucińska, Helena Jambor, James Sáenz
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108165- (2020)
Summary: Cells, from microbes to mammals, adapt their membrane lipid composition in response to environmental changes to maintain optimal properties. Global patterns of lipidome remodeling are poorly understood, particularly in organisms with simple
Externí odkaz:
https://doaj.org/article/0f1ec137fa0a47098fba5ec8ffddb057
Autor:
John Reinhard, Carsten Mattes, Kristina Väth, Toni Radanović, Michal A. Surma, Christian Klose, Robert Ernst
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The unfolded protein response (UPR) is central to endoplasmic reticulum (ER) homeostasis by controlling its size and protein folding capacity. When activated by unfolded proteins in the ER-lumen or aberrant lipid compositions, the UPR adjusts the exp
Externí odkaz:
https://doaj.org/article/4232516a42df4382b87dadb19ed54dc9
Autor:
John A. Bowden, Alan Heckert, Candice Z. Ulmer, Christina M. Jones, Jeremy P. Koelmel, Laila Abdullah, Linda Ahonen, Yazen Alnouti, Aaron M. Armando, John M. Asara, Takeshi Bamba, John R. Barr, Jonas Bergquist, Christoph H. Borchers, Joost Brandsma, Susanne B. Breitkopf, Tomas Cajka, Amaury Cazenave-Gassiot, Antonio Checa, Michelle A. Cinel, Romain A. Colas, Serge Cremers, Edward A. Dennis, James E. Evans, Alexander Fauland, Oliver Fiehn, Michael S. Gardner, Timothy J. Garrett, Katherine H. Gotlinger, Jun Han, Yingying Huang, Aveline Huipeng Neo, Tuulia Hyötyläinen, Yoshihiro Izumi, Hongfeng Jiang, Houli Jiang, Jiang Jiang, Maureen Kachman, Reiko Kiyonami, Kristaps Klavins, Christian Klose, Harald C. Köfeler, Johan Kolmert, Therese Koal, Grielof Koster, Zsuzsanna Kuklenyik, Irwin J. Kurland, Michael Leadley, Karen Lin, Krishna Rao Maddipati, Danielle McDougall, Peter J. Meikle, Natalie A. Mellett, Cian Monnin, M. Arthur Moseley, Renu Nandakumar, Matej Oresic, Rainey Patterson, David Peake, Jason S. Pierce, Martin Post, Anthony D. Postle, Rebecca Pugh, Yunping Qiu, Oswald Quehenberger, Parsram Ramrup, Jon Rees, Barbara Rembiesa, Denis Reynaud, Mary R. Roth, Susanne Sales, Kai Schuhmann, Michal Laniado Schwartzman, Charles N. Serhan, Andrej Shevchenko, Stephen E. Somerville, Lisa St. John-Williams, Michal A. Surma, Hiroaki Takeda, Rhishikesh Thakare, J. Will Thompson, Federico Torta, Alexander Triebl, Martin Trötzmüller, S. J. Kumari Ubhayasekera, Dajana Vuckovic, Jacquelyn M. Weir, Ruth Welti, Markus R. Wenk, Craig E. Wheelock, Libin Yao, Min Yuan, Xueqing Heather Zhao, Senlin Zhou
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 12, Pp 2275-2288 (2017)
As the lipidomics field continues to advance, self-evaluation within the community is critical. Here, we performed an interlaboratory comparison exercise for lipidomics using Standard Reference Material (SRM) 1950–Metabolites in Frozen Human Plasma
Externí odkaz:
https://doaj.org/article/e757670a32e84af9bc9bad52c975b5dc
Autor:
Turid Frahnow, Martin A. Osterhoff, Silke Hornemann, Michael Kruse, Michal A. Surma, Christian Klose, Kai Simons, Andreas F. H. Pfeiffer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Lipidomics have a great potential as clinical tool for monitoring metabolic changes in health and disease. Nevertheless hardly anything is known about the heritability of lipids. Therefore, it is necessary to clarify how and how much we can
Externí odkaz:
https://doaj.org/article/0457bd64ab80427fad165d8dfe28746c
Autor:
Mathias J Gerl, Christian Klose, Michal A Surma, Celine Fernandez, Olle Melander, Satu Männistö, Katja Borodulin, Aki S Havulinna, Veikko Salomaa, Elina Ikonen, Carlo V Cannistraci, Kai Simons
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000443 (2019)
Obesity is associated with changes in the plasma lipids. Although simple lipid quantification is routinely used, plasma lipids are rarely investigated at the level of individual molecules. We aimed at predicting different measures of obesity based on
Externí odkaz:
https://doaj.org/article/d4fde52f73124460874e32b40039a735