Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michal, Zielinski"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Farnesyl pyrophosphate (FPP) is a key building block for the synthesis of many lipids. Here the authors determine the crystal structure of farnesyl pyrophosphate synthase (FPPS) with its bound product and use kinetic measurements to show that FPP is
Externí odkaz:
https://doaj.org/article/111b9b63900a4b0cbd2922f6e1276728
Autor:
Rafal Kukawka, Anna Pawlowska-Zygarowicz, Rafal Januszewski, Joanna Dzialkowska, Mariusz Pietrowski, Michal Zielinski, Hieronim Maciejewski, Marcin Smiglak
Publikováno v:
Catalysts, Vol 10, Iss 12, p 1414 (2020)
Functionalized siloxanes are one of the most important classes of organosilicon compounds, thus the enhancement of current methods of its synthesis is an important issue. Herein, we present the selective and highly effective reaction between 1,1,3,3-
Externí odkaz:
https://doaj.org/article/37a596ff156b45a197b604d394468868
Autor:
Ellen Clancy, John M. Jumper, Simon A. A. Kohl, Pushmeet Kohli, Andrew Cowie, Andrew J. Ballard, David Reiman, Gerard J. Kleywegt, Agata Laydon, Ewan Birney, Alexander Pritzel, Clemens Meyer, Michal Zielinski, Alex Bridgland, Stig Petersen, Jonas Adler, Tim Green, Michael Figurnov, Alex Bateman, Russell Bates, Zachary Wu, Andrew W. Senior, Stanislav Nikolov, Demis Hassabis, Koray Kavukcuoglu, Sameer Velankar, Bernardino Romera-Paredes, Augustin Žídek, Kathryn Tunyasuvunakool, R. D. Jain, Olaf Ronneberger, Richard Evans, Anna Potapenko
Publikováno v:
Nature
Protein structures can provide invaluable information, both for reasoning about biological processes and for enabling interventions such as structure-based drug development or targeted mutagenesis. After decades of effort, 17% of the total residues i
Autor:
Ivan Protsyuk, Martin G. Seneviratne, Andre Saraiva, Natalie Harris, Hugh Montgomery, Mustafa Suleyman, Xavier Glorot, Dominic King, Jack W. Rae, Clifton R. Baker, Alistair Connell, Suman V. Ravuri, Trevor Back, Clemens Meyer, Nenad Tomasev, Harry Askham, Michal Zielinski, Ruth M. Reeves, Joseph R. Ledsam, Shakir Mohamed, Thomas F. Osborne, Cian Hughes, Chris Laing, Alan Karthikesalingam, Valerio Magliulo, Anne Mottram, Christopher Nielson, Sebastien Baur, Julien Cornebise, Demis Hassabis, Geraint Rees
Publikováno v:
Nature Protocols. 16:2765-2787
Early prediction of patient outcomes is important for targeting preventive care. This protocol describes a practical workflow for developing deep-learning risk models that can predict various clinical and operational outcomes from structured electron
Autor:
Ilona Karpiel, Jakub Woloszyn, Kamil Olesz, Maciej Mysinski, Mirella Urzeniczok, Michal Zielinski, Sebastian Glowacki, Daniel Feige, Aleksander Sobotnicki, Marek Czerw
Publikováno v:
2022 29th International Conference on Mixed Design of Integrated Circuits and System (MIXDES).
Autor:
Pawel Wieczorek, Maciej Maslanka, Marek Malysz, Wojciech Wieczorek, Michal Zielinski, Marta Grycan, Lars Konge, Lukasz Szarpak
Publikováno v:
TRC Journal of Medicine. 1
Aim: This study was designed with the aim of evaluating Vie Scope®’s role in placing an endotracheal tube (ETT) by paramedics wearing full personal protective equipment who are experienced in direct laryngoscopy but inexperienced in using the Vie
Autor:
Sam Blackwell, Andrew W. Senior, Pushmeet Kohli, Andrew Cowie, Kathryn Tunyasuvunakool, Michal Zielinski, John M. Jumper, Anna Potapenko, Russell Bates, Augustin Žídek, Tim Green, R. D. Jain, Olaf Ronneberger, Sebastian Bodenstein, Richard Evans, Michael J. O'Neill, Ellen Clancy, Jason Yim, Alexander Pritzel, Natasha Antropova, Demis Hassabis, Alex Bridgland
While the vast majority of well-structured single protein chains can now be predicted to high accuracy due to the recent AlphaFold [1] model, the prediction of multi-chain protein complexes remains a challenge in many cases. In this work, we demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::173d0a046880041a9ef0fe19e68506d0
https://doi.org/10.1101/2021.10.04.463034
https://doi.org/10.1101/2021.10.04.463034
Autor:
Tamas Berghammer, Martin Steinegger, Anna Potapenko, R. D. Jain, Olaf Ronneberger, John M. Jumper, Russell Bates, David Silver, Simon A. A. Kohl, Tim Green, Michael Figurnov, Andrew J. Ballard, Oriol Vinyals, Michal Zielinski, Stig Petersen, Jonas Adler, Alex Bridgland, Trevor Back, Alexander Pritzel, Michalina Pacholska, Ellen Clancy, Koray Kavukcuoglu, Kathryn Tunyasuvunakool, Stanislav Nikolov, Andrew W. Senior, Demis Hassabis, Clemens Meyer, Richard Evans, David Reiman, Augustin Žídek, Andrew Cowie, Pushmeet Kohli, Bernardino Romera-Paredes
Publikováno v:
Proteins. 89(12)
We describe the operation and improvement of AlphaFold* , the system that was entered by the team AlphaFold2 to the "human" category in the 14th Critical Assessment of Protein Structure Prediction (CASP14). The AlphaFold system entered in CASP14 is e
Autor:
null John Jumper, null Richard Evans, null Alexander Pritzel, null Tim Green, null Michael Figurnov, null Olaf Ronneberger, null Kathryn Tunyasuvunakool, null Russ Bates, null Augustin Žídek, null Anna Potapenko, null Alex Bridgland, null Clemens Meyer, null Simon A. A. Kohl, null Andrew J. Ballard, null Andrew Cowie, null Bernardino Romera‐Paredes, null Stanislav Nikolov, null Rishub Jain, null Jonas Adler, null Trevor Back, null Stig Petersen, null David Reiman, null Ellen Clancy, null Michal Zielinski, null Martin Steinegger, null Michalina Pacholska, null Tamas Berghammer, null David Silver, null Oriol Vinyals, null Andrew W. Senior, null Koray Kavukcuoglu, null Pushmeet Kohli, null Demis Hassabis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47b8bd5303b88aa1248b496ff3f8336c
https://doi.org/10.1002/prot.26257/v2/response1
https://doi.org/10.1002/prot.26257/v2/response1
Autor:
John M. Jumper, Pushmeet Kohli, Andrew J. Ballard, Kathryn Tunyasuvunakool, Bernardino Romera-Paredes, Simon A. A. Kohl, Andrew W. Senior, Alexander Pritzel, Sebastian Bodenstein, Ellen Clancy, Michalina Pacholska, Trevor Back, Clemens Meyer, Stanislav Nikolov, Richard O. Evans, Oriol Vinyals, Alex Bridgland, Demis Hassabis, Tamas Berghammer, Michal Zielinski, Stig Petersen, Jonas Adler, Michael Figurnov, Anna Potapenko, Andrew Cowie, David Reiman, Augustin Žídek, Tim Green, Russell Bates, David L. Silver, Koray Kavukcuoglu, R. D. Jain, Olaf Ronneberger, Martin Steinegger
Publikováno v:
Nature
Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1–4, the structures of around 100,000 unique proteins have been determined5, but