Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michal, Lederman"'
Autor:
Michal Lederman, Shira Hagbi-Levi, Michelle Grunin, Alexey Obolensky, Eduard Berenshtein, Eyal Banin, Mordechai Chevion, Itay Chowers
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87751 (2014)
Oxidative injury is involved in retinal and macular degeneration. We aim to assess if retinal degeneration associated with genetic defect modulates the retinal threshold for encountering additional oxidative challenges.Retinal oxidative injury was in
Externí odkaz:
https://doaj.org/article/34264103996e4f829ff4402d9ae43170
Zinc–desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa
Autor:
Eyal Banin, Michal Lederman, Eduard Berenshtein, Itay Chowers, Mordechai Chevion, Ruslana Alper-Pinus, Ruth Yaul, Efrat Deleon, Alexey Obolensky, Baruch Bulvik
Publikováno v:
Free Radical Biology and Medicine. 51:1482-1491
Iron-associated oxidative injury plays a role in retinal degeneration such as age-related macular degeneration and retinitis pigmentosa. The metallo-complex zinc-desferrioxamine (Zn/DFO) may ameliorate such injury by chelation of labile iron in combi
Publikováno v:
Current Eye Research. 33:876-884
Members of the inhibitors of apoptosis proteins (IAPs) family are thought to promote tumor growth and interfere with response to therapy by suppressing apoptosis in several malignancies. We aimed to evaluate the expression of IAPs in uveal melanoma (
Autor:
Itay Chowers, Shira Hagbi-Levi, Eduard Berenshtein, Michal Lederman, Eyal Banin, Mordechai Chevion, Michelle Grunin, Alexey Obolensky
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e87751 (2014)
PLoS ONE, Vol 9, Iss 2, p e87751 (2014)
Purpose Oxidative injury is involved in retinal and macular degeneration. We aim to assess if retinal degeneration associated with genetic defect modulates the retinal threshold for encountering additional oxidative challenges. Methods Retinal oxidat
Publikováno v:
Investigative ophthalmologyvisual science. 51(4)
Purpose. To examine the involvement of nuclear factor-kappa B (NFkappaB) pathways in uveal melanoma (UM) and to assess their potential as a therapeutic target for metastatic UM. Methods. Samples from primary (n = 7) and metastatic (n = 7) UM were eva
Autor:
Tal Meir, Michal Lederman, Smadar Horowitz, Itay Chowers, Saleh Abu Asleh, Shoshana Israel, Amnon Lahad, Dror Sharon, Orly Weinstein, Nurit Goldstein
Publikováno v:
Ophthalmic genetics. 30(4)
Background: Altered iron metabolism and transferrin expression were associated with neurodegenerations including age-related macular degeneration (AMD) and Alzheimer’s disease (AD). Carriers of transferrin C2 allele alone or in combination with the
Publikováno v:
Investigative ophthalmologyvisual science. 51(1)
Purpose Inflammation probably plays a major role in the pathogenesis of age-related macular degeneration (AMD). The authors evaluated whether AMD is associated with gene expression patterns in white blood cells (WBCs) and whether such a pattern may s
Publikováno v:
Investigative ophthalmologyvisual science. 50(3)
PURPOSE. Altered iron metabolism was implicated in retinal and macular degeneration. This study was designed to further elucidate iron homeostasis during the course of retinal degeneration in mice. METHODS. Retinal mRNA and protein expression of tran
Autor:
Itay, Chowers, Tal, Meir, Michal, Lederman, Nitza, Goldenberg-Cohen, Yoram, Cohen, Eyal, Banin, Edward, Averbukh, Itzhak, Hemo, Ayala, Pollack, Ruth, Axer-Siegel, Orly, Weinstein, Josephine, Hoh, Donald J, Zack, Tural, Galbinur
Publikováno v:
Molecular Vision
Purpose Single nucleotide polymorphisms (SNPs) in the tightly linked LOC387715/ARMS2 and HTRA1 genes have been associated with age-related macular degeneration (AMD). We tested whether these SNPs are associated with AMD in Israeli populations, if the
Publikováno v:
Investigative Opthalmology & Visual Science. 53:605
PURPOSE The iron carrier transferrin is expressed at remarkably high levels in normal retinas and is upregulated during retinal degeneration. The authors characterized the consequences of genetically reduced retinal transferrin production on retinal