Digital health technology to support patient-centered shared decision making at point of care for juvenile idiopathic arthritis

Autor: Bin Huang, Michal Kouril, Chen Chen, Nancy M. Daraiseh, Kerry Ferraro, Melissa L. Mannion, Hermine I. Brunner, Daniel J. Lovell, Esi M. Morgan

Publikováno v: Frontiers in Pediatrics, Vol 12 (2024)

Despite availability of multiple FDA approved therapies, many children with juvenile idiopathic arthritis (JIA) suffer pain and disability due to uncontrolled disease. The term JIA includes a heterogeneous set of conditions unified by chronic inflamm

Externí odkaz: https://doaj.org/article/f678531c911944d0be55b880e6d38298

An application programming interface implementing Bayesian approaches for evaluating effect of time-varying treatment with R and Python

Autor: Chen Chen, Bin Huang, Michal Kouril, Jinzhong Liu, Hang Kim, Siva Sivaganisan, Jeffrey A. Welge, Melissa P. DelBello

Publikováno v: Frontiers in Computer Science, Vol 5 (2023)

IntroductionMethods and tools evaluating treatment effect have been primarily developed for binary type of treatment. Yet, treatment is rarely binary outside the experimental setting, varies by dosage, frequency and time. Treatment is routinely adjus

Externí odkaz: https://doaj.org/article/150523cee15943ddb46478a8748eb300

GRcalculator: an online tool for calculating and mining dose–response data

Autor: Nicholas A. Clark, Marc Hafner, Michal Kouril, Elizabeth H. Williams, Jeremy L. Muhlich, Marcin Pilarczyk, Mario Niepel, Peter K. Sorger, Mario Medvedovic

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)

Abstract Background Quantifying the response of cell lines to drugs or other perturbagens is the cornerstone of pre-clinical drug development and pharmacogenomics as well as a means to study factors that contribute to sensitivity and resistance. In d

Externí odkaz: https://doaj.org/article/4357f58f6bbf40c38dbaa4f40d80a26b

An observational study of Internet behaviours for adolescent females following sexual abuse

Autor: Mojtaba Kohram, Jennie G. Noll, Jaclyn E. Barnes, Matteo Malgaroli, Michelle F. Wright, Michal Kouril, David Foley, Chad E. Shenk, Ann Christin Haag, George A. Bonanno

Publikováno v: Nat Hum Behav

Child sexual abuse (CSA) is associated with revictimization and sexual risk-taking behaviours. The Internet has increased the opportunities for teens to access sexually explicit imagery and has provided new avenues for victimization and exploitation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d80f54c9be859a7ca7ed402dee29c7
https://doi.org/10.1038/s41562-021-01187-5

The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system

Autor: Batsal Devkota, Michal Kouril, Joseph W. St. Geme, Alba Gutierrez, Simone Temporal, Keith Marsolo, Peter White, Joseph A. Majzoub, Alan Yen, Jaspreet Khanna, Julie Wijesooriya, Mike Furgason, Florence T. Bourgeois, Christopher Geehan, Adda Grimberg, Arnold W. Strauss, Becca Harper, Kristen Safier, Aleksandr Nikitin, Andrew Wooten, Vidhu V Thaker, Deanne Taylor, Ingo Helbig, Darlene Barkman, Anil Kumar Degala, Gelvina Stevenson, Eric D. Marsh, Colin P. Hawkes, Andrew Dauber, Jason Stedman, In-Hee Lee, Andrew M. Rupert, Gary R. Fleisher, Ramkrishna Chakrabarty, Piotr Sliz, Alyssa Ellis, Barbara Hallinan, Kenneth D. Mandl, Susan Kornetsky, Bryan A. Wolf, Philip Dexheimer, Alan H. Beggs, Yu Zhang, Erin M. Borglund, Joel N. Hirschhorn, Andrew Joseph Guidetti, Amy Schwarzhoff, Anna Poduri, Gabor Korodi, Louis J. Muglia, Prakash Velayutham, Christopher P. Kirby, Mike Pistone, Allison Heath, Parth Divekar, Judson Kilbourn, Ranjay Kumar, Guillaume Labilloy, Alka Chandel, Ian D. Krantz, Thomas N DeSain, Kristen L. Sund, Lisa J. Martin, James Morgan, Jeremy Nix, Sawona Biswas, Tracy A. Glauser, Paul Avillach, Sek Won Kong, Niloofar Jalali, Jeremy J. Corsmo, Anna Bartels, Amy Kratchman, Bria Morgan

Publikováno v: Genetics in Medicine

Purpose Clinicians and researchers must contextualize a patient’s genetic variants against population-based references with detailed phenotyping. We sought to establish globally scalable technology, policy, and procedures for sharing biosamples and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bcf3e4ee8562cecd775d190e3d12ad
https://doi.org/10.1038/s41436-019-0646-3