Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Michal, Jurášek"'
Autor:
Jiří Řehulka, Michal Jurášek, Pavel Dráber, Aleksandra Ivanová, Soňa Gurská, Kateřina Ječmeňová, Olena Mokshyna, Marián Hajdúch, Pavel Polishchuk, Pavel B. Drašar, Petr Džubák
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Estradiol dimers (EDs) possess significant anticancer activity by targeting tubulin dynamics. In this study, we synthesised 12 EDs variants via copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction, focusing on structural modifications within
Externí odkaz:
https://doaj.org/article/c6ffcd1be2c54765a90525facd8c6a33
Autor:
Jarmila Králová, Michal Jurášek, Lucie Mikšátková, Anna Marešová, Jan Fähnrich, Petra Cihlářová, Pavel Drašar, Petr Bartůněk, Vladimír Král
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Fluorescent sterol probes, comprising a fluorophore connected to a sterol backbone by means of a linker, are promising tools for enabling high-resolution imaging of intracellular cholesterol. In this study, we evaluated how the size of the l
Externí odkaz:
https://doaj.org/article/9f4dc5143084469ea4450e9de614eba2
Autor:
Silvie Rimpelová, Michal Jurášek, Lucie Peterková, Jiří Bejček, Vojtěch Spiwok, Miloš Majdl, Michal Jirásko, Miloš Buděšínský, Juraj Harmatha, Eva Kmoníčková, Pavel Drašar, Tomáš Ruml
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 1933-1944 (2019)
Sesquiterpene lactones are secondary plant metabolites with sundry biological effects. In plants, they are synthesized, among others, for pesticidal and antimicrobial effects. Two such compounds, archangelolide and trilobolide of the guaianolide type
Externí odkaz:
https://doaj.org/article/e0555971933f45a6b2c7b8b8a83ca8e5
Publikováno v:
Chemické listy. 116:668-671
As a component of drinks, food, cosmetics, and spice, hops yields a plethora of biologically active compounds. This plant, which was valued by gods and kings through the history, may serve as a basis for pharmaceutical exploitation: not only as a hea
Heterocyclic sterol probes for live monitoring of sterol trafficking and lysosomal storage disorders
Autor:
Jarmila Králová, Michal Jurášek, Lucie Krčová, Bohumil Dolenský, Ivan Novotný, Michal Dušek, Zdeňka Rottnerová, Michal Kahle, Pavel Drašar, Petr Bartůněk, Vladimír Král
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract The monitoring of intracellular cholesterol homeostasis and trafficking is of great importance because their imbalance leads to many pathologies. Reliable tools for cholesterol detection are in demand. This study presents the design and synt
Externí odkaz:
https://doaj.org/article/0647f34dfb5f4375bc68e664338d2298
Publikováno v:
Sensors, Vol 22, Iss 1, p 4 (2021)
Anabolic-androgenic steroids (AASs), a group of compounds frequently misused by athletes and, unfortunately, also by the general population, have lately attracted global attention; thus, significant demands for more precise, facile, and rapid AAS det
Externí odkaz:
https://doaj.org/article/0a949b259a474dc8b076a510f76431e6
Autor:
David Kodr, Jarmila Stanková, Michaela Rumlová, Petr Džubák, Jiří Řehulka, Tomáš Zimmermann, Ivana Křížová, Soňa Gurská, Marián Hajdúch, Pavel B. Drašar, Michal Jurášek
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1104 (2021)
Betulinic acid (BA) is a potent triterpene, which has shown promising potential in cancer and HIV-1 treatment. Here, we report a synthesis and biological evaluation of 17 new compounds, including BODIPY labelled analogues derived from BA. The analogu
Externí odkaz:
https://doaj.org/article/5e863bb72c9b49ad97b6593f6a49c8e3
Publikováno v:
Toxins, Vol 13, Iss 5, p 344 (2021)
Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation. Interestingly,
Externí odkaz:
https://doaj.org/article/039fc62d14de443da660bbae7d3c17b0
Autor:
Ludmila Škorpilová, Silvie Rimpelová, Michal Jurášek, Miloš Buděšínský, Jana Lokajová, Roman Effenberg, Petr Slepička, Tomáš Ruml, Eva Kmoníčková, Pavel B. Drašar, Zdeněk Wimmer
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 1316-1324 (2017)
Like thapsigargin, which is undergoing clinical trials, trilobolide is a natural product with promising anticancer and anti-inflammatory properties. Similar to thapsigargin, it has limited aqueous solubility that strongly reduces its potential medici
Externí odkaz:
https://doaj.org/article/95b5cb3f615e43038cb837ada69890f5
Autor:
Barbora Holubová, Pavla Kubešová, Lukáš Huml, Miroslav Vlach, Oldřich Lapčík, Michal Jurášek, Ladislav Fukal
Publikováno v:
Foods, Vol 10, Iss 4, p 741 (2021)
In recent years, the undeclared presence of various anabolic androgenic steroids (AAS) in commercial supplements has been confirmed. This fact can be a potential threat to all athletes using these supplements, and therefore, there is of increased int
Externí odkaz:
https://doaj.org/article/5fd1032ee0f340c6883987bb0bd93bc2