Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks

Autor: Michal Dudek, Dharshika R. J. Pathiranage, Beatriz Bano-Otalora, Anna Paszek, Natalie Rogers, Cátia F. Gonçalves, Craig Lawless, Dong Wang, Zhuojing Luo, Liu Yang, Farshid Guilak, Judith A. Hoyland, Qing-Jun Meng

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract Daily rhythms in mammalian behaviour and physiology are generated by a multi-oscillator circadian system entrained through environmental cues (e.g. light and feeding). The presence of tissue niche-dependent physiological time cues has been p

Externí odkaz: https://doaj.org/article/9e210009537f41aeac826a1fa19c039e

Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration

Autor: Dong Wang, Pandi Peng, Michal Dudek, Xueyu Hu, Xiaolong Xu, Qiliang Shang, Di Wang, Haoruo Jia, Han Wang, Bo Gao, Chao Zheng, Jianxin Mao, Chu Gao, Xin He, Pengzhen Cheng, Huanbo Wang, Jianmin Zheng, Judith A. Hoyland, Qing-Jun Meng, Zhuojing Luo, Liu Yang

Publikováno v: Bone Research, Vol 10, Iss 1, Pp 1-13 (2022)

Abstract The circadian clock participates in maintaining homeostasis in peripheral tissues, including intervertebral discs (IVDs). Abnormal mechanical loading is a known risk factor for intervertebral disc degeneration (IDD). Based on the rhythmic da

Externí odkaz: https://doaj.org/article/820dbe45e90145688af0d89d7a9a2294

The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc

Autor: Michal Dudek, Honor Morris, Natalie Rogers, Dharshika RJ Pathiranage, Danny Chan, Karl E Kadler, Judith Hoyland, Qing-Jun Meng

The circadian clock in mammals temporally coordinates physiological and behavioural processes to anticipate daily rhythmic changes in their environment. Chronic disruption to circadian rhythms (e.g., through ageing or shift work) is thought to contri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6058cc6fbc6edd7965e3d8bdc659ad5
https://doi.org/10.1101/2023.02.12.528214

Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1–induced inflammation

Autor: Lara Pferdehirt, Anna R. Damato, Michal Dudek, Qing-Jun Meng, Erik D. Herzog, Farshid Guilak

Publikováno v: Pferdehirt, L, Damato, A R, Dudek, M, Meng, Q-J, Herzog, E D & Guilak, F 2022, ' Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1–induced inflammation ', Science Advances . https://doi.org/10.1126/sciadv.abj8892, https://doi.org/doi: 10.1126/sciadv.abj8892

The circadian clock regulates tissue homeostasis through temporal control of tissue-specific clock-controlled genes. In articular cartilage, disruptions in the circadian clock are linked to a procatabolic state. In the presence of inflammation, the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba24107df8c268546c7e40ef3f418be0
https://doi.org/10.1126/sciadv.abj8892

Circadian time series proteomics reveals daily dynamics in cartilage physiology

Autor: Venkatesh Mallikarjun, Dharshika Pathiranage, Qing-Jun Meng, John F. Bateman, Constanza Angelucci, Ping Wang, Shireen R. Lamandé, Judith A. Hoyland, Karl E. Kadler, Michal Dudek, Craig Lawless, Raymond P. Boot-Handford, Joe Swift

Publikováno v: Osteoarthritis and Cartilage

Summary Objective Cartilage in joints such as the hip and knee experiences repeated phases of heavy loading and low load recovery during the 24-h day/night cycle. Our previous work has shown 24 h rhythmic changes in gene expression at transcript leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326f7e51dbcefac540520ebf58d00503
http://europepmc.org/articles/PMC8113022