Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Michail N, Isupov"'
Autor:
Matthew C. Gaines, Shamphavi Sivabalasarma, Michail N. Isupov, Risat Ul Haque, Mathew McLaren, Cyril Hanus, Vicki A. M. Gold, Sonja-Verena Albers, Bertram Daum
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Amongst the major types of archaeal filaments, several have been shown to closely resemble bacterial homologues of the Type IV pili (T4P). Within Sulfolobales, member species encode for three types of T4P, namely the archaellum, the UV-induc
Externí odkaz:
https://doaj.org/article/e67bb064dfe2460a976486655a1a4482
Autor:
Lavinia Gambelli, Mathew McLaren, Rebecca Conners, Kelly Sanders, Matthew C Gaines, Lewis Clark, Vicki AM Gold, Daniel Kattnig, Mateusz Sikora, Cyril Hanus, Michail N Isupov, Bertram Daum
Publikováno v:
eLife, Vol 13 (2024)
Surface layers (S-layers) are resilient two-dimensional protein lattices that encapsulate many bacteria and most archaea. In archaea, S-layers usually form the only structural component of the cell wall and thus act as the final frontier between the
Externí odkaz:
https://doaj.org/article/42b28b40f3aa4a40a7d545c8974c8522
Autor:
Simone A. De Rose, Michail N. Isupov, Harley L. Worthy, Christina Stracke, Nicholas J. Harmer, Bettina Siebers, Jennifer A. Littlechild, The HotSolute consortium, Christopher Bräsen, Benjamin Meyer, Simone Antonio De Rose, Jennifer Ann Littlechild, Elizaveta Bonch-Osmolovskaya, Sergey Gavrilov, Ilya Kublanov, Daniela Monti, Erica Ferrandi, Eleonora Dore, Felix Müller, Jacky Snoep
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The enzyme cyclic di-phosphoglycerate synthetase that is involved in the production of the osmolyte cyclic 2,3-diphosphoglycerate has been studied both biochemically and structurally. Cyclic 2,3-diphosphoglycerate is found exclusively in the hyperthe
Externí odkaz:
https://doaj.org/article/c43883716fda42c0bf71faf709f2430c
Autor:
Tami Khazma, Atira Grossman, Julia Guez-Haddad, Chengye Feng, Hadas Dabas, Radhika Sain, Michal Weitman, Ran Zalk, Michail N. Isupov, Marc Hammarlund, Michael Hons, Yarden Opatowsky
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113026- (2023)
Summary: Wallerian axonal degeneration (WD) does not occur in the nematode C. elegans, in contrast to other model animals. However, WD depends on the NADase activity of SARM1, a protein that is also expressed in C. elegans (ceSARM/ceTIR-1). We hypoth
Externí odkaz:
https://doaj.org/article/7e3ef32d28c44b7ebf562503fb102f11
Autor:
Matthew C. Gaines, Michail N. Isupov, Shamphavi Sivabalasarma, Risat Ul Haque, Mathew McLaren, Clara L. Mollat, Patrick Tripp, Alexander Neuhaus, Vicki A. M. Gold, Sonja-Verena Albers, Bertram Daum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Pili are filamentous appendages on the surface of bacteria and archaea, and play roles in multiple processes such as adhesion, motility and horizontal gene transfer. Here, Gaines et al. describe the structure of a new type of pilus, termed ‘thread
Externí odkaz:
https://doaj.org/article/c999b454003945b89a4580142f7659c6
Autor:
Lavinia Gambelli, Michail N. Isupov, Rebecca Conners, Mathew McLaren, Annett Bellack, Vicki Gold, Reinhard Rachel, Bertram Daum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The archaellum is a molecular machine used by archaea to swim, consisting of an intracellular motor that drives the rotation of an extracellular filament composed of multiple copies of proteins named archaellins. Here, the authors use electron cryo-m
Externí odkaz:
https://doaj.org/article/6f18740a93994ed48c9866aa8a523f82
Autor:
Manoj Kumar, Prasanth Padala, Jamal Fahoum, Fouad Hassouna, Tomer Tsaban, Guy Zoltsman, Sayanika Banerjee, Einav Cohen-Kfir, Moshe Dessau, Rina Rosenzweig, Michail N. Isupov, Ora Schueler-Furman, Reuven Wiener
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Ufmylation is a well-established ubiquitin-like protein modification, but its mechanism is largely unclear. Here, the authors present a crystal structure of the ufmylation-specific E1-E2 complex, revealing differences to the ubiquitination machinery
Externí odkaz:
https://doaj.org/article/92a7bec4aca04541b5ce9c87607504cd
Autor:
Jan-Moritz Sutter, Daniel E. Mitchell, Marcel Schmidt, Michail N. Isupov, Jennifer A. Littlechild, Peter Schönheit
Publikováno v:
Frontiers in Catalysis, Vol 2 (2022)
A branched chain aminotransferase from Thermoproteus tenax has been identified, cloned, over-expressed and biochemically characterised. A molecular modelling approach has been used to predict the 3D structure allowing its comparison with other relate
Externí odkaz:
https://doaj.org/article/3134fe04d7bc4c0ca2eda41e791427f3
Autor:
Simone Antonio De Rose, Tom Kuprat, Michail N. Isupov, Andreas Reinhardt, Peter Schönheit, Jennifer A. Littlechild
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
A novel D-lyxose isomerase has been identified within the genome of a hyperthermophilic archaeon belonging to the Thermofilum species. The enzyme has been cloned and over-expressed in Escherichia coli and biochemically characterised. This enzyme diff
Externí odkaz:
https://doaj.org/article/f6b8d8f8a86a497faa268ce216468c62
Autor:
Michael Sporny, Julia Guez-Haddad, Tami Khazma, Avraham Yaron, Moshe Dessau, Yoel Shkolnisky, Carsten Mim, Michail N Isupov, Ran Zalk, Michael Hons, Yarden Opatowsky
Publikováno v:
eLife, Vol 9 (2020)
SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its activation under stress conditions are still unknown. Here, we pre
Externí odkaz:
https://doaj.org/article/757a57e42bd944929c69f7eff4349681