Mechanism, scaling and rates of protein aggregation from in vivo measurements

Autor: Meisl, Georg, Dear, Alexander J, Michaels, Thomas CT, Knowles, Tuomas PJ

The formation and proliferation of protein aggregates play a central role in a number of devastating neuro-degenerative diseases. Many experimental studies indicate that the ability of existing aggregates to replicate is a key property in generating

Externí odkaz: http://arxiv.org/abs/2008.09699

Analytical Solution to the Flory-Huggins Model

Autor: Qian, Daoyuan, Michaels, Thomas CT, Knowles, Tuomas PJ

Funder: Frances and Augustus Newman Foundation
Funder: Laboratory for Molecular Cell Biology, University College London
Funder: Biotechnology and Biological Sciences Research Council
A self-consistent analytical solution for binodal co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af7adc68f28dd47a4d86f7d0a5fcd78
https://www.repository.cam.ac.uk/handle/1810/341128

Universality of filamentous aggregation phenomena

Autor: Michaels, Thomas CT, Dear, Alexander J, Knowles, Tuomas PJ

We use perturbative renormalization group theory to study the kinetics of protein aggregation phenomena in a unified manner across multiple timescales. Using this approach, we find that, irrespective of the specific molecular details or experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a5b8b483c78726790ceb4d4f1c0ed5

Physical Determinants of Amyloid Assembly in Biofilm Formation

Autor: Andreasen, Maria, Meisl, Georg, Taylor, Jonathan D, Michaels, Thomas CT, Levin, Aviad, Otzen, Daniel E, Chapman, Matthew R, Dobson, Christopher M, Matthews, Steve J, Knowles, Tuomas PJ

Publikováno v: Andreasen, M, Meisl, G, Taylor, J D, Michaels, T C T, Levin, A, Otzen, D E, Chapman, M R, Dobson, C M, Matthews, S J & Knowles, T P J 2019, ' Physical Determinants of Amyloid Assembly in Biofilm Formation ', mBio, vol. 10, no. 1, e02279-18 . https://doi.org/10.1128/mBio.02279-18
mBio, Vol 10, Iss 1 (2019)
mBio, Vol 10, Iss 1, p e02279-18 (2019)

A wide range of bacterial pathogens have been shown to form biofilms, which significantly increase their resistance to environmental stresses, such as antibiotics, and are thus of central importance in the context of bacterial diseases. One of the ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bfeebe7ba5776cbc5adca699605a71
https://pure.au.dk/portal/da/publications/physical-determinants-of-amyloid-assembly-in-biofilm-formation(91bf63ce-237e-45be-9064-f7d057f0405c).html

Quantifying Co-Oligomer Formation by α-Synuclein

Autor: Iljina, Marija, Dear, Alexander J, Garcia, Gonzalo A, De, Suman, Tosatto, Laura, Flagmeier, Patrick, Whiten, Daniel R, Michaels, Thomas CT, Frenkel, Daan, Dobson, Christopher M, Knowles, Tuomas PJ, Klenerman, David

Small oligomers of the protein α-synuclein (αS) are highly cytotoxic species associated with Parkinson's disease (PD). In addition, αS can form co-aggregates with its mutational variants and with other proteins such as amyloid-β (Aβ) and tau, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2708ae4273c1b536cf23fb375aaa9a33