Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Michaeline L, Hebron"'
Autor:
Max Stevenson, Rency Varghese, Michaeline L. Hebron, Xiaoguang Liu, Nick Ratliff, Amelia Smith, R. Scott Turner, Charbel Moussa
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals diagnosed with mild–moderate Alzheimer’s disease (AD) treated
Externí odkaz:
https://doaj.org/article/e25ad3d27a9d4b9aa56025dd33e019df
Autor:
Fernando L. Pagan, Yasar Torres‐Yaghi, Michaeline L. Hebron, Barbara Wilmarth, R. Scott Turner, Sara Matar, Dalila Ferrante, Jaeil Ahn, Charbel Moussa
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Bosutinib, a dual Abelson/Src inhibitor, was investigated in individuals with dementia with Lewy bodies (DLB). Methods A single site, randomized, double‐blind, placebo‐controlled study of the effects of oral bosutinib, 100 m
Externí odkaz:
https://doaj.org/article/003e9803bd3344659874b1f34a070969
Autor:
Karen E. Anderson, Max Stevenson, Rency Varghese, Michaeline L. Hebron, Erin Koppel, Mara McCartin, Robin Kuprewicz, Sara Matar, Dalila Ferrante, Charbel Moussa
Publikováno v:
Metabolites, Vol 12, Iss 12, p 1225 (2022)
Nilotinib is a tyrosine kinase inhibitor that is safe and tolerated in neurodegeneration, it achieves CSF concentration that is adequate to inhibit discoidin domain receptor (DDR)-1. Nilotinib significantly affects dopamine metabolites, including Hom
Externí odkaz:
https://doaj.org/article/cdae29a63dc94b07820a577e6b24285d
Autor:
Irina Lonskaya, Michaeline L. Hebron, Nicole M. Desforges, Alexander Franjie, Charbel E.‐H. Moussa
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 8, Pp 1247-1262 (2013)
Abstract Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β‐amyloid (plaques) and hyper‐phosphorylated Tau (tangles). Here we show that AD animals
Externí odkaz:
https://doaj.org/article/3d80c6d017dd48f3ab00f397b9f09b1c
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83914 (2013)
Parkinson's disease (PD) is a movement disorder associated with genetic and age related causes. Although autosomal recessive early onset PD linked to parkin mutations does not exhibit α-Synuclein accumulation, while autosomal dominant and sporadic P
Externí odkaz:
https://doaj.org/article/de24d38fa6414632884870c717a99b17
Autor:
Nicole M. Desforges, Michaeline L. Hebron, Norah K. Algarzae, Irina Lonskaya, Charbel E.-H. Moussa
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2012 (2012)
The role of inflammation in neurodegenerative diseases has been widely demonstrated. Intraneuronal protein accumulation may regulate microglial activity via the fractalkine (CX3CL1) signaling pathway that provides a mechanism through which neurons co
Externí odkaz:
https://doaj.org/article/55e4843ff7b844b9b97d84adce2460d5