Integrins synergize to induce expression of the MRTF-A/SRF target gene ISG15 for promoting cancer cell invasion

Autor: Madis Jakobson, Guido Posern, Maili Jakobson, Georgina P. Colo, Reinhard Fässler, Emanuel Rognoni, Christian Kupatt, Michaela-Rosemarie Hermann

Publikováno v: Journal of Cell Science.

Integrin-mediated activation of small GTPases induces the polymerisation of G-actin into various actin structures and the release of the transcriptional co-activator MRTF from G-actin. Here we report that pan-integrin-null fibroblasts seeded on fibro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482c3a4e67dae4fbe83ffcc52e150ec1
https://doi.org/10.1242/jcs.177592

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

Autor: Reinhard Fässler, Zhiqi Sun, Julien Polleux, Michaela-Rosemarie Hermann, Timothée Vignaud, Caroline C. Friedel, Manuel Théry, Herbert B. Schiller, Sara Zanivan, Matthias Mann, Aurelia Raducanu, Kay-E. Gottschalk

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2013, 15 (6), pp.625-36. ⟨10.1038/ncb2747⟩
Nature Cell Biology, 2013, 15 (6), pp.625-36. ⟨10.1038/ncb2747⟩

Supplementary information; International audience; How different integrins that bind to the same type of extracellular matrix protein mediate specific functions is unclear. We report the functional analysis of β1- and αv-class integrins expressed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8712a7191a162fed92784e0445649d2e
https://pubmed.ncbi.nlm.nih.gov/23756622