Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Michaela Vaskovicova"'
Autor:
Jan Nevoral, David Drutovic, Michaela Vaskovicova, Michal Benc, Frantisek Liska, Iveta Valentova, Sara Stachovicova, Jan Kubovciak, Jirina Havrankova, Miki Shavit, Ladan Monsef, Maria Iniesta-Cuerda, Tereza Zalmanova, Petr Hosek, Frantisek Strejcek, Milena Kralickova, Jaroslav Petr
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some
Externí odkaz:
https://doaj.org/article/4ecb423c44094011900754b30a2f4d9c
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110451- (2024)
Summary: Meiotic spindles are critical to ensure chromosome segregation during gamete formation. Oocytes lack centrosomes and use alternative microtubule-nucleation mechanisms for spindle building. How these mechanisms are regulated is still unknown.
Externí odkaz:
https://doaj.org/article/d959401b658d4100b8b7648a8005171c
Autor:
Cecilia S Blengini, Patricia Ibrahimian, Michaela Vaskovicova, David Drutovic, Petr Solc, Karen Schindler
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009327 (2021)
The Aurora protein kinases are well-established regulators of spindle building and chromosome segregation in mitotic and meiotic cells. In mouse oocytes, there is significant Aurora kinase A (AURKA) compensatory abilities when the other Aurora kinase
Externí odkaz:
https://doaj.org/article/9d1c6263a80f402885340ae889dfeed1
Autor:
Michaela Vaskovicova, Patricia Ibrahimian, Petr Solc, Karen Schindler, Cecilia S. Blengini, David Drutovic
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009327 (2021)
PLoS Genetics
PLoS Genetics
The Aurora protein kinases are well-established regulators of spindle building and chromosome segregation in mitotic and meiotic cells. In mouse oocytes, there is significant Aurora kinase A (AURKA) compensatory abilities when the other Aurora kinase
Autor:
Ivana Ferencova, Michaela Vaskovicova, David Drutovic, Lucie Knoblochova, Libor Macurek, Richard M. Schultz, Petr Solc
Publikováno v:
Journal of cell science. 135(6)
Mammalian oocytes are arrested at meiotic prophase I. The dual-specificity phosphatase CDC25B is essential for cyclin-dependent kinase 1 (CDK1) activation that drives resumption of meiosis. CDC25B reverses the inhibitory effect of the protein kinases
Autor:
Ewa Pavlova, N. Dvorakova, S. S. Rohiwal, D. Babuka, Miroslav Šlouf, Michaela Vaskovicova, Knut Stieger, H. Benes, P. Stepanek, Jiří Klíma, Filip Šenigl, Zdenka Ellederova
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Clustered regularly interspaced short palindromic repeats-associated protein (CRISPR/Cas9) system has become a revolutionary tool for gene editing. Since viral delivery systems have significant side effects, and naked DNA delivery is not an option, t
Autor:
Michaela Vaskovicova, Georgina Askeland, Jan Motlik, Zdenka Ellederova, Petra Smatlikova, Lars Eide, Jiri Klima
Background: Huntington’s disease (HD) is a devastating neurodegenerative disorder caused by CAG triplet expansions in the huntingtin gene. Oxidative stress is linked to HD pathology, although it is not clear whether this is an effect or a mediator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd1733e843b1db5b5e5a68fde76527f
http://hdl.handle.net/10852/74875
http://hdl.handle.net/10852/74875
Autor:
Filip Horvat, Michaela Vaskovicova, Josef Pasulka, Petr Svoboda, Matyas Flemr, Tomas Demeter, Eliska Svobodova, Radek Malik
Publikováno v:
Life Science Alliance
A systematic survey of dsRNA expression in mouse fibroblasts and embryonic stem cells shows main constraints for RNAi. RNAi activity depends on the initial Dicer cleavage of dsRNA, having implications for the evolution of mammalian RNAi functions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fafe5de371954fde983ce0dee7a548
https://doi.org/10.1101/485524
https://doi.org/10.1101/485524
Autor:
Georgina Askeland, Jan Motlik, Lars Eide, Jiri Klima, Petra Smatlikova, Michaela Vaskovicova, Zdenka Ellederova
Publikováno v:
Pathogenic mechanisms.
Background Huntington´s disease (HD) is devastating neurodegenerative disorder caused by the mutation in huntingtin gene. One of the largest contributors to HD pathology represents oxidative stress, though the exact mechanism of its cause remains un
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A10.3-A11
Background Huntington’s disease (HD) is progressive neurodegenerative disorder caused by the mutation in the huntingtin gene giving rise to mutated form of huntingtin protein (mHTT). Recent findings suggest that mHTT may also affect DNA damage resp