Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Michaela Rumlová"'
Autor:
Martin Selinger, Pavlína Věchtová, Hana Tykalová, Petra Ošlejšková, Michaela Rumlová, Ján Štěrba, Libor Grubhoffer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2759-2777 (2022)
Tick-borne encephalitis virus (TBEV), the most medically relevant tick-transmitted flavivirus in Eurasia, targets the host central nervous system and frequently causes severe encephalitis. The severity of TBEV-induced neuropathogenesis is highly cell
Externí odkaz:
https://doaj.org/article/86a306273e9145be900383d97905308f
Autor:
Ivana Křížová, Alžběta Dostálková, Edison Castro, Jan Prchal, Romana Hadravová, Filip Kaufman, Richard Hrabal, Tomáš Ruml, Manuel Llano, Luis Echegoyen, Michaela Rumlová
Publikováno v:
Viruses, Vol 14, Iss 6, p 1187 (2022)
The authors wish to make the following corrections to this paper [...]
Externí odkaz:
https://doaj.org/article/a51695288a8b4283aaa1221b96ae43da
Autor:
Michal Maryška, Lucie Svobodová, Wim Dehaen, Martina Hrabinová, Michaela Rumlová, Ondřej Soukup, Martin Kuchař
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1291 (2021)
Kynurenic acid is a neuroprotective metabolite of tryptophan formed by kynurenine aminotransferase (KAT) catalyzed transformation of kynurenine. However, its high brain levels are associated with cognitive deficit and with the pathophysiology of schi
Externí odkaz:
https://doaj.org/article/35ee767a83e84b3da50a05098aaeabdc
Autor:
Ivana Křížová, Alžběta Dostálková, Edison Castro, Jan Prchal, Romana Hadravová, Filip Kaufman, Richard Hrabal, Tomáš Ruml, Manuel Llano, Luis Echegoyen, Michaela Rumlová
Publikováno v:
Viruses, Vol 13, Iss 12, p 2451 (2021)
Fullerene derivatives with hydrophilic substituents have been shown to exhibit a range of biological activities, including antiviral ones. For a long time, the anti-HIV activity of fullerene derivatives was believed to be due to their binding into th
Externí odkaz:
https://doaj.org/article/67c6db1509574c1fa4c386f11f6081e1
Autor:
Martina Koncošová, Nikola Vrzáčková, Ivana Křížová, Petra Tomášová, Silvie Rimpelová, Aleš Dvořák, Libor Vítek, Michaela Rumlová, Tomáš Ruml, Jaroslav Zelenka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10790 (2021)
Metabolic transformation of cancer cells leads to the accumulation of lactate and significant acidification in the tumor microenvironment. Both lactate and acidosis have a well-documented impact on cancer progression and negative patient prognosis. H
Externí odkaz:
https://doaj.org/article/d13c14460b754717b47f78c8a590d280
Autor:
David Kodr, Jarmila Stanková, Michaela Rumlová, Petr Džubák, Jiří Řehulka, Tomáš Zimmermann, Ivana Křížová, Soňa Gurská, Marián Hajdúch, Pavel B. Drašar, Michal Jurášek
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1104 (2021)
Betulinic acid (BA) is a potent triterpene, which has shown promising potential in cancer and HIV-1 treatment. Here, we report a synthesis and biological evaluation of 17 new compounds, including BODIPY labelled analogues derived from BA. The analogu
Externí odkaz:
https://doaj.org/article/5e863bb72c9b49ad97b6593f6a49c8e3
Autor:
Alžběta Dostálková, Barbora Vokatá, Filip Kaufman, Pavel Ulbrich, Tomáš Ruml, Michaela Rumlová
Publikováno v:
Viruses, Vol 13, Iss 1, p 129 (2021)
The assembly of a hexameric lattice of retroviral immature particles requires the involvement of cell factors such as proteins and small molecules. A small, negatively charged polyanionic molecule, myo-inositol hexaphosphate (IP6), was identified to
Externí odkaz:
https://doaj.org/article/cf5ab87f2bc541c8b19e5268dc82e508
Autor:
Veronika Vetyskova, Monika Zouharova, Lucie Bednarova, Ondřej Vaněk, Petra Sázelová, Václav Kašička, Jiri Vymetal, Jaroslav Srp, Michaela Rumlová, Tatsiana Charnavets, Klara Postulkova, Janne E. Reseland, Kristyna Bousova, Jiri Vondrasek
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9293 (2020)
Ameloblastin (Ambn) as an intrinsically disordered protein (IDP) stands for an important role in the formation of enamel—the hardest biomineralized tissue commonly formed in vertebrates. The human ameloblastin (AMBN) is expressed in two isoforms: f
Externí odkaz:
https://doaj.org/article/ef38b291810f497a8957145ed565b8c2
Autor:
Alžběta Dostálková, Kryštof Škach, Filip Kaufman, Ivana Křížová, Romana Hadravová, Martin Flegel, Tomáš Ruml, Richard Hrabal, Michaela Rumlová
Publikováno v:
Molecules, Vol 25, Iss 8, p 1895 (2020)
A major structural retroviral protein, capsid protein (CA), is able to oligomerize into two different hexameric lattices, which makes this protein a key component for both the early and late stages of HIV-1 replication. During the late stage, the CA
Externí odkaz:
https://doaj.org/article/b939cbe2ed61412b9750765f6dc6167b
Autor:
Petra Grznárová Prokšová, Jan Lipov, Jaroslav Zelenka, Eric Hunter, Hana Langerová, Michaela Rumlová, Tomáš Ruml
Publikováno v:
Viruses, Vol 10, Iss 10, p 575 (2018)
The envelope glycoprotein (Env) plays a crucial role in the retroviral life cycle by mediating primary interactions with the host cell. As described previously and expanded on in this paper, Env mediates the trafficking of immature Mason-Pfizer monke
Externí odkaz:
https://doaj.org/article/7e1caa1b91744a66a81c0fd852546ffb