Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Michaela Rath"'
Autor:
Simran Chopra, Otsuware Linda-Josephine Kadiri, Jannis Ulke, Robert Hauffe, Wenke Jonas, Sahar Cheshmeh, Luisa Schmidt, Christopher A. Bishop, Selma Yagoub, Mareike Schell, Michaela Rath, Janine Krüger, Rachel N. Lippert, Marcus Krüger, Kai Kappert, André Kleinridders
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 114984- (2024)
Summary: A healthy metabolism relies on precise regulation of anabolic and catabolic pathways. While insulin deficiency impairs anabolism, insulin resistance in obesity causes metabolic dysfunction, especially via altered brain insulin receptor (IR)
Externí odkaz:
https://doaj.org/article/64bbfe6718224c24ba3e8e674c800a6a
Autor:
Robert Hauffe, Michaela Rath, Mareike Schell, Katrin Ritter, Kai Kappert, Stefanie Deubel, Christiane Ott, Markus Jähnert, Wenke Jonas, Annette Schürmann, André Kleinridders
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101276- (2021)
Objective: Insulin regulates mitochondrial function, thereby propagating an efficient metabolism. Conversely, diabetes and insulin resistance are linked to mitochondrial dysfunction with a decreased expression of the mitochondrial chaperone HSP60. Th
Externí odkaz:
https://doaj.org/article/8e70c968a1694ff39c2a66f6cc5ab0a2
Autor:
Kristina Wardelmann, Sabine Blümel, Michaela Rath, Eugenia Alfine, Chantal Chudoba, Mareike Schell, Weikang Cai, Robert Hauffe, Kathrin Warnke, Tanina Flore, Katrin Ritter, Jürgen Weiß, C. Ronald Kahn, André Kleinridders
Publikováno v:
Molecular Metabolism, Vol 21, Iss , Pp 68-81 (2019)
Objective: Insulin action in the brain controls metabolism and brain function, which is linked to proper mitochondrial function. Conversely, brain insulin resistance associates with mitochondrial stress and metabolic and neurodegenerative diseases. I
Externí odkaz:
https://doaj.org/article/7c9d14609d4c4b8591384c45fafcc306
Autor:
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Blüher, André Kleinridders
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 862 (2022)
The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selenoproteins,
Externí odkaz:
https://doaj.org/article/f0df0dd7af6b4c95b7dab059e4dcf45b
Autor:
André Kleinridders, Heather A. Ferris, Michelle L. Reyzer, Michaela Rath, Marion Soto, M. Lisa Manier, Jeffrey Spraggins, Zhihong Yang, Robert C. Stanton, Richard M. Caprioli, C. Ronald Kahn
Publikováno v:
Molecular Metabolism, Vol 12, Iss , Pp 113-121 (2018)
Objective: Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and hyperglycemia resulting in acute outcomes ranging from confusion to seizures, while chroni
Externí odkaz:
https://doaj.org/article/e3b3bf9b3ec147769c0344d2c9e1cbb6
Autor:
Kristina Wardelmann, Michaela Rath, José Pedro Castro, Sabine Blümel, Mareike Schell, Robert Hauffe, Fabian Schumacher, Tanina Flore, Katrin Ritter, Andreas Wernitz, Toru Hosoi, Koichiro Ozawa, Burkhard Kleuser, Jürgen Weiß, Annette Schürmann, André Kleinridders
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 711 (2021)
Mitochondria are critical for hypothalamic function and regulators of metabolism. Hypothalamic mitochondrial dysfunction with decreased mitochondrial chaperone expression is present in type 2 diabetes (T2D). Recently, we demonstrated that a dysregula
Externí odkaz:
https://doaj.org/article/9db7b1040f554f3f80b1b7f6dd84a90e
Autor:
Mareike Schell, Kristina Wardelmann, Robert Hauffe, Michaela Rath, Simran Chopra, André Kleinridders
Publikováno v:
Biological Psychiatry Global Open Science.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::453e0292ed428034d9fd3ed46e64bf3b
https://doi.org/10.1016/j.bpsgos.2023.02.011
https://doi.org/10.1016/j.bpsgos.2023.02.011
Autor:
MAREIKE SCHELL, KRISTINA WARDELMANN, ROBERT HAUFFE, MICHAELA RATH, SIMRAN CHOPRA, ANDRE KLEINRIDDERS
Publikováno v:
Diabetes. 71
Prevalence of depression is higher in diabetic patients compared to healthy humans due to a shared pathogenesis including insulin resistance and inflammation. These factors are also linked to intestinal dysbiosis. Interestingly, preventive intake of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::065ed94413391fce0406460f6957be4e
https://doi.org/10.2337/db22-1398-p
https://doi.org/10.2337/db22-1398-p
Publikováno v:
Diabetes. 71
The loss of insulin receptor (IR) in white adipose tissue (WAT) is a feature of type 2 diabetes. Previously, we have demonstrated that feeding mice a preventive selenium rich HFD (SRHFD) , while not influencing obesity development, counteracted diet-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b57fb0abccebfc8db54b0f3a25ddc618
https://doi.org/10.2337/db22-145-or
https://doi.org/10.2337/db22-145-or
Autor:
Robert Hauffe, C. Ronald Kahn, Eugenia Alfine, Jürgen Weiß, Tanina Flore, Kathrin Warnke, Michaela Rath, Chantal Chudoba, Mareike Schell, Weikang Cai, Sabine Blümel, Kristina Wardelmann, Katrin Ritter, André Kleinridders
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 21, Iss, Pp 68-81 (2019)
Molecular Metabolism, Vol 21, Iss, Pp 68-81 (2019)
Objective Insulin action in the brain controls metabolism and brain function, which is linked to proper mitochondrial function. Conversely, brain insulin resistance associates with mitochondrial stress and metabolic and neurodegenerative diseases. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dade6296aa8efa96d27a5b18d41bee4c
https://doi.org/10.1016/j.molmet.2019.01.001
https://doi.org/10.1016/j.molmet.2019.01.001