Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michaela Prinz"'
Autor:
Adyary Fallarero, Gulsah Bayraktar, Pia Vuorela, Carola Schiller, Ezgi Turunc, Manuel Krug, Sülünay Parlar, Guliz Armagan, Ayfer Yalcin, Vildan Alptüzün, Christoph A. Sotriffer, Kristina Leuner, Daniela Karlsson, Malgorzata Burek, Michaela Prinz, Ulrike Holzgrabe, Ercin Erciyas, Carola Förster
Publikováno v:
European Journal of Pharmaceutical Sciences. 49:603-613
Given the fundamentally multifactorial character of Alzheimer's disease (AD), addressing more than one target for disease modification or therapy is expected to be highly advantageous. Here, following the cholinergic hypothesis, we aimed to inhibit b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a2933633e6fc31f6477b0ff4f6452a
https://doi.org/10.1016/j.ejps.2013.04.024
https://doi.org/10.1016/j.ejps.2013.04.024
Autor:
Michalina Ignasik, Marek Bajda, Natalia Guzior, Ulrike Holzgrabe, Barbara Malawska, Michaela Prinz
Publikováno v:
Archiv der Pharmazie. 345:509-516
A new series of 2-(diethylaminoalkyl)-isoindoline-1,3-dione derivatives intended as dual binding site cholinesterase inhibitors were designed using molecular modeling and evaluated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b69f798826372e034b27e566646e22
https://doi.org/10.1002/ardp.201100423
https://doi.org/10.1002/ardp.201100423
Autor:
Michaela Prinz, Thomas Erker, Gerda Brunhofer, Przemyslaw Guzik, Adyary Fallarero, Daniela Karlsson, Pia Vuorela, Ulrike Holzgrabe
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 45(1-2)
In this contribution, a chemical collection of aromatic compounds was screened for inhibition on butyrylcholinesterase (BChE)’s hydrolase activity using Ellman’s reaction. A set of diarylimidazoles was identified as highly selective inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3576a06e4cc18ad27db18b4cdaf3b720
https://pubmed.ncbi.nlm.nih.gov/22108346
https://pubmed.ncbi.nlm.nih.gov/22108346
Autor:
Adyary Fallarero, Holger Braunschweig, Josef Scheiber, Pia Vuorela, Ercin Erciyas, Vildan Alptüzün, Krzysztof Radacki, Verena Hörr, Bernd Engels, Michaela Prinz, Ulrike Holzgrabe
Publikováno v:
Bioorganicmedicinal chemistry. 18(5)
Approved drugs for the treatment of Alzheimer's disease belong to the group of inhibitors of the acetylcholinesterase (AChE) and NMDA receptor inhibitors. However none of the drugs is able to combat or reverse the progression of the disease. Thus, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb8d546b14086865a6a653096756eb4
https://pubmed.ncbi.nlm.nih.gov/20149667
https://pubmed.ncbi.nlm.nih.gov/20149667