Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Michaela Norrbom"'
Autor:
Eric Norstrom, Jennifer L. Chang, Robert A. Marr, Frank Rigo, Brandon Roman, Michelle L. Hastings, Anthony J. Hinrich, Michaela Norrbom
Publikováno v:
Molecular Therapy. 26:1539-1551
Alterations in amyloid beta precursor protein (APP) have been implicated in cognitive decline in Alzheimer's disease (AD), which is accelerated in Down syndrome/Trisomy 21 (DS/TS21), likely due to the extra copy of the APP gene, located on chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23629f184aa08e649d3cc68939f2629
https://doi.org/10.1016/j.ymthe.2018.02.029
https://doi.org/10.1016/j.ymthe.2018.02.029
Autor:
Sarah L. DeVos, Michaela Norrbom, Frank Rigo, C. Frank Bennett, Rebecca L. Miller, Seung J. Chun, David F. Wozniak, Kathleen M. Schoch, Hana N. Dawson, Timothy M. Miller
Publikováno v:
Neuron. 90:941-947
Pathological evidence for selective four repeat (4R) tau deposition in certain dementias and exon 10-positioned MAPT mutations together suggest a 4R-specific role in causing disease. However, direct assessments of 4R toxicity have not yet been accomp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492006de0e9c40ed235ebf7f41790725
https://doi.org/10.1016/j.neuron.2016.04.042
https://doi.org/10.1016/j.neuron.2016.04.042
Autor:
Zhongtian Liu, Daniel O'Reilly, Frank Rigo, Thazha P. Prakash, David R. Corey, Xiulong Shen, Michaela Norrbom, Liande Li, Vivek Sharma, Jonathan K. Watts, Masad J. Damha
Friedreich's Ataxia (FA) is an inherited neurologic disorder caused by an expanded GAA repeat within intron 1 of the frataxin (FXN) gene that reduces expression of FXN protein. Agents that increase expression of FXN have the potential to alleviate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3d7ff961a6343cb74eb4166bd1dfb7
https://europepmc.org/articles/PMC5790436/
https://europepmc.org/articles/PMC5790436/
Publikováno v:
Nucleic Acids Research
Antisense oligonucleotides (ASOs) are synthetic oligonucleotides that alter expression of disease-associated transcripts via Watson–Crick hybridization. ASOs that function through RNase H or the RNA-induced silencing complex (RISC) result in enzyma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cf29c0115be7f7f60b308ac2312a09
https://doi.org/10.1093/nar/gku184
https://doi.org/10.1093/nar/gku184
Autor:
Rebecca L. Miller, Sarah L. DeVos, Seung J. Chun, Carey S. Kebodeaux, Frank Rigo, Timothy M. Miller, Michaela Norrbom, Hana N. Dawson, C. Frank Bennett, Kathleen M. Schoch
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::880f2a8e4e4faf725a2ba339ae2a09f8
https://doi.org/10.1016/j.jalz.2015.07.256
https://doi.org/10.1016/j.jalz.2015.07.256
Autor:
Christian J. Leumann, Damian Ittig, Michaela Norrbom, Sue Murray, Thazha P. Prakash, Erich Koller, Andres Berdeja, Punit P. Seth, Alfred Chappell, Eric E. Swayze
Publikováno v:
Murray, Sue; Ittig, Damian; Koller, Erich; Berdeja, Andres; Chappell, Alfred; Prakash, Thazha P.; Norrbom, Michaela; Swayze, Eric E.; Leumann, Christian J.; Seth, Punit P. (2012). TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues-a comparative study of oligonucleotide length, design and chemistry. Nucleic acids research, 40(13), pp. 6135-6143. London: Oxford University Press 10.1093/nar/gks273
Nucleic Acids Research
Nucleic Acids Research
We report the evaluation of 20-, 18-, 16- and 14-mer phosphorothioate (PS)-modified tricycloDNA (tcDNA) gapmer antisense oligonucleotides (ASOs) in T(m), cell culture and animal experiments and compare them to their gap-matched 20-mer 2'-O-methoxyeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c92c0d56c63c1061e54f365f9315968
https://boris.unibe.ch/15321/1/6135.full-text-lowres.pdf
https://boris.unibe.ch/15321/1/6135.full-text-lowres.pdf