Hyphal Als proteins act as CR3 ligands to promote immune responses against Candida albicans

Autor: Tingting Zhou, Norma V. Solis, Michaela Marshall, Qing Yao, Rachel Garleb, Mengli Yang, Eric Pearlman, Scott G. Filler, Haoping Liu

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Patients with decreased levels of CD18 (β2 integrins) suffer from life-threatening bacterial and fungal infections. CD11b, the α subunit of integrin CR3 (CD11b/CD18, αMβ2), is essential for mice to fight against systemic Candida albicans

Externí odkaz: https://doaj.org/article/0f81f176012742c69ace6098249d696b

β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles

Autor: Bridget Ratitong, Michaela Marshall, Eric Pearlman

Publikováno v: Cell Reports, Vol 35, Iss 7, Pp 109139- (2021)

Summary: Neutrophils are an important source of interleukin (IL)-1β and other cytokines because they are recruited to sites of infection and inflammation in high numbers. Although secretion of processed, bioactive IL-1β by neutrophils is dependent

Externí odkaz: https://doaj.org/article/fadd67ab638c4a67bc64d7359e3f74a3

The role of IL-1a during early-stage Pseudomonas aeruginosa infection of the corneas

Autor: Bridget Ratitong, Michaela Marshall, Morgan Dragan, Charissa Anunciado, Eric Pearlman

Publikováno v: The Journal of Immunology. 208:50.41-50.41

Pseudomonas aeruginosa is an important cause of dermal, pulmonary and ocular disease. Our studies have focused on P. aeruginosa infections of the cornea as a major cause of blinding microbial infections. The infection leads to an influx of innate imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e60ad48bb118dc5390da9233afa2349
https://doi.org/10.4049/jimmunol.208.supp.50.41

Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil-derived acidic mammalian chitinase

Autor: Patricia R. Taylor, Anne Beauvais, William Carrera, Eric Pearlman, Steven de Jesus Carrion, Sixto M. Leal, Yan Sun, Brittany A. Armstrong, Heather L. Clark, Serena Abbondante, Isabelle Mouyna, Michaela E. Marshall, Jean-Paul Latgé

Publikováno v: European Journal of Immunology
European Journal of Immunology, 2019, 49 (6), pp.918-927. ⟨10.1002/eji.201847851⟩
European Journal of Immunology, Wiley-VCH Verlag, 2019, 49 (6), pp.918-927. ⟨10.1002/eji.201847851⟩
European journal of immunology, vol 49, iss 6

International audience; Aspergillus fumigatus is an important cause of pulmonary and systemic infections in immune compromised individuals, and of corneal ulcers and blindness in immune competent patients. To examine the role of chitin synthases in A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9972810202a7820fbfe3dc39c1db2ef0
https://hal.science/hal-02545853/document