Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michaela Lynott"'
Autor:
Maria A. Missinato, Sean Murphy, Michaela Lynott, Michael S. Yu, Anaïs Kervadec, Yu-Ling Chang, Suraj Kannan, Mafalda Loreti, Christopher Lee, Prashila Amatya, Hiroshi Tanaka, Chun-Teng Huang, Pier Lorenzo Puri, Chulan Kwon, Peter D. Adams, Li Qian, Alessandra Sacco, Peter Andersen, Alexandre R. Colas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Transdifferentiation has been proposed as an approach for regenerative medicine, but the mechanisms that safeguard cell identity are not well established. Here they identify transcription factors that oppose transdifferentiation and show that knockdo
Externí odkaz:
https://doaj.org/article/20fe073154364337abcffbba8fef58fe
Autor:
Suraj Kannan, Matthew Miyamoto, Renjun Zhu, Michaela Lynott, Jason Guo, Elaine Zhelan Chen, Alexandre R. Colas, Brian Leei Lin, Chulan Kwon
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112330- (2023)
Summary: A limitation in the application of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) is the failure of these cells to achieve full functional maturity. The mechanisms by which directed differentiation differs from endogenous development
Externí odkaz:
https://doaj.org/article/d92eadf8c9ae407a8716be839d22c04c
Autor:
Saswati Saha, Lionel Spinelli, Jaime A Castro Mondragon, Anaïs Kervadec, Michaela Lynott, Laurent Kremmer, Laurence Roder, Sallouha Krifa, Magali Torres, Christine Brun, Georg Vogler, Rolf Bodmer, Alexandre R Colas, Karen Ocorr, Laurent Perrin
Publikováno v:
eLife, Vol 11 (2022)
Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. We investigated the natural variation of cardiac performance in the sequenced inbred lines of the Drosophi
Externí odkaz:
https://doaj.org/article/35f1c5c43e764e80af9403e2933094a5
Autor:
Analyne M Schroeder, Tanja Nielsen, Michaela Lynott, Georg Vogler, Alexandre R Colas, Rolf Bodmer
Publikováno v:
PLoS Genetics, Vol 18, Iss 10, p e1010448 (2022)
Establishing a catalog of Congenital Heart Disease (CHD) genes and identifying functional networks would improve our understanding of its oligogenic underpinnings. Our studies identified protein biogenesis cofactors Nascent polypeptide-Associated Com
Externí odkaz:
https://doaj.org/article/d1dece93db3b499cad8f2aa82f483b61
Autor:
Lionel Spinelli, Saswati Saha, Jaime A Castro Mondragon, Anaïs Kervadec, Michaela Lynott, Laurent Kremmer, Laurence Roder, Sallouha Krifa, Magali Torres, Christine Brun, Georg Vogler, Rolf Bodmer, Alexandre R Colas, Karen Ocorr, Laurent Perrin
Publikováno v:
eLife
eLife, 2022, 11, ⟨10.7554/eLife.82459⟩
eLife, 2022, 11, ⟨10.7554/eLife.82459⟩
Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. We investigated the natural variation of cardiac performance in the sequenced inbred lines of the Drosophi
Autor:
Lionel Spinelli, Saswati Saha, Jaime A Castro Mondragon, Anaïs Kervadec, Michaela Lynott, Laurent Kremmer, Laurence Roder, Sallouha Krifa, Magali Torres, Christine Brun, Georg Vogler, Rolf Bodmer, Alexandre R Colas, Karen Ocorr, Laurent Perrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd2f526e9147dbf803d2e720ef3bc8ec
https://doi.org/10.7554/elife.82459.sa2
https://doi.org/10.7554/elife.82459.sa2
Autor:
Tanja Nielsen, Anaïs Kervadec, Maria A. Missinato, Michaela Lynott, Xin-Xin I. Zeng, Marie Berenguer, Stanley M. Walls, Analyne Schroeder, Katja Birker, Greg Duester, Paul Grossfeld, Timothy J. Nelson, Timothy M. Olson, Karen Ocorr, Rolf Bodmer, Jeanne L. Theis, Georg Vogler, Alexandre R. Colas
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD). The pathogenesis of HLHS is poorly understood and due to the likely oligogenic complexity of the disease, definitive HLHS-causing genes have not yet been identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d332e5aa3bd31779e9bf74cf83b82f
https://doi.org/10.1101/2022.07.01.22277112
https://doi.org/10.1101/2022.07.01.22277112
Autor:
Peter Andersen, Li Qian, Maria A. Missinato, Sean Murphy, Prashila Amatya, Christopher Lee, Alessandra Sacco, Michaela Lynott, Suraj Kannan, Alexandre R. Colas, Peter D. Adams, Pier Lorenzo Puri, Chun-Teng Huang, Anaïs Kervadec, Chulan Kwon, Hiroshi Tanaka, Michael S. Yu, Yu-Ling Chang, Mafalda Loreti
The comprehensive characterization of mechanisms safeguarding cell fate identity in differentiated cells is crucial for 1) our understanding of how differentiation is maintained in healthy tissues or misregulated in disease states and 2) to improve o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0953cb35f0c4219e6b07b959021186bb
https://doi.org/10.1101/2021.06.28.450261
https://doi.org/10.1101/2021.06.28.450261
Publikováno v:
The FASEB Journal. 30