NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

Autor: Michaela Kerstin Müller, Eric Jacobi, Kenji Sakimura, Roberto Malinow, Jakob von Engelhardt

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-20 (2018)

Abstract Amyloid beta (Aβ)-mediated synapse dysfunction and spine loss are considered to be early events in Alzheimer’s disease (AD) pathogenesis. N-methyl-D-aspartate receptors (NMDARs) have previously been suggested to play a role for Amyloid be

Externí odkaz: https://doaj.org/article/ca16cadee91547678309f047b42f3ecb

Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

Autor: Maria Pardo-Navarro, Ulrich Pfisterer, Michaela Kerstin Müller, Susmita Malwade, Karin Sørig Hougaard, Konstantin Khodosevich, Jakob von Engelhardt, Janina Gasthaus, Navneet A. Vasistha, Dilys Weijers, Irina Korshunova, Diego García-González

Publikováno v: Vasistha, N A, Pardo-Navarro, M, Gasthaus, J, Weijers, D, Müller, M K, García-González, D, Malwade, S, Korshunova, I, Pfisterer, U, von Engelhardt, J, Hougaard, K S & Khodosevich, K 2020, ' Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner ', Molecular Psychiatry, vol. 25, pp. 2313-2329 . https://doi.org/10.1038/s41380-019-0539-5
Molecular Psychiatry

Severe infections during pregnancy are one of the major risk factors for cognitive impairment in the offspring. It has been suggested that maternal inflammation leads to dysfunction of cortical GABAergic interneurons that in turn underlies cognitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e3953df29269d7b8d108ee066b6ab8
https://curis.ku.dk/portal/da/publications/maternal-inflammation-has-a-profound-effect-on-cortical-interneuron-development-in-a-stage-and-subtypespecific-manner(bdab8550-a01d-4c6c-bea5-4bb90ccad77e).html

Age-dependent degeneration of mature dentate gyrus granule cells following NMDA receptor ablation

Autor: Yasuhito Watanabe, Michaela Kerstin Müller, Jakob von Engelhardt, Rolf Sprengel, Hannah Monyer, Peter H. Seeburg

Publikováno v: Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 8 (2016)
Frontiers in molecular neuroscience 8, 87 (2016). doi:10.3389/fnmol.2015.00087

N-methyl-D-aspartate receptors (NMDARs) in all hippocampal areas play an essential role in distinct processes of memory formation as well as in sustaining cell survival of postnatally generated neurons in the dentate gyrus (DG). In contrast to the be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985557e2611e8d7e3fa82c514c8186e5
https://www.ncbi.nlm.nih.gov/pubmed/26793056