Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michaela K. Marschütz"'
Publikováno v:
International Journal of Pharmaceutics. 274:97-105
This study examined the influence of the pH on the mucoadhesive and cohesive properties of polyarcylic acid (PAA) and thiolated PAA. The pH of PAA (molecular mass: 450 kDa) and of a corresponding PAA-cysteine conjugate was adjusted to 3, 4, 5, 6, 7 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4609755e7606c85e1ede85844ca8cf2
https://doi.org/10.1016/j.ijpharm.2003.06.001
https://doi.org/10.1016/j.ijpharm.2003.06.001
Publikováno v:
Journal of Pharmacy and Pharmacology. 54:603-610
The purpose of this study was to evaluate the inhibitory effect of thiolated carbopol 974P (carbcys) on the enzymatic activity of vaginal aminopeptidase N in-vitro. Mediated by a carbodiimide, L-cysteine was covalently linked to carbopol 974P. Depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8349f2c04a6693b5729e17c974705c5
https://doi.org/10.1211/0022357021778907
https://doi.org/10.1211/0022357021778907
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 52:137-144
Within the present study various polycarbophil (PCP)-serine protease inhibitor conjugates were synthesized and the influence of different spacers on their inhibitory efficacy was evaluated in vitro. Results demonstrated that 4.2+/-0.15 units (n=3; +/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69658b7e215e55511045ecaa44361ff
https://doi.org/10.1016/s0939-6411(01)00175-8
https://doi.org/10.1016/s0939-6411(01)00175-8
Publikováno v:
Biomaterials. 21:1499-1507
A drug-carrier matrix has been developed which protects embedded insulin from degradation by the luminally secreted serine-proteases trypsin (EC 3.4.21.4), chymotrypsin (EC 3.4.21.1) and elastase (EC 3.4.21.36) in vitro. Increasing amounts of the Bow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54e965e6c57331daf655776ac3b8988
https://doi.org/10.1016/s0142-9612(00)00039-9
https://doi.org/10.1016/s0142-9612(00)00039-9
Publikováno v:
Pharmaceutical Research. 17:1468-1474
Purpose. To develop an oral controlled release system for insulin. Methods. The polymer-inhibitor conjugates carboxymethylcellulose (CMC)-Bowman-Birk inhibitor and CMC-elastatinal were homo- genized with polycarbophil-cysteine conjugate, insulin, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c6d19416da159a0cf6b52e6ae5ecef8
https://doi.org/10.1023/a:1007696723125
https://doi.org/10.1023/a:1007696723125
Publikováno v:
Pharmaceutical Research. 14:181-185
Purpose. Develop and evaluate systems to prevent aminopeptidase N caused enzymatic degradation of perorally administrated peptide drugs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a41fc83823778061bce9d9a72ffd74a8
https://doi.org/10.1023/a:1012096510125
https://doi.org/10.1023/a:1012096510125
Autor:
Hans Schuhbauer, Michaela K. Marschütz, Andreas Bernkop-Schnürch, Elisabeth Reich‐Rohrwig, Martin Kratzel
Publikováno v:
Drug development and industrial pharmacy. 30(1)
Within this study an oral sustained release dosage form of alpha-lipoic acid (thioctic acid) has been generated and evaluated in healthy volunteers. A granulate comprising 56.8% alpha-lipoic acid and 43.2% chitosan acetate was compressed to tablets (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5ea4d31d723c6e987c713ced72c1d3
https://pubmed.ncbi.nlm.nih.gov/15000428
https://pubmed.ncbi.nlm.nih.gov/15000428
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 18(1)
The objective of this study was to evaluate the influence of the molecular mass and accordingly the polymer chain length on mucoadhesion and cohesion of thiolated polymers. Linear poly(acrylic acid)-cysteine (PAA-Cys) conjugates of 2-, 45-, 250- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55c4a5c87d908063feb721802023554
https://pubmed.ncbi.nlm.nih.gov/12554077
https://pubmed.ncbi.nlm.nih.gov/12554077
Publikováno v:
Peptides. 23(10)
Oral administration of peptide antigens, to provide proper mucosal and/or systemic immunity, is largely ineffective. This is mainly due to the very small quantity of antigen that survives degradation in the intestine and that crosses the intestinal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c75084b11c6162663e96805e92b0e40
https://pubmed.ncbi.nlm.nih.gov/12383859
https://pubmed.ncbi.nlm.nih.gov/12383859