Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Michaela J Higgins"'
Publikováno v:
Current Problems in Cancer: Case Reports, Vol 9, Iss , Pp 100219- (2023)
Introduction: PIK3CA mutations occur in approximately 40% of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancers, and confer a worse prognosis and inferior response to endocrine therapy. Alpelisib i
Externí odkaz:
https://doaj.org/article/5133bfd36bcd48ffb7c9140be119b203
Autor:
Lisa Prior, Hannah Featherstone, David O’Reilly, Killian Nugent, Marvin Lim, John McCaffrey, Michaela J Higgins, Catherine M. Kelly
Publikováno v:
Cardio-Oncology, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Background Due to advances in care, most women diagnosed with breast cancer do not die from the disease itself. Instead, cardiovascular disease (CVD) remains the most frequent cause of death. Many breast cancer patients are older and have es
Externí odkaz:
https://doaj.org/article/9e8b320586f647c98c4f41c4871d326d
Autor:
Timothy K Cronin, Cian Ronayne, Niamh O’Donovan, Eimear McGuinness, Katie Cooke, Maeve Dennehy, Colum Dennehy, Derek G Power, Mary R Cahill, Dearbhaile C Collins, Roisin M Connolly, Richard M Bambury, Vitaliy Mykytiv, Michaela J Higgins, Sinéad A Noonan, Seamus O'Reilly
Purpose Expanded access programs (EAPs) allow patients with cancer who have unmet clinical needs to obtain access to pre-authorisation treatments. There is no standardised process or registry for implementing these programs nationally and real world
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bbd241c7778f67eabe9a8f0ff88e312
https://doi.org/10.21203/rs.3.rs-2790434/v1
https://doi.org/10.21203/rs.3.rs-2790434/v1
Autor:
Ben Ho Park, Antonio C. Wolff, Pedram Argani, Ashley Cimino-Mathews, Leslie Cope, Dianna Maar, Michael L. Samuels, Stacie Jeter, Jill Kessler, Dustin A. VanDenBerg, Josh Lauring, Paula J. Hurley, Julie Lange, Mehran Habibi, Lisa Jacobs, Vered Stearns, Michaela J. Higgins, Timothy Burns, David Chu, Brian G. Blair, Justin Cidado, Patricia Valda Toro, Hong Yuen Wong, Daniel J. Zabransky, Sarah Croessmann, Rory L. Cochran, Sasidharan Balukrishna, Danijela Jelovac, Julia A. Beaver
PDF file - 395KB, Figure S1. Pre-surgery plasma ddPCR analysis for PIK3CA mutations. Figure S2. Positive and negative controls for droplet thresholds and counts. Figure S3. Lower Limit of Detection for PIK3CA Exon 9. Supplementary Table S1: Primers u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b88ec1788ebceb33dc2a7e31c947899
https://doi.org/10.1158/1078-0432.22449798
https://doi.org/10.1158/1078-0432.22449798
Autor:
Ben Ho Park, Antonio C. Wolff, Pedram Argani, Ashley Cimino-Mathews, Leslie Cope, Dianna Maar, Michael L. Samuels, Stacie Jeter, Jill Kessler, Dustin A. VanDenBerg, Josh Lauring, Paula J. Hurley, Julie Lange, Mehran Habibi, Lisa Jacobs, Vered Stearns, Michaela J. Higgins, Timothy Burns, David Chu, Brian G. Blair, Justin Cidado, Patricia Valda Toro, Hong Yuen Wong, Daniel J. Zabransky, Sarah Croessmann, Rory L. Cochran, Sasidharan Balukrishna, Danijela Jelovac, Julia A. Beaver
Purpose: Detecting circulating plasma tumor DNA (ptDNA) in patients with early-stage cancer has the potential to change how oncologists recommend systemic therapies for solid tumors after surgery. Droplet digital polymerase chain reaction (ddPCR) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07557c69ad2cac686a1d97cf5f134f96
https://doi.org/10.1158/1078-0432.c.6521754
https://doi.org/10.1158/1078-0432.c.6521754
Autor:
Ben Ho Park, Josh Lauring, Pedram Argani, Yoshitaka Hosokawa, Akinobu Ota, Yuko Konishi, Sivasundaram Karnan, Rory L. Cochran, Sarah Croessmann, Danijela Jelovac, Justin Cidado, Michaela J. Higgins, Morassa Mohseni, Joseph P. Garay, William Matsui, Zeshaan Rasheed, Samuel Ray Denmeade, D. Marc Rosen, John P. Gustin, Abde M. Abukhdeir, Brian G. Blair, Hiroyuki Konishi, Hong Yuen Wong, Grace M. Wang
PDF file - 1480K, Figure S1. Double knock in clones have single mutant PIK3CA alleles and equivalent expression of mutant and wild type PIK3CA and form aberrant structures in 3D culture. Figure S2. DKI xenografts retain the same number of KRAS and PI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbb464b436aa1e0e0399e735863603e
https://doi.org/10.1158/0008-5472.22397007
https://doi.org/10.1158/0008-5472.22397007
Autor:
Jane E. Brock, Michelle Demeo, Dan G. Duda, Mei Rosa Ng, Elena Ivanova, Sara M. Tolaney, David R. Ziehr, William T. Barry, Steven J. Isakoff, Beth Overmoyer, Hao Guo, Eric P. Winer, Cloud P. Paweletz, Nikhil H. Ramaiya, Rakesh K. Jain, Michaela J. Higgins
Publikováno v:
The Oncologist
Oncologist
Oncologist
This study evaluates the safety, efficacy, and biomarkers of response to cabozantinib, a multikinase inhibitor, in patients with metastatic triple‐negative breast cancer (mTNBC). Cabozantinib showed encouraging safety and efficacy signals but did n
Autor:
Paula D. Ryan, Ann H. Partridge, Jackie Szymonifka, Michaela J. Higgins, Yanin Chavarri-Guerra, Steven E. Come, P Liedke, Dianne M. Finkelstein, Tessa Cigler, Paul E. Goss, Jennifer A. Ligibel
Publikováno v:
British Journal of Cancer
Background: Acquiring resistance to endocrine therapy is common in metastatic hormone-receptor-positive breast cancer (MBC). These patients most often transition either to next-line endocrine therapy or to systemic chemotherapy. However, withdrawal o
Autor:
Michaela J. Higgins, Justin Cidado, Michael L. Samuels, Daniel J. Zabransky, Paula J. Hurley, Leslie Cope, Hong Yuen Wong, Sasidharan Balukrishna, Patricia Valda Toro, Dustin A. VanDenBerg, Sarah Croessmann, Julie R. Lange, Stacie Jeter, Mehran Habibi, David Chu, Timothy F. Burns, Rory L. Cochran, Danijela Jelovac, Josh Lauring, Pedram Argani, Ashley Cimino-Mathews, Julia A. Beaver, Antonio C. Wolff, Vered Stearns, Jill Kessler, Dianna Maar, Lisa K. Jacobs, Ben Ho Park, Brian G. Blair
Publikováno v:
Clinical Cancer Research. 20:2643-2650
Purpose: Detecting circulating plasma tumor DNA (ptDNA) in patients with early-stage cancer has the potential to change how oncologists recommend systemic therapies for solid tumors after surgery. Droplet digital polymerase chain reaction (ddPCR) is
Publikováno v:
Current Breast Cancer Reports. 6:146-153
Circulating Tumor cells (CTCs) represent tumor cells in the blood stream dislodged from the primary tumor. The presence of CTCs in the bloodstream provides a unique opportunity to sample cancer tissue by means of a relatively less-invasive “liquid