Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties

Autor: Marek Nečas, Michaela Fojtu, Jindriska Leischner Fialova, Martin Sojka, Michal Masarik, Radek Marek

Publikováno v: Inorganic Chemistry. 58:10861-10870

We report here the first coupling of Ru(II) units with cucurbit[6/7]uril-based pseudorotaxane ligands meant for biological application. The resulting ruthenium-capped rotaxanes were fully characterized, and a structure of one supramolecular system wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d96950fdee8ff5a6198e1d9ec0807472
https://doi.org/10.1021/acs.inorgchem.9b01203

Reduction of Doxorubicin-Induced Cardiotoxicity Using Nanocarriers: A Review

Autor: Marie Nováková, Marketa Vaculovicova, Vojtech Adam, Anna Skotakova, Jaromír Gumulec, Michaela Fojtu, Martina Raudenská, Petr Babula, Tibor Stračina, Michal Masarik

Publikováno v: Current Drug Metabolism. 18:237-263

Background: Anthracycline antibiotic doxorubicin (DOX) is a very potent and extensively prescribed chemotherapeutic drug. It is widely utilized in the therapy of variety of haematological and solid tumours, although its administration is commonly acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119d8b9b1acb34b9428a970b143dbec9
https://doi.org/10.2174/1389200218666170105165444

Unexpected therapeutic effects of cisplatin

Autor: Michaela Fojtu, Jaromír Gumulec, Jan Balvan, Martina Raudenská, Michal Masarik

Publikováno v: Metallomics : integrated biometal science. 11(7)

Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4983a3e1992275b84e698eb496e5ca5c
https://pubmed.ncbi.nlm.nih.gov/31098602

Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC

Autor: Hana Binková, Jan Balvan, Jaromír Gumulec, Rom Kostrica, Martina Raudenská, Vojtech Adam, Michal Masarik, Michaela Fojtu, Hana Polanska, Zbynek Heger, René Kizek, Zuzana Horáková, Markéta Svobodová

Publikováno v: Tumor Biology. 37:7193-7201

Approximately 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and the overall 5-year survival rate is not higher than 50 %. There is much evidence that human papillomavirus (HPV) infection may influence the expression of commonly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5452383eccb396a45011f57ae33f3f
https://doi.org/10.1007/s13277-015-4569-6

Modulation of Induced Cytotoxicity of Doxorubicin by Using Apoferritin and Liposomal Cages

Autor: Pavel Kopel, Lukas Nejdl, Lucia Knopfová, Markéta Sztalmachová, Martina Raudenská, Marie Stiborová, Michal Masarik, Jana Vlachova, René Kizek, Michaela Fojtu, Vojtech Adam, Petr Babula, Anna Skotakova, Sylvie Skalickova, Jaromír Gumulec

Publikováno v: International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 22960-22977 (2014)
International Journal of Molecular Sciences. 2014, vol. 15, issue 12, p. 22960-22977.
International Journal of Molecular Sciences
Volume 15
Issue 12
Pages 22960-22977

Doxorubicin is an effective chemotherapeutic drug, however, its toxicity is a significant limitation in therapy. Encapsulation of doxorubicin inside liposomes or ferritin cages decreases cardiotoxicity while maintaining anticancer potency. We synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8753f82b380068e0e53ea78a6c65a94a
https://doi.org/10.3390/ijms151222960