3D printed microfluidic modules: passive mixers and cells encapsulation in alginate

Autor: Federico Dalcanale, Michaela Caj, Felix Schuler, Kireedan Ganeshanathan, Laura Suter-Dick

Publikováno v: Current Directions in Biomedical Engineering. 8:27-29

passive mixers and droplet generation microfluidic chip modules were designed and manufactured using a commercial SLA 3D-printer. The mixing modules were designed specifically for 3D-printing and evaluated using FEM modeling. The co-flow droplet gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0c126199524a214691fafc9a4171852
https://doi.org/10.1515/cdbme-2022-1008

Single Cell Gene Expression Analysis in a 3D Microtissue Liver Model Reveals Cell Type-Specific Responses to Pro-Fibrotic TGF-β1 Stimulation

Autor: Laura Suter-Dick, Gaia Titolo, Enkelejda Miho, Michaela Caj, Lmar Babrak, Catherine Jane Messner

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4372, p 4372 (2021)

3D cell culture systems are widely used to study disease mechanisms and therapeutic interventions. Multicellular liver microtissues (MTs) comprising HepaRG, hTERT-HSC and THP-1 maintain multicellular interactions and physiological properties required

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97532d21772edf72d51bd2814469beb8
https://pubmed.ncbi.nlm.nih.gov/33922101

Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells

Autor: Eva Hartlieb, Katharina Leucht, Gerhard Liebisch, Martin Hausmann, Hans-Ulrich Humpf, Anne Fischbeck, Gerhard Rogler, Petr Beneš, Michael Fried, Michaela Caj

Scope The major alimentary sources for the plasma membrane lipid sphingomyelin (SM) are dairy products, eggs, and meat. We recently reported that the SM metabolite ceramide induces cathepsin D mediated apoptosis in murine intestinal epithelial cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f069e151cd822f40d11bc166a38f276
https://doi.org/10.5167/uzh-92825

Burrowing is a sensitive behavioural assay for monitoring general wellbeing during dextran sulfate sodium colitis in laboratory mice

Autor: Katharina Leucht, Nikola Cesarovic, Flora Nicholls, Gerhard Rogler, Margarete Arras, Michaela Caj, Martin Hausmann, Paulin Jirkof

Publikováno v: Laboratory animals. 47(4)

An impaired intestinal epithelial barrier is thought to be a major factor in the pathogenesis of human inflammatory bowel disease (IBD). IBD is frequently investigated by inducing a damaged barrier in murine models of colitis. This can be done by fee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd623e184273b8d16f56a7fafb2db4af
https://pubmed.ncbi.nlm.nih.gov/23828853

Mo1701 MYD88 Signaling Is Not Essential in Intestinal Fibrosis in Mice

Autor: Martin Hausmann, Gerhard Rogler, Michaela Caj, Michael Fried, Christian Lutz

Publikováno v: Gastroenterology. 146:S-639

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f66ae8b204f5367d1a1d7c91b45441d
https://doi.org/10.1016/s0016-5085(14)62318-0