Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Michaela C. Baldauf"'
Autor:
Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M. L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L. B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino, Thomas G. P. Grünewald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Ewing sarcoma is characterized by the fusion of EWSR1 and FLI1. Here, the authors show that EWSR1-FLI1 increases the activity of the developmental transcription factor SOX6, which promotes tumor growth but also increases sensitivity to oxidative stre
Externí odkaz:
https://doaj.org/article/6dc51a99a4e44ac186061ab97fa34c62
Autor:
Julian Musa, Florencia Cidre-Aranaz, Marie-Ming Aynaud, Martin F. Orth, Maximilian M. L. Knott, Olivier Mirabeau, Gal Mazor, Mor Varon, Tilman L. B. Hölting, Sandrine Grossetête, Moritz Gartlgruber, Didier Surdez, Julia S. Gerke, Shunya Ohmura, Aruna Marchetto, Marlene Dallmayer, Michaela C. Baldauf, Stefanie Stein, Giuseppina Sannino, Jing Li, Laura Romero-Pérez, Frank Westermann, Wolfgang Hartmann, Uta Dirksen, Melissa Gymrek, Nathaniel D. Anderson, Adam Shlien, Barak Rotblat, Thomas Kirchner, Olivier Delattre, Thomas G. P. Grünewald
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Interactions between germline variants and somatic mutations is a relatively unexplored topic in cancer. Here, in Ewing sarcoma, the authors show that binding of the oncogenic EWSR1-FLI1 fusion transcription factor to a polymorphic enhancer-like DNA
Externí odkaz:
https://doaj.org/article/b15283577e6941feafb9a8d8c4019ddd
Autor:
Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M. L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L. B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino, Thomas G. P. Grünewald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20017-2
Externí odkaz:
https://doaj.org/article/695c85c77f7b474cb476de9a68f5c58f
Autor:
Michaela C. Baldauf, Julia S. Gerke, Andreas Kirschner, Franziska Blaeschke, Manuel Effenberger, Kilian Schober, Rebeca Alba Rubio, Takayuki Kanaseki, Merve M. Kiran, Marlene Dallmayer, Julian Musa, Nurset Akpolat, Ayse N. Akatli, Fernando C. Rosman, Özlem Özen, Shintaro Sugita, Tadashi Hasegawa, Haruhiko Sugimura, Daniel Baumhoer, Maximilian M. L. Knott, Giuseppina Sannino, Aruna Marchetto, Jing Li, Dirk H. Busch, Tobias Feuchtinger, Shunya Ohmura, Martin F. Orth, Uwe Thiel, Thomas Kirchner, Thomas G. P. Grünewald
Publikováno v:
OncoImmunology, Vol 7, Iss 9 (2018)
Immunotherapy can revolutionize anti-cancer therapy if specific targets are available. Immunogenic peptides encoded by cancer-specific genes (CSGs) may enable targeted immunotherapy, even of oligo-mutated cancers, which lack neo-antigens generated by
Externí odkaz:
https://doaj.org/article/fe2207c4008c460db2d92b4dc1887c16
Autor:
Sandrine Grossetête, Laura Romero-Pérez, Jing Li, Nathaniel D. Anderson, Maximilian M. L. Knott, Gal Mazor, Didier Surdez, Florencia Cidre-Aranaz, Adam Shlien, Thomas Kirchner, Marie-Ming Aynaud, Uta Dirksen, Stefanie Stein, Shunya Ohmura, Mor Varon, Wolfgang Hartmann, Thomas G. P. Grunewald, Moritz Gartlgruber, Julian Musa, Giuseppina Sannino, Marlene Dallmayer, Julia S. Gerke, Olivier Delattre, Aruna Marchetto, Michaela C. Baldauf, Frank Westermann, Martin F. Orth, Tilman L B Hölting, Olivier Mirabeau, Barak Rotblat, Melissa Gymrek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic alterations except for pathognomonic driver-mutations that cannot explain overt variations in clinical outcome. Here, we demonstrate in EwS how cooperation of dominant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbd4e83469d0eb710d62dcc96f0cd36
http://link.springer.com/article/10.1038/s41467-019-12071-2
http://link.springer.com/article/10.1038/s41467-019-12071-2
Autor:
Florencia Cidre-Aranaz, Rebeca Alba-Rubio, Laura Romero-Pérez, Shunya Ohmura, Julia S. Gerke, Thomas Knösel, Annelore Altendorf-Hofmann, Michaela C. Baldauf, Giuseppina Sannino, Marlene Dallmayer, Thomas Dandekar, Michiyuki Hakozaki, Julian Musa, Stefanie Stein, Thomas G. P. Grunewald, Thomas Kirchner, Jing Li, Aruna Marchetto, Maximilian M. L. Knott, Martin F. Orth, Tilman L B Hölting, Elke Butt, Fabienne S. Wehweck
Publikováno v:
International Journal of Cancer. 144:859-867
Soft-tissue sarcomas are rare, heterogeneous, and often aggressive mesenchymal cancers. Many of them are associated with poor outcome, partially because biomarkers that can identify high-risk patients are lacking. Studies on sarcomas are often limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d706a9bb649eeb542eb73a6f06b9e82
https://doi.org/10.1002/ijc.31903
https://doi.org/10.1002/ijc.31903
Autor:
Anton G. Henssen, Laura Romero-Pérez, Chiara Arrigoni, Shunya Ohmura, Giuseppina Sannino, Marlene Dallmayer, David Saucier, Martin F. Orth, Florencia Cidre-Aranaz, Thomas G. P. Grunewald, Maximilian M. L. Knott, James F. Amatruda, Tilman L B Hölting, Julian Musa, Fabienne S. Wehweck, Stefanie Stein, Thomas Kirchner, Michaela C. Baldauf, Maria Vittoria Colombo, Aruna Marchetto, Victor Bardinet, Julia S. Gerke, Jing Li, Andrea Cossarizza, Matteo Moretti
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic progenitors. It is characterized by fusion oncoproteins involving EWSR1 and variable members of the ETS-family of transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d192e82eef520d9e933505a5b9e9189
https://doi.org/10.1038/s41467-020-20017-2
https://doi.org/10.1038/s41467-020-20017-2
Autor:
Elmar Wolf, Rupert Öllinger, Jürgen Ruland, Gaurav Jain, Stefan Burdach, Gunther Richter, Andreas Petry, Michaela C. Baldauf, Uwe Thiel, Carolin Prexler, Poul H. Sorensen, Erik Hameister, Agnes Görlach, Julia Hofstetter, Maxim Barenboim, Thomas G. P. Grunewald, Juliane Schmäh, Busheng Xue, Davide G. Franchina, Rebeca Alba Rubio, Roland Rad, Gunnar Cario, Alexandra Sipol, Dirk Brenner
Cancer cells are in most instances characterized by rapid proliferation and uncontrolled cell division. Hence, they must adapt to proliferation-induced metabolic stress through intrinsic or acquired anti-metabolic stress responses to maintain homeost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c4b255135c95232678bc63527c94896
https://doi.org/10.1101/2020.11.01.363986
https://doi.org/10.1101/2020.11.01.363986
Autor:
Florencia Cidre-Aranaz, Thomas G. P. Grunewald, Chiara Arrigoni, Maximilian M. L. Knott, David Saucier, Shunya Ohmura, Fabienne S. Wehweck, Stefanie Stein, Maria Vittoria Colombo, Giuseppina Sannino, Marlene Dallmayer, Tilman L. B. Hoelting, Jing Li, Matteo Moretti, Julian Musa, Julia S. Gerke, Victor Bardinet, Laura Romero-Pérez, James F. Amatruda, Michaela C. Baldauf, Thomas Kirchner, Andrea Cossarizza, Aruna Marchetto, Martin F. Orth, Anton G. Henssen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic progenitors. It is characterized by fusion oncoproteins involving EWSR1 and variable members of the ETS-family of transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04198e75025cda3ff06be4494bf83ce4
https://doi.org/10.1038/s41467-020-16244-2
https://doi.org/10.1038/s41467-020-16244-2
Autor:
Didier Surdez, Tadashi Hasegawa, Maximilian M. L. Knott, Fabienne S. Wehweck, Anton G. Henssen, Shunya Ohmura, Florencia Cidre-Aranaz, Marlene Dallmayer, Uta Dirksen, Ozlem Ozen, Takayuki Kanaseki, Aruna Marchetto, Martin F. Orth, Tilman L B Hölting, Laura Romero-Pérez, Shintaro Sugita, Olivier Delattre, Michaela C. Baldauf, Thomas Kirchner, Wolfgang Hartmann, Thomas G. P. Grunewald, Merve Kasan, Julia S. Gerke, Jing Li, Tanja Paul, Stefanie Bertram, Julian Musa
Publikováno v:
Cancers
Volume 12
Issue 3
Cancers, Vol 12, Iss 3, p 644 (2020)
Volume 12
Issue 3
Cancers, Vol 12, Iss 3, p 644 (2020)
Ewing sarcoma (EwS) is an aggressive cancer displaying an undifferentiated small-round-cell histomorphology that can be easily confused with a broad spectrum of differential diagnoses. Using comparative transcriptomics and immunohistochemistry (IHC),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b804dc0d3d91f33efb0020cca25ad5a8