Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Michaela Aubele"'
Publikováno v:
Analytical Cellular Pathology, Vol 24, Iss 2-3, Pp 69-76 (2002)
The hypothetical multistep model of breast carcinogenesis suggests a transition from normal epithelium to invasive carcinoma via intraductal hyperplasia (without and with atypia) and in situcarcinoma. These presumptive precursor lesions are currently
Externí odkaz:
https://doaj.org/article/ae42d8c7c9e24615bbbaa500799739ca
Autor:
Michaela Aubele, Gert Auer, Herbert Braselmann, Jörg Nährig, Horst Zitzelsberger, Leticia Quintanilla‐Martinez, Jan Smida, Axel Walch, Heinz Höfler, Martin Werner
Publikováno v:
Analytical Cellular Pathology, Vol 24, Iss 2-3, Pp 77-87 (2002)
Multiple chromosomal imbalances have been identified in breast cancer using comparative genomic hybridization (CGH). Their association with the primary tumors' potential for building distant metastases is unknown. In this study we have investigated 3
Externí odkaz:
https://doaj.org/article/d1082ba0dd994a648424beb4dfb5eaca
Autor:
Michaela Aubele, Margaret Cummings, Axel Walch, Horst Zitzelsberger, Jörg Nährig, Heinz Höfler, Martin Werner
Publikováno v:
Analytical Cellular Pathology, Vol 20, Iss 1, Pp 17-24 (2000)
There is evidence that breast cancer is a heterogeneous disease phenotypically as well as molecular biologically. So far, heterogeneity on the molecular biological level has not been investigated in potential precursor lesions, such as ductal hyperpl
Externí odkaz:
https://doaj.org/article/1261106808e74083809da99885fde117
Autor:
Axel Walch, Karin Bink, Peter Gais, Stefan Stangl, Peter Hutzler, Michaela Aubele, James Mueller, Heinz Höfler, Martin Werner
Publikováno v:
Analytical Cellular Pathology, Vol 20, Iss 1, Pp 25-32 (2000)
Amplifiction of the Her-2/neu gene is accompanied by overexpression of its cell surface receptor product, c‐erbB‐2 protein. To investigate the degree of intratumoural heterogeneity we applied immunohistochemistry in primary Barrett’s adenocarci
Externí odkaz:
https://doaj.org/article/0493ec65ec0642efa047ca66b01af4f1
Publikováno v:
Analytical Cellular Pathology, Vol 15, Iss 1, Pp 19-29 (1997)
In molecular pathology numerical chromosome aberrations have been found to be decisive for the prognosis of malignancy in tumours. The existence of such aberrations can be detected by interphase fluorescence in situ hybridization (FISH). The gain or
Externí odkaz:
https://doaj.org/article/0b890ee766fa4b01a29ee32fe44486ce
Autor:
Wilko Weichert, Rudolf Napieralski, Axel Walch, Gert Auer, Viktor Magdolen, Jonathan Perkins, Gabriele Schricker, Olaf Wilhelm, Kurt Ulm, Marion Kiechle, Michaela Aubele, Moritz Hamann
Publikováno v:
Breast Care 16, 523-531 (2021)
Breast Care (Basel)
Breast Care (Basel)
Background: PITX2 DNA methylation has been shown to predict outcomes in high-risk breast cancer patients after anthracycline-based chemotherapy. To determine its prognostic versus predictive value, the impact of PITX2 DNA methylation on outcomes was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715d466c9b352e0a707870b55a58a646
https://doi.org/10.1159/000510468
https://doi.org/10.1159/000510468
Autor:
Gabriele Schricker, Michaela Aubele, Moritz Hamann, Olaf Wilhelm, Rudolf Napieralski, Stefan Paepke, Kurt Ulm, Jonathan Perkins, Gert Auer, Marion Kiechle
Publikováno v:
Cancer Research. 80:P3-08
Background: Published data on the basis of a research-use-only PITX2 methylation assay using fresh-frozen tissue showed that the PITX2 DNA methylation may be a predictive marker for response to (neo) adjuvant anthracycline-based chemotherapy in breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f087b87a39a47b631bc7608b2829ba3f
https://doi.org/10.1158/1538-7445.sabcs19-p3-08-65
https://doi.org/10.1158/1538-7445.sabcs19-p3-08-65
Autor:
Xiaocong, Geng, Lamiya, Babayeva, Axel, Walch, Michaela, Aubele, Eva, Groß, Marion, Kiechle, Holger, Bronger, Tobias, Dreyer, Viktor, Magdolen, Julia, Dorn
Publikováno v:
Am J Cancer Res
In normal physiology, kallikrein-related peptidase 7 (KLK7), together with other members of the kallikrein-related peptidase family, is mainly involved in skin desquamation and keratinization processes. Moreover, expression of KLK7 was shown in vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f33378be64636875cf2d298bb58fec97
https://europepmc.org/articles/PMC7339269/
https://europepmc.org/articles/PMC7339269/
Autor:
Michaela Aubele, Gabriele Schricker, Manfred Schmitt, Christoph Thomssen, Martina Vetter, Jonathan Perkins, Jürgen Lauber, John W.M. Martens, Olaf Wilhelm, Kurt Ulm, Aurelia Noske, Marion Kiechle, Rudolph Napieralski, Wilko Weichert
Publikováno v:
Breast Care, 13(6), 425-433. Karger
Background: Breast cancer patients at high risk for recurrence are treated with anthracycline-based chemotherapy, but not all patients do equally benefit from such a regimen. To further improve therapy decision-making, biomarkers predicting outcome a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccee2a355a317cb622754b5d377372d9
https://doi.org/10.1159/000493016
https://doi.org/10.1159/000493016
Publikováno v:
Cancer Research. 77:P2-05
Triple-negative breast cancer (TNBC), lacking the steroid hormone receptors estrogen receptor and progesterone receptor and not overexpressing the oncoprotein HER2, is characterized by its aggressive pattern and insensitivity to endocrine and HER2-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27f85121eadf9cf3687562babafcaae3
https://doi.org/10.1158/1538-7445.sabcs16-p2-05-32
https://doi.org/10.1158/1538-7445.sabcs16-p2-05-32