An old dream revitalised: preconditioning strategies to protect surgical flaps from critical ischaemia and ischaemia-reperfusion injury

Autor: Georg Germann, Michaela Amon, Dominik Erni, Markus V. Küntscher, Michael D. Menger, Yves Harder, Brigitte Vollmar, A. Frick, J. Bastiaanse, René Schramm, Martin Rücker, M. W. Laschke, H-G Machens, Reto Wettstein

Publikováno v: Journal of Plastic, Reconstructive & Aesthetic Surgery. 61:503-511

The prevention of ischaemia and the adequate restitution of blood flow to ischaemic tissue are pivotal to halt the progression of cellular injury associated with decreased oxygen and nutrient supply. Accordingly, the search for novel strategies which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ce6f277bd47bb2c0e8b39a067e85e3
https://doi.org/10.1016/j.bjps.2007.11.032

Heat Shock Preconditioning Reduces Ischemic Tissue Necrosis by Heat Shock Protein (HSP)-32-Mediated Improvement of the Microcirculation Rather Than Induction of Ischemic Tolerance

Autor: Dominique Erni, Yves Harder, Andrej Banic, Michaela Amon, Mirko Georgi, Michael D. Menger, René Schramm

Publikováno v: Annals of Surgery. 242:869-879

Introduction: Supraphysiologic stress induces a heat shock response, which may exert protection against ischemic necrosis. Herein we analyzed in vivo whether the induction of heat shock protein (HSP) 32 improves survival of chronically ischemic myocu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80c1d8d618358768c194277423c300f
https://doi.org/10.1097/01.sla.0000189671.06782.56

Experimental models to study microcirculatory dysfunction in muscle ischemia?reperfusion and osteomyocutaneous flap transfer

Autor: Matthias W. Laschke, Martin Rücker, Brigitte Vollmar, Michael D. Menger, René Schramm, Michaela Amon, Henrik Thorlacius

Publikováno v: Langenbeck's Archives of Surgery. 388:281-290

During the past decade, experimental studies have provided convincing evidence that microcirculatory dysfunction plays a pivotal role in the manifestation of tissue injury in ischemia-reperfusion and osteomyocutaneous flap transfer. The study of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b86a7071515172c0b484cee9d5768fd
https://doi.org/10.1007/s00423-003-0426-y

Erythropoietin reduces necrosis in critically ischemic myocutaneous tissue by protecting nutritive perfusion in a dose-dependent manner

Autor: René Schramm, Martin Rücker, Claudio Contaldo, Yves Harder, Michael D. Menger, Michaela Amon, Eva Metzkow, Anne Matzen, Brigitte Vollmar

Publikováno v: Surgery, Vol. 145, No 4 (2009) pp. 372-383

BACKGROUND: Erythropoietin (Epo), the primary regulator of erythropoiesis, has recently been shown to exert antiinflammatory and antiapoptotic properties in neuronal and myocardial tissue. We herein studied whether Epo pretreatment can reduce cell de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdc4e90756a4fddc1b6477fd447e197
https://doi.org/10.5167/uzh-30414

N-Acetylcystein verbessert das Überleben kritisch perfundierter Lappen durch Reduktion der leukozytären Entzündungsreaktion und durch Protektion der nutritiven Kapillarperfusion

Autor: A. Bächle, Michael D. Menger, Michaela Amon, P. Mörsdorf, Yves Harder

Publikováno v: 125. Kongress der Deutschen Gesellschaft für Chirurgie; 20080422-20080425; Berlin; DOC08dgch9727 /20080416/
Chirurgisches Forum 2008 ISBN: 9783540788218

Introduction: Persistent ischemia is often associated with the release of reactive oxygen species and endothelial dysfunction. Accordingly, tissue inflammation may result in wound breakdown and tissue necrosis. Antioxidative treatment has been attrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abc71439738bdfaa81c6858413fe4cb
http://www.egms.de/en/meetings/dgch2008/08dgch126.shtml