Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michaela Aigner"'
Autor:
Gerlinde Doenz, Sebastian Dorn, Narges Aghaallaei, Baubak Bajoghli, Elisabeth Riegel, Michaela Aigner, Holger Bock, Birgit Werner, Thomas Lindhorst, Thomas Czerny
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background The application of antisense molecules, such as morpholino oligonucleotides, is an efficient method of gene inactivation in vivo. We recently introduced phosphonic ester modified peptide nucleic acids (PNA) for in vivo loss-of-fun
Externí odkaz:
https://doaj.org/article/ebcc5c44420f40ddbd3a7bce3da58446
Autor:
Elisabeth Riegel, Holger Bock, Matthias Vonbrüll, Thomas Czerny, Thomas Lindhorst, Christian Halter, Birgit Werner, Michaela Aigner
Publikováno v:
Molecular Biotechnology
There have been many attempts to unveil the therapeutic potential of antisense molecules during the last decade. Due to its specific role in canonical Wnt signalling, β-catenin is a potential target for an antisense-based antitumour therapy. In orde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f7eeb3ac73a4b7fc9885493950b284
https://doi.org/10.1007/s12033-018-0058-7
https://doi.org/10.1007/s12033-018-0058-7
Autor:
Michaela Aigner, Sebastian Dorn, Baubak Bajoghli, Elisabeth Riegel, Holger Bock, Birgit Werner, Thomas Lindhorst, Narges Aghaallaei, Thomas Czerny, Gerlinde Doenz
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-14 (2018)
BMC Biotechnology
BMC Biotechnology
Background The application of antisense molecules, such as morpholino oligonucleotides, is an efficient method of gene inactivation in vivo. We recently introduced phosphonic ester modified peptide nucleic acids (PNA) for in vivo loss-of-function exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3599277a6e1e0cfc56811727ed705cc2
http://archiv.ub.uni-heidelberg.de/volltextserver/24277/
http://archiv.ub.uni-heidelberg.de/volltextserver/24277/
Autor:
Eric Ennifar, Katja Fauster, Michaela Aigner, Christoph Kreutz, Tobias Santner, Ronald Micura, Markus Hartl, Klaus Bister
Publikováno v:
ACS Chemical Biology
Chemical modification can significantly enrich the structural and functional repertoire of ribonucleic acids and endow them with new outstanding properties. Here, we report the syntheses of novel 2'-azido cytidine and 2'-azido guanosine building bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46696a4553eeead654bd080b25ceb092
https://doi.org/10.1021/cb200510k
https://doi.org/10.1021/cb200510k
Publikováno v:
Nucleic Acids Research
Site-specifically modified 2’-methylseleno RNA represents a valuable derivative for phasing of X-ray crystallographic data. Several successful applications in three-dimensional structure determination of nucleic acids, such as the Diels–Alder rib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4557ebd8d361d70c775a59b637ced5
http://europepmc.org/articles/PMC2241898
http://europepmc.org/articles/PMC2241898
Publikováno v:
Chembiochem
One of the most important scientific discoveries in the recent past concerns RNA interference (RNAi), which is a post-transcriptional gene-silencing mechanism induced by small interfering RNA (siRNA) and micro-RNA (miRNA).[1] RNAi has opened up new a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990202d56a42ef9de68b3c24f97e66f0
https://pubmed.ncbi.nlm.nih.gov/21171007
https://pubmed.ncbi.nlm.nih.gov/21171007
Autor:
Jessica Steger, Dagmar Graber, Ronald Micura, Michaela Aigner, Holger Moroder, Anna-Skrollan Geiermann
Publikováno v:
Angewandte Chemie (International ed. in English). 49(41)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04afe42c58c3bd8033b5f63dc066daff
https://pubmed.ncbi.nlm.nih.gov/21038451
https://pubmed.ncbi.nlm.nih.gov/21038451
Publikováno v:
Nature chemical biology. 7(6)
Riboswitches are gene regulation elements in mRNA that function by specifically responding to metabolites. Although the metabolite-bound states of riboswitches have proven amenable to structure determination efforts, knowledge of the structural featu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d26e389b9c07c89c898ecdded35359
https://pubmed.ncbi.nlm.nih.gov/21587253
https://pubmed.ncbi.nlm.nih.gov/21587253
Autor:
Matthias D. Erlacher, Nina Clementi, Michaela Aigner, Marek Zywicki, Anna Chirkova, Norbert Polacek
Publikováno v:
Nucleic Acids Research
Despite the fact that all 23S rRNA nucleotides that build the ribosomal peptidyl transferase ribozyme are universally conserved, standard and atomic mutagenesis studies revealed the nucleobase identities being non-critical for catalysis. This indicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127de1503043e6f72063548a3231f6a2
https://pubmed.ncbi.nlm.nih.gov/20375101
https://pubmed.ncbi.nlm.nih.gov/20375101