Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Michaela A. Ihle"'
Autor:
Michaela A. Ihle, Carina Heydt, Anne Maria Schultheis, Robert Stöhr, Florian Haller, Sylvia Herold, Daniela Aust, Wolfgang Dietmaier, Matthias Evert, Markus Eszlinger, Anja Haak, Silke Laßmann, Daniela Vorholt, Frank Breitenbücher, Martin Werner, Anna Streubel, Thomas Mairinger, Maja Grassow-Narlik, Sabine Merkelbach-Bruse
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Insertion mutations in exon 20 of the epidermal growth factor receptor gene (EGFR exon20ins) are rare, heterogeneous alterations observed in non-small cell lung cancer (NSCLC). With a few exceptions, they are associated with primary resistan
Externí odkaz:
https://doaj.org/article/9fbf9687d08840bb993f42908b606080
Autor:
Jana Fassunke, Fabienne Müller, Marina Keul, Sebastian Michels, Marcel A. Dammert, Anna Schmitt, Dennis Plenker, Jonas Lategahn, Carina Heydt, Johannes Brägelmann, Hannah L. Tumbrink, Yannic Alber, Sebastian Klein, Alena Heimsoeth, Ilona Dahmen, Rieke N. Fischer, Matthias Scheffler, Michaela A. Ihle, Vanessa Priesner, Andreas H. Scheel, Svenja Wagener, Anna Kron, Konrad Frank, Katia Garbert, Thorsten Persigehl, Michael Püsken, Stefan Haneder, Bernhard Schaaf, Ernst Rodermann, Walburga Engel-Riedel, Enriqueta Felip, Egbert F. Smit, Sabine Merkelbach-Bruse, H. Christian Reinhardt, Stefan M. Kast, Jürgen Wolf, Daniel Rauh, Reinhard Büttner, Martin L. Sos
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Acquired resistance to targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. Here, the authors show how the acquired EGFR G724S mutation induces resistance to third-generation EGFR inhibitors and why the mutant kinase rem
Externí odkaz:
https://doaj.org/article/d0509a8e9f1241e6a692b9bd9e5d0a9b
Autor:
Michaela Angelika Ihle, Carina Heydt
Publikováno v:
Die Pathologie. 44:193-196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeaaf984aab2352360345f802d00f8bf
https://doi.org/10.1007/s00292-023-01189-2
https://doi.org/10.1007/s00292-023-01189-2
Autor:
Jürgen Wolf, Reinhard Büttner, Mathieu Clement-Ziza, Lukas C. Heukamp, Britta Kaminsky, Thomas Geist, Ulrich Gerigk, Yon-Dschun Ko, Monika Serke, Carina Heydt, Jana Fassunke, Anna Eisert, Rieke Fischer, Sebastian Michels, Katharina König, Frank Ueckeroth, Michael Rauer, Anna Kron, Michaela A. Ihle, Sabine Merkelbach-Bruse, Matthias Scheffler, Rieke Frank
Supplemental Table 1-7 Supplemental Table 1: Diagnostic panels used for Next-generation sequencing (NGS) Supplemental Table 2: KEAP1 mutations Supplemental Table 3: NFE2L2 mutations Supplemental Table 4: Co-aberrations of KEAP1 Supplemental Table 5:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f036f5e01c6e1155e337dc9abeb9da
https://doi.org/10.1158/1078-0432.22470680
https://doi.org/10.1158/1078-0432.22470680
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Concomitant inhibition of MEK and EGFR is synergistic in PC9KRAS-G12S and HCC827KRAS-G12S cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b61377c2454362cbbfe49a2f4a2410
https://doi.org/10.1158/1078-0432.22460892.v1
https://doi.org/10.1158/1078-0432.22460892.v1
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Activation of ERBB2 or MET leads to decreased sensitivity to AZD9291 and rociletinib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2dd86286d7696bf9b7afa255459cd3
https://doi.org/10.1158/1078-0432.22460904
https://doi.org/10.1158/1078-0432.22460904
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83ce9cf1e2f74d9d238de9825be4cb3
https://doi.org/10.1158/1078-0432.22460907.v1
https://doi.org/10.1158/1078-0432.22460907.v1
Autor:
Jürgen Wolf, Reinhard Büttner, Mathieu Clement-Ziza, Lukas C. Heukamp, Britta Kaminsky, Thomas Geist, Ulrich Gerigk, Yon-Dschun Ko, Monika Serke, Carina Heydt, Jana Fassunke, Anna Eisert, Rieke Fischer, Sebastian Michels, Katharina König, Frank Ueckeroth, Michael Rauer, Anna Kron, Michaela A. Ihle, Sabine Merkelbach-Bruse, Matthias Scheffler, Rieke Frank
Purpose: KEAP1 and NFE2L2 mutations are associated with impaired prognosis in a variety of cancers and with squamous cell carcinoma formation in non–small cell lung cancer (NSCLC). However, little is known about frequency, histology dependence, mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438570b1ec0685eb9b4c9f90d1ab3452
https://doi.org/10.1158/1078-0432.c.6527654.v1
https://doi.org/10.1158/1078-0432.c.6527654.v1
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Purpose: To identify novel mechanisms of resistance to third-generation EGFR inhibitors in patients with lung adenocarcinoma that progressed under therapy with either AZD9291 or rociletinib (CO-1686).Experimental Design: We analyzed tumor biopsies fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e662a6890eec82b0f8c48767ccf2e60
https://doi.org/10.1158/1078-0432.c.6524634
https://doi.org/10.1158/1078-0432.c.6524634
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Targeted and Sanger sequencing results at the EGFR locus for P6 and P7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e81b48ee2be8da8f7783d22fac8ebd1
https://doi.org/10.1158/1078-0432.22460901
https://doi.org/10.1158/1078-0432.22460901