Výsledky vyhledávání - "Michaela, Patz"

B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides

Autor: Valeska Feldhaus, Susanne Brodesser, Michael A. Baumann, Michaela Patz, Julia Claasen, Michael Hallek, Reinhild Brinker, Christian P. Pallasch, Clemens-Martin Wendtner, Lukas P. Frenzel, Janine Schwamb

Publikováno v: Blood. 120:3978-3985

Survival of chronic lymphocytic leukemia (CLL) cells is triggered by several stimuli, such as the B-cell receptor (BCR), CD40 ligand (CD40L), or interleukin-4 (IL-4). We identified that these stimuli regulate apoptosis resistance by modulating sphing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab605c28f6c07eb3e9f4294449d60f35
https://doi.org/10.1182/blood-2012-05-431783

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Comparison of the Effects of Two Kinase Inhibitors, Sorafenib and Dasatinib, on Chronic Lymphocytic Leukemia Cells

Autor: Lukas P. Frenzel, Michaela Patz, Iris Gehrke, Michael Hallek, Günter Krause, Julia Claasen, Mirjam Kuckertz, Aditya Veldurthy, Clemens-Martin Wendtner

Publikováno v: Oncology Research and Treatment. 35:420-426

With sorafenib displaying the highest affinities for Flt3, VEGFR (vascular endothelial growth factor receptor) and Raf and dasatinib for Abl and Src kinases, the profiles of kinases targeted by these inhibitors differ strongly.Dose-dependent effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af285063484ffec438a2d4a228c9c61
https://doi.org/10.1159/000341081

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Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells

Autor: Giinter Krause, Michael Hallek, Nche Forcob, Christian Klein, Polina Isaeva, Pablo Umana, Clemens-Martin Wendtner, Bianka Müller, Michaela Patz, Lukas P. Frenzel

Publikováno v: British Journal of Haematology. 152:295-306

The effects of two CD20 antibodies, namely rituximab, the current standard for treatment of chronic lymphocytic leukaemia (CLL) in combination with chemotherapy, and GA101, a glyco-engineered type II antibody were compared on CLL cells ex vivo. Antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::970fe890d5b7aa97934081bcf3e5e15e
https://doi.org/10.1111/j.1365-2141.2010.08428.x

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Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis

Autor: Lukas P. Frenzel, Reinhild Brinker, Christian P. Pallasch, Hamid Kashkar, Julia Claasen, Michaela Patz, Michael Hallek, Alexandra Schulz, Clemens-Martin Wendtner

Publikováno v: British Journal of Haematology. 152:191-200

Given that aggressive DNA damaging chemotherapy shows suboptimal efficacy in chronic lymphocytic leukaemia (CLL), alternative therapeutic approaches are needed. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is able to induce tumour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::171065e28625155585d09c2010975859
https://doi.org/10.1111/j.1365-2141.2010.08426.x

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miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia

Autor: Christian P. Pallasch, Christine Mayr, Nadine Kutsch, Joachim L. Schultze, Yoon Jung Park, Clemens-Martin Wendtner, Andreas Rosenwald, Rainer Claus, Alexandra Schulz, Günter Krause, Christoph Plass, Michaela Patz, Daniela Eggle, Svenja Debey-Pascher, Julia Claasen, Lukas P. Frenzel, Michael Hallek, Susanne Hagist

Publikováno v: Blood. 114:3255-3264

MicroRNAs (miRNA) play a key role in cellular regulation and, if deregulated, in the development of neoplastic disorders including chronic lymphocytic leukemia (CLL). RNAs from primary cells of 50 treatment-naive CLL patients and peripheral B cells o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96aedcab8f55e721ca05507a1e4a31c8
https://doi.org/10.1182/blood-2009-06-229898

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Critical role of microRNAs in chronic lymphocytic leukemia: overexpression of the oncogene PLAG1 by deregulated miRNAs

Autor: Michaela Patz, Clemens-Martin Wendtner, Christian P. Pallasch

Publikováno v: Leukemia & Lymphoma. 51:1379-1381

MicroRNAs (miRNAs) are small, gene encoded RNAs which are able to influence gene expression in binding to the 3'UTR of mRNAs. Compared to healthy tissues, the global expression of miRNAs in cancerous tissue is frequently down-regulated. Likewise in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7099b3722bbec9c67a4ca2fcdbb593
https://doi.org/10.3109/10428194.2010.496016

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In Vitro Sensitivity Testing in the Assessment of Anti-CLL Drug Candidates

Autor: Susan Kerwien, Michael Hallek, Michaela Patz, Günter Krause, Mirjam Kuckertz

Publikováno v: Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of morphologically mature, but immuno-incompetent B-lymphocytes in the bone marrow, peripheral blood, spleen and lymphoid organs. With an annual incidence of about 2-3/ 100000 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daea823f1f92195acdfe6b5d40599527
https://doi.org/10.5772/27087

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