Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Michaela, Kuhn"'
Autor:
Swati Dabral, Minhee Noh, Franziska Werner, Lisa Krebes, Katharina Völker, Christopher Maier, Ivan Aleksic, Tatyana Novoyatleva, Stefan Hadzic, Ralph Theo Schermuly, Vinicio A. de Jesus Perez, Michaela Kuhn
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Pericyte dysfunction, with excessive migration, hyperproliferation, and differentiation into smooth muscle-like cells contributes to vascular remodeling in Pulmonary Arterial Hypertension (PAH). Augmented expression and action of growth fact
Externí odkaz:
https://doaj.org/article/18973130b80a40d0ba8004c80ae59304
Autor:
Franziska Werner, Takashi Naruke, Lydia Sülzenbrück, Sarah Schäfer, Melanie Rösch, Katharina Völker, Lisa Krebes, Marco Abeßer, Dorothe Möllmann, Hideo A. Baba, Frank Schweda, Alma Zernecke, Michaela Kuhn
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7800 (2024)
Endothelial dysfunction is cause and consequence of cardiovascular diseases. The endothelial hormone C-type natriuretic peptide (CNP) regulates vascular tone and the vascular barrier. Its cGMP-synthesizing guanylyl cyclase-B (GC-B) receptor is expres
Externí odkaz:
https://doaj.org/article/9f98b9906f7e4e0c96273ae0792c7c1f
Autor:
Franziska Werner, Estefania Prentki Santos, Konstanze Michel, Hanna Schrader, Katharina Völker, Tamara Potapenko, Lisa Krebes, Marco Abeßer, Dorothe Möllmann, Martin Schlattjan, Hannes Schmidt, Boris V. Skryabin, Katarina Špiranec Spes, Kai Schuh, Christopher P. Denton, Hideo A. Baba, Michaela Kuhn
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Excessive activation of cardiac fibroblasts (CFs) in response to injury provokes cardiac fibrosis, stiffness, and failure. The local mediators counterregulating this response remain unclear. Exogenous C-type natriuretic peptide (CNP) exerts antifibro
Externí odkaz:
https://doaj.org/article/7283f518feaf421cb1374fda596e995c
Publikováno v:
World Development Sustainability, Vol 2, Iss , Pp 100034- (2023)
Most cocoa is grown by smallholder farmers whose livelihoods depend largely on the income from cocoa. Today, cocoa production must increasingly comply with social and environmental requirements as the worldwide demand for sustainably produced cocoa i
Externí odkaz:
https://doaj.org/article/62b79f9dbfcd43578ad326b1892eab8b
Autor:
Malgorzata Szaroszyk, Badder Kattih, Abel Martin-Garrido, Felix A. Trogisch, Gesine M. Dittrich, Andrea Grund, Aya Abouissa, Katja Derlin, Martin Meier, Tim Holler, Mortimer Korf-Klingebiel, Katharina Völker, Tania Garfias Macedo, Cristina Pablo Tortola, Michael Boschmann, Nora Huang, Natali Froese, Carolin Zwadlo, Mona Malek Mohammadi, Xiaojing Luo, Michael Wagner, Julio Cordero, Robert Geffers, Sandor Batkai, Thomas Thum, Nadja Bork, Viacheslav O. Nikolaev, Oliver J. Müller, Hugo A. Katus, Ali El-Armouche, Theresia Kraft, Jochen Springer, Gergana Dobreva, Kai C. Wollert, Jens Fielitz, Stephan von Haehling, Michaela Kuhn, Johann Bauersachs, Joerg Heineke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cachexia is associated with poor prognosis in heart failure. Here the authors show that mice and patients with cardiac cachexia display reduced skeletal muscle expression and circulating levels of Musclin. Musclin ablation in skeletal muscle worsens,
Externí odkaz:
https://doaj.org/article/95984c1d58cc4de49ae09f7ddb642716
Autor:
Yiliam Cruz-Garcia, Katalin Barkovits, Michael Kohlhaas, Simone Pickel, Michelle Gulentz, Cornelia Heindl, Kathy Pfeiffer, Petra Eder-Negrin, Christoph Maack, Katrin Marcus, Michaela Kuhn, Erick Miranda-Laferte
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
In cardiomyocytes, Ca2+ influx through L-type voltage-gated calcium channels (LTCCs) following membrane depolarization regulates crucial Ca2+-dependent processes including duration and amplitude of the action potentials and excitation-contraction cou
Externí odkaz:
https://doaj.org/article/26932e115a884cb2a0bbc81964f20baa
Autor:
Nadja I. Bork, Anna Kuret, Melanie Cruz Santos, Cristina E. Molina, Beate Reiter, Hermann Reichenspurner, Andreas Friebe, Boris V. Skryabin, Timofey S. Rozhdestvensky, Michaela Kuhn, Robert Lukowski, Viacheslav O. Nikolaev
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102179- (2021)
3′,5′-cyclic guanosine monophosphate (cGMP) is a druggable second messenger regulating cell growth and survival in a plethora of cells and disease states, many of which are associated with hypoxia. For example, in myocardial infarction and heart
Externí odkaz:
https://doaj.org/article/06f06ef82ac1467b9416c06fe88290d6
Autor:
Philipp Tauber, Frederick Sinha, Raffaela S. Berger, Wolfram Gronwald, Katja Dettmer, Michaela Kuhn, Maximilian Trum, Lars S. Maier, Stefan Wagner, Frank Schweda
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Large-scale clinical outcome studies demonstrated the efficacy of SGLT2 inhibitors in patients with type II diabetes. Besides their therapeutic efficacy in diabetes, significant renoprotection was observed in non-diabetic patients with chronic kidney
Externí odkaz:
https://doaj.org/article/425b5cc5bd5d407aabe01f2b4f8ecc5e
Autor:
Simone Pickel, Yiliam Cruz-Garcia, Sandra Bandleon, Katalin Barkovits, Cornelia Heindl, Katharina Völker, Marco Abeßer, Kathy Pfeiffer, Alice Schaaf, Katrin Marcus, Petra Eder-Negrin, Michaela Kuhn, Erick Miranda-Laferte
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cavα1 pore-forming subunit and the accessory subunits Cavβ, Cavα2δ, and Cavγ. Cavβ is a cytosolic protein that regulat
Externí odkaz:
https://doaj.org/article/495d0eff559d40d68167f7a27d6ea5de
Autor:
Konstanze Michel, Melissa Herwig, Franziska Werner, Katarina Špiranec Spes, Marco Abeßer, Kai Schuh, Swati Dabral, Andreas Mügge, Hideo A. Baba, Boris V. Skryabin, Nazha Hamdani, Michaela Kuhn
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
Heart failure is often accompanied by titin-dependent myocardial stiffness. Phosphorylation of titin by cGMP-dependent protein kinase I (PKGI) increases cardiomyocyte distensibility. The upstream pathways stimulating PKGI-mediated titin phosphorylati
Externí odkaz:
https://doaj.org/article/bc488a37aaa24a19ac2437a35f753e5f