Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Michaela, Blech"'
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Protein formulation development relies on the selection of excipients that inhibit protein–protein interactions preventing aggregation. Empirical strategies involve screening many excipient and buffer combinations by physicochemical characterizatio
Externí odkaz:
https://doaj.org/article/aec81e049a054a3e9da552a48049433a
Autor:
Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker, Fabian Higel
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
During the development process of therapeutic monoclonal antibodies (mAbs), it is crucial to control (critical) quality attributes such as N-glycosylation influencing pharmacokinetics (PK) and Fc effector functions. Previous reports have shown that m
Externí odkaz:
https://doaj.org/article/82113cfad990463fbe7accf6eac23a11
Autor:
Kristina M.J. Aertker, Minu Ravindra Pilvankar, Tobias M. Prass, Michaela Blech, Fabian Higel, Srinath Kasturirangan
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Bispecific antibodies (BsAbs) capable of recognizing two distinct epitopes or antigens offer promising therapeutic options for various diseases by targeting multiple pathways. The favorable pharmacokinetic (PK) properties of monoclonal antibodies (mA
Externí odkaz:
https://doaj.org/article/1c603c903ef24f8ab169d4e15eb01906
Autor:
Elena Hipper, Florian Lehmann, Wolfgang Kaiser, Göran Hübner, Julia Buske, Michaela Blech, Dariush Hinderberger, Patrick Garidel
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100155- (2023)
Visible light (400–800 nm) can lead to photooxidation of protein formulations, which might impair protein integrity. However, the relevant mechanism of photooxidation upon visible light exposure is still unclear for therapeutic proteins, since prot
Externí odkaz:
https://doaj.org/article/7cc94d0fe43b4541ae395f6342387dc1
Autor:
Luisa Stroppel, Torsten Schultz-Fademrecht, Martin Cebulla, Michaela Blech, Richard J. Marhöfer, Paul M. Selzer, Patrick Garidel
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 563 (2023)
Biological drugs intended for multi-dose application require the presence of antimicrobial preservatives to avoid microbial growth. As the presence of certain preservatives has been reported to increase protein and peptide particle formation, it is e
Externí odkaz:
https://doaj.org/article/8d498e215cc642b898229db9c9c84504
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 185:55-70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af4f11816ef9f75ac18b189070372a4
https://doi.org/10.1016/j.ejpb.2023.01.017
https://doi.org/10.1016/j.ejpb.2023.01.017
Autor:
Joschka Bauer, Sven Mathias, Sebastian Kube, Kerstin Otte, Patrick Garidel, Martin Gamer, Michaela Blech, Simon Fischer, Anne R Karow-Zwick
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The discovery of therapeutic monoclonal antibodies (mAbs) primarily focuses on their biological activity favoring the selection of highly potent drug candidates. These candidates, however, may have physical or chemical attributes that lead to unfavor
Externí odkaz:
https://doaj.org/article/4b709eb7b77347208fd2e1baab40e518
Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 72 (2021)
UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation
Externí odkaz:
https://doaj.org/article/3bfe42c26f814ea6a6cff7acbb295f72
Autor:
Josef Hartl, Sergej Friesen, Diethelm Johannsmann, Richard Buchner, Dariush Hinderberger, Michaela Blech, Patrick Garidel
Publikováno v:
Molecular Pharmaceutics. 19:494-507
Molecular interaction mechanisms in high-concentrated protein systems are of fundamental importance for the rational development of biopharmaceuticals such as monoclonal antibody (mAb) formulations. In such high-concentrated protein systems, the inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4aaf11dd35511e0f816536a3fa9ebc
https://doi.org/10.1021/acs.molpharmaceut.1c00587
https://doi.org/10.1021/acs.molpharmaceut.1c00587
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1112 (2020)
Detection and characterization of particles in the visible and subvisible size range is critical in many fields of industrial research. Commercial particle analysis systems have proliferated over the last decade. Despite that growth, most systems con
Externí odkaz:
https://doaj.org/article/0f17d932df4a4e55bb48380a89603820