Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Michael. J. Watson"'
Autor:
Annie Dosey, Daniel Ellis, Seyhan Boyoglu-Barnum, Hubza Syeda, Mason Saunders, Michael J. Watson, John C. Kraft, Minh N. Pham, Miklos Guttman, Kelly K. Lee, Masaru Kanekiyo, Neil P. King
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113553- (2023)
Summary: The receptor-binding domain (RBD) of influenza virus hemagglutinin (HA) elicits potently neutralizing yet mostly strain-specific antibodies. Here, we evaluate the ability of several immunofocusing techniques to enhance the functional breadth
Externí odkaz:
https://doaj.org/article/3cefb334ae1442beba2b9a737c54329f
Autor:
Brittany Butts, PhD, Mustafa I. Ahmed, MD, Navkaranbir S. Bajaj, MD, MPH, Pamela Cox Powell, MS, Betty Pat, PhD, Silvio Litovsky, MD, Himanshu Gupta, MD, Steven G. Lloyd, MD, Thomas S. Denney, PhD, Xiaoxia Zhang, PhD, Inmaculada Aban, PhD, Sakthivel Sadayappan, PhD, MBA, James W. McNamara, PhD, Michael J. Watson, PhD, Carlos M. Ferrario, MD, James F. Collawn, PhD, Clifton Lewis, MD, James E. Davies, MD, Louis J. Dell’Italia, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 109-122 (2020)
Summary: Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enl
Externí odkaz:
https://doaj.org/article/8b2e10df0b604a758f656d121b3eff40
Autor:
Yuliang Feng, Liuyang Cai, Wanzi Hong, Chunxiang Zhang, Ning Tan, Mingyang Wang, Cheng Wang, Feng Liu, Xiaohong Wang, Jianyong Ma, Chen Gao, Mohit Kumar, Yuanxi Mo, Qingshan Geng, Changjun Luo, Yan Lin, Haiyang Chen, Shuang-Yin Wang, Michael J. Watson, Anil G. Jegga, Roger A. Pedersen, Ji-dong Fu, Zhao V. Wang, Guo-Chang Fan, Sakthivel Sadayappan, Yigang Wang, Siim Pauklin, Feng Huang, Wei Huang, Lei Jiang
Publikováno v:
Circulation
Background: Transcriptional reconfiguration is central to heart failure, the most common cause of which is dilated cardiomyopathy (DCM). The effect of 3-dimensional chromatin topology on transcriptional dysregulation and pathogenesis in human DCM rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47dd87ce7e8e59aa8b3862782535c15d
https://doi.org/10.1161/circulationaha.121.055781
https://doi.org/10.1161/circulationaha.121.055781
Autor:
W. Wilson McNeary, Jacob H. Miller, Sean A. Tacey, Jonathan Travis, Gabriella D. Lahti, Michael B. Griffin, Katherine L. Jungjohann, Glenn Teeter, Tugce Eralp Erden, Carrie A. Farberow, Luke Tuxworth, Michael J. Watson, Arrelaine A. Dameron, Derek R. Vardon
Publikováno v:
Chemical Engineering Journal. 467:143268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7f735bbd014669769b8a25a38450ebe
https://doi.org/10.1016/j.cej.2023.143268
https://doi.org/10.1016/j.cej.2023.143268
Autor:
Malika Hale, Jason Netland, Yu Chen, Christopher D. Thouvenel, Katherine Nabel Smith, Lucille M. Rich, Elizabeth R. Vanderwall, Marcos C. Miranda, Julie Eggenberger, Linhui Hao, Michael J. Watson, Charles C. Mundorff, Lauren B. Rodda, Neil P. King, Miklos Guttman, Michael Gale, Jonathan Abraham, Jason S. Debley, Marion Pepper, David J. Rawlings
Publikováno v:
Journal of Experimental Medicine. 219
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa4ec6b71eae04027dd17c9bad6c227f
https://doi.org/10.1084/jem.2022084908172022c
https://doi.org/10.1084/jem.2022084908172022c
Autor:
Juan Pablo Rincon Pabon, Clint Vorauer, Michael S. Wrigley, David D. Weis, Charlie C. Mundorff, Michael J. Watson, Miklos Guttman
Publikováno v:
Journal of the American Society for Mass Spectrometry. 32:2386-2390
Hydrogen/deuterium exchange with mass spectrometry (HDX-MS) is a widely used technique to probe protein structural dynamics, track conformational changes, and map protein-protein interactions. Most HDX-MS studies employ a bottom-up approach utilizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8f2be57c27ab777cb70adfa2870237
https://doi.org/10.1021/jasms.1c00080
https://doi.org/10.1021/jasms.1c00080
Autor:
Masaru Kanekiyo, Lance Stewart, George Ueda, Rashmi Ravichandran, Nick Matheson, Miklos Guttman, Young-Jun Park, David Veesler, John R. Mascola, Syed M. Moin, Adrian Creanga, Barney S. Graham, Daniel Ellis, John R. Vaile, Deleah Pettie, Geoffrey B. Hutchinson, David Baker, Sila Ataca, Lauren Carter, Michael E. P. Murphy, Oliver J. Acton, Rebecca A. Gillespie, Michelle C. Crank, Neil P. King, Seyhan Boyoglu-Barnum, Sally Kephart, Michael J. Watson, Kelly K. Lee
Publikováno v:
Nature
Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and immunization1. Here we show that computationally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc566257472cb8f9c45fdebbd4a3da49
http://europepmc.org/articles/PMC8269962
http://europepmc.org/articles/PMC8269962
Autor:
Malika Hale, Jason Netland, Yu Chen, Christopher D. Thouvenel, Katherine Nabel Smith, Lucille M. Rich, Elizabeth R. Vanderwall, Marcos C. Miranda, Julie Eggenberger, Linhui Hao, Michael J. Watson, Charles C. Mundorff, Lauren B. Rodda, Neil P. King, Miklos Guttman, Michael Gale, Jonathan Abraham, Jason S. Debley, Marion Pepper, David J. Rawlings
Publikováno v:
The Journal of experimental medicine. 219(9)
Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from convalescent donors or an engineered monoclonal antibody (mAb) product. While pentameric IgM antibodies are responsible for much of convalescent sera’s neutralizing capaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2ad5a20085cb3b87ebd4b689c5e4a4
https://pubmed.ncbi.nlm.nih.gov/36036783
https://pubmed.ncbi.nlm.nih.gov/36036783
Autor:
Muath Bishawi, Adam Nevo, Dawn E. Bowles, Michael J. Watson, Zachary D. Brown, Jun Neng Roan, Franklin H. Lee
Publikováno v:
BioTechniques. 69:6-10
The generation of an experimental animal model often requires considerable investment of both time and money. Typically, investigators are interested in specific organs and when experimental animals are euthanized, tissues that are not the focus of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d05e81123662ac59fd4b1976bb2ca2
https://doi.org/10.2144/btn-2019-0069
https://doi.org/10.2144/btn-2019-0069
Autor:
Inmaculada Aban, Thomas S. Denney, Navkaranbir S. Bajaj, Mustafa I. Ahmed, Michael J. Watson, Carlos M. Ferrario, Xiaoxia Zhang, James E. Davies, Himanshu Gupta, James W. McNamara, Betty Pat, Clifton T. Lewis, Louis J. Dell’Italia, James F. Collawn, Silvio H. Litovsky, Sakthivel Sadayappan, Brittany Butts, Steven G. Lloyd, Pamela C. Powell
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 109-122 (2020)
JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 109-122 (2020)
Visual Abstract
Highlights • Extensive LA fibrosis is related to an increase in LA size and decrease in total LA EF. This supports the contention that the LA is not merely a bystander of MR but rather is actively involved in the pathophysiolog
Highlights • Extensive LA fibrosis is related to an increase in LA size and decrease in total LA EF. This supports the contention that the LA is not merely a bystander of MR but rather is actively involved in the pathophysiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418707eb573e2e315a430793399ff571
http://europepmc.org/articles/PMC7046515
http://europepmc.org/articles/PMC7046515