Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Michael-Robin Witt"'
Autor:
Lisa-Mari Mörk, Stefan Rehnmark, Padideh Davoodpour, Giuseppe Danilo Norata, Lilian Larsson, Michael-Robin Witt, Johan Malm, Paolo Parini
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e78534 (2013)
BACKGROUND: Thyroid hormones (TH) regulate cholesterol metabolism but their use as lipid-lowering drugs is restricted due to negative cardiac effects. TH mimetic compounds modulating TH receptor β (THRβ) have been designed as potential drugs, reduc
Externí odkaz:
https://doaj.org/article/f4e0c781ac524f8d98d68581c14675a0
Autor:
Mogens Nielsen, Michael-Robin Witt
Publikováno v:
Journal of Neurochemistry. 62:1432-1439
We have investigated the effect of unsaturated free fatty acids (FFAs) on the brain GABA/benzodiazepine receptor chloride channel complex from mammalian, avian, amphibian, and fish species in vitro. Unsaturated FFAs with a carbon chain length between
Autor:
Michael Robin Witt, Mogens Nielsen, Helen Wahe, Jinglu Ai, Olov Sterner, Zacharias Tanee Fomum, Xiaomei Wang
Publikováno v:
Pharmacology. 60:175-178
2-Oxo-2H-pyrimido[2,1-b]benzothiazole derivatives were found to inhibit the in vitro binding of 3H-Ro 15-1788 (3H-flumazenil) to rat cortical benzodiazepine receptors with IC50 values in the range of 0.7–13 μmol/l. The most potent compound, 2-oxo-
Autor:
Wolfgang Kromer, Xiaomei Wang, Shigekatsu Kohno, Branislava Brkić, Zacharias Tanee Fomum, Jinglu Ai, Ting Wang, Keith K. Parker, Koichi Shudo, Ikunobu Muramatsu, Hiroichi Nagai, Mogens Nielsen, Toshihisa Kamiki, Yasuko Hiraoka, Satoru Niwa, Takashi Ochi, Yousuke Hirano, Walter B. Severs, Richard Riedel, Naoki Inagaki, Michael-Robin Witt, Takashi Tanpo, Vesna Starcevic, Stefan Postius, Helen Wahe, Takeshi Nabe, Marvin C. Devereaux, Verica Milošević, Thomas C. Ortiz, Olov Sterner, Kiyoshi Yasui, Takanobu Taniguchi, Masafumi Oshita
Publikováno v:
Pharmacology. 60:217-220
Autor:
Mogens Nielsen, Else Saederup, Pia Kahnberg, Michael Robin Witt, Olov Sterner, Richard F. Squires, Jinglu Ai
Publikováno v:
Neurochemical Research. 24:1593-1602
1. The bark of the root and stem of various Magnolia species has been used in Traditional Chinese Medicine to treat a variety of disorders including anxiety and nervous disturbances. The biphenolic compounds honokiol (H) and magnolol (M), the main co
The Heteroyohimbine Mayumbine Binds with High Affinity to Rat Brain Benzodiazepine Receptorsin vitro
Publikováno v:
Natural Product Letters. 11:73-76
Mayumbine, a naturally occurring heteroyohimbine, was isolated from Rauwolfia vomitoria extracts and shown to potently (IC50 = 76 ± 3.5 nM) inhibit the in vitro binding of 3H-diazepam to the benzodiazepine sites within the rat GABAA receptor complex
Publikováno v:
Neurochemistry International. 31:437-446
Antisense oligodeoxynucleotides (ODN) can be used as selective inhibitors of in vivo gene expression in the central nervous system (CNS) of experimental animals. The gamma-aminobutyric acid type A (GABAA) receptor is a member of the ligand-gated ion
Publikováno v:
Brain Research. 765:21-29
Antisense oligodeoxynucleotides (ODNs) are used for the selective inhibition of gene expression. Antisense ODNs are promising tools for the investigation of physiological implications of proteins in the central nervous system of rodents in vivo. We h
Publikováno v:
Drug Development Research. 41:99-106
Seventeen flavonoids were found to have inhibitory activity on the central nervous system GABAA/benzodiazepine (BZD) receptors with IC50 values ranging from 0.12 to 8 μM. 6-Methylflavone, the most potent, was pharmacologically characterized by radio
Autor:
Norio Akaike, Kazuo Noguchi, Svend Hastrup, Svend Erik Westh-Hansen, Poul Baad Rasmussen, Junichi Nabekura, Michael-Robin Witt, Mogens Nielsen
Publikováno v:
European Journal of Pharmacology. 329:253-257
Recombinant human GABAA receptors were investigated in vitro by coexpression of cDNAs coding for α1, β2, and γ2 subunits in the baculovirus/Sf-9 insect cell system. We report that a single amino acid exchange (isoleucine 121 to valine 121) in the