Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Michael gotthardt"'
Autor:
Julia Kornienko, Marta Rodríguez-Martínez, Kai Fenzl, Florian Hinze, Daniel Schraivogel, Markus Grosch, Brigit Tunaj, Dominik Lindenhofer, Laura Schraft, Moritz Kueblbeck, Eric Smith, Chad Mao, Emily Brown, Anjali Owens, Ardan M. Saguner, Benjamin Meder, Victoria Parikh, Michael Gotthardt, Lars M. Steinmetz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich domain (RS-domain). Such mutations can cause defective splic
Externí odkaz:
https://doaj.org/article/22609fd3b5c8440ebce2789206b89798
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
Autor:
Markus Grosch, Laura Schraft, Adrian Chan, Leonie Küchenhoff, Kleopatra Rapti, Anne-Maud Ferreira, Julia Kornienko, Shengdi Li, Michael H. Radke, Chiara Krämer, Sandra Clauder-Münster, Emerald Perlas, Johannes Backs, Michael Gotthardt, Christoph Dieterich, Maarten M. G. van den Hoogenhof, Dirk Grimm, Lars M. Steinmetz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Dilated cardiomyopathy is the second most common cause for heart failure with no cure except a high-risk heart transplantation. Approximately 30% of patients harbor heritable mutations which are amenable to CRISPR-based gene therapy. However
Externí odkaz:
https://doaj.org/article/287d1894c5f548b689b58cdf403063c5
Autor:
Fabian Freiberg, Meghna Thakkar, Wiebke Hamann, Jacobo Lopez Carballo, Rene Jüttner, Felizia K. Voss, Peter M. Becher, Dirk Westermann, Carsten Tschöpe, Arnd Heuser, Oliver Rocks, Robert Fischer, Michael Gotthardt
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 3, Pp 643-652 (2023)
Heart attack: Inhibiting cell contact protein may limit damage During a heart attack the death of heart muscle cells causes lesions that transform into fibrotic tissue. Restricting the damage is critical, as mamalian heart muslce does not regenerate.
Externí odkaz:
https://doaj.org/article/fc2561fd24ba4e1d9192ae9c018ef5fa
Autor:
Anika Neuschulz, Olga Bakina, Victor Badillo‐Lisakowski, Pedro Olivares‐Chauvet, Thomas Conrad, Michael Gotthardt, Helmut Kettenmann, Jan Philipp Junker
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 2, Pp 1-13 (2022)
Abstract Tissue dissociation, a crucial step in single‐cell sample preparation, can alter the transcriptional state of a sample through the intrinsic cellular stress response. Here we demonstrate a general approach for measuring transcriptional res
Externí odkaz:
https://doaj.org/article/082ccd7c192740a3a8f78db215e2cb8b
Autor:
Elena Ortiz-Zapater, Dustin C. Bagley, Virginia Llopis Hernandez, Luke B. Roberts, Thomas J. A. Maguire, Felizia Voss, Philipp Mertins, Marieluise Kirchner, Isabel Peset-Martin, Grzegorz Woszczek, Jody Rosenblatt, Michael Gotthardt, George Santis, Maddy Parsons
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The epithelial protein Coxsackievirus Adenovirus Receptor (CAR) is a virus receptor but may have other functions. Here the authors show that deletion of CAR in mice leads to reduced house dust mite-induced lung inflammation, reduced neutrophil accumu
Externí odkaz:
https://doaj.org/article/c3d25d33aea74f4cbf6de6ff469281a8
Autor:
Jes-Niels Boeckel, Maximilian Möbius-Winkler, Marion Müller, Sabine Rebs, Nicole Eger, Laura Schoppe, Rewati Tappu, Karoline E. Kokot, Jasmin M. Kneuer, Susanne Gaul, Diana M. Bordalo, Alan Lai, Jan Haas, Mahsa Ghanbari, Philipp Drewe-Boss, Martin Liss, Hugo A. Katus, Uwe Ohler, Michael Gotthardt, Ulrich Laufs, Katrin Streckfuss-Bömeke, Benjamin Meder
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 1, Pp 129-146 (2022)
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing is involved in the pathophysiology of heart failure. Mutations in the splicing factor RNA binding motif protein 20 (RBM20)
Externí odkaz:
https://doaj.org/article/1a62d499b1c84c03a1e970a9381d3d3a
Autor:
Gizem Inak, Agnieszka Rybak-Wolf, Pawel Lisowski, Tancredi M. Pentimalli, René Jüttner, Petar Glažar, Karan Uppal, Emanuela Bottani, Dario Brunetti, Christopher Secker, Annika Zink, David Meierhofer, Marie-Thérèse Henke, Monishita Dey, Ummi Ciptasari, Barbara Mlody, Tobias Hahn, Maria Berruezo-Llacuna, Nikos Karaiskos, Michela Di Virgilio, Johannes A. Mayr, Saskia B. Wortmann, Josef Priller, Michael Gotthardt, Dean P. Jones, Ertan Mayatepek, Werner Stenzel, Sebastian Diecke, Ralf Kühn, Erich E. Wanker, Nikolaus Rajewsky, Markus Schuelke, Alessandro Prigione
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Leigh syndrome (LS) is a severe neurometabolic disorder which lacks effective models. Here, the authors developed human neuronal models of LS carrying mutations in SURF1 which show impaired neuronal morphogenesis due to metabolic deficiencies.
Externí odkaz:
https://doaj.org/article/7c5258ec4a0c4d51b4034db5722f87a1
Autor:
Ying-Hsi Lin, Jennifer L. Major, Tim Liebner, Zaynab Hourani, Joshua G. Travers, Sara A. Wennersten, Korey R. Haefner, Maria A. Cavasin, Cortney E. Wilson, Mark Y. Jeong, Yu Han, Michael Gotthardt, Scott K. Ferguson, Amrut V. Ambardekar, Maggie P.Y. Lam, Chunaram Choudhary, Henk L. Granzier, Kathleen C. Woulfe, Timothy A. McKinsey
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin
Externí odkaz:
https://doaj.org/article/150af97ede814fce977a15aa3d27a1dc
Autor:
Franziska Rudolph, Claudia Fink, Judith Hüttemeister, Marieluise Kirchner, Michael H. Radke, Jacobo Lopez Carballo, Eva Wagner, Tobias Kohl, Stephan E. Lehnart, Philipp Mertins, Michael Gotthardt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Titin determines the elasticity of the sarcomere and integrates into both the Z-disc and the M-band. Here, the authors generate a BioID mouse to study the titin interactome at the Z-disc region in neonatal and adult heart and skeletal muscle.
Externí odkaz:
https://doaj.org/article/8f93ea653e124b8e83b6b456aadd7c7e
Publikováno v:
Life, Vol 13, Iss 1, p 14 (2022)
The IgCAM coxsackie–adenovirus receptor (CAR) is essential for embryonic heart development and electrical conduction in the mature heart. However, it is not well-understood how CAR exerts these effects at the cellular level. To address this questio
Externí odkaz:
https://doaj.org/article/fc7e309942804063be4ee1cdcb4b038a