Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael ben Ezra"'
Autor:
Morten Scheibye-Knudsen, Michael Ben Ezra, Jonas Garbrecht, Nasya Rasmussen, Indra Heckenbach, Michael Petr, Daniela Bakula, Laust Mortensen
Little is known about tissue specific changes that occur with aging in humans. Using the description of 33 million histological samples we extract thousands of age- and mortality-associated features from text narratives that we call The Human Pathome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39a8e39cb013bc93e88cc445612a74e0
https://doi.org/10.21203/rs.3.rs-2652110/v1
https://doi.org/10.21203/rs.3.rs-2652110/v1
Autor:
Michael Ben Ezra, Jonas Bach Garbrecht, Nasya Rasmussen, Indra Heckenbach, Michael Angelo Petr, Daniela J Bakula, Laust Hvas Mortensen, Morten Scheibye-Knudsen
Little is known about tissue specific changes that occur with aging in humans. Using the description of 33 million histological samples we extract thousands of age- and mortality-associated features from text narratives that we call The Human Pathome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65398551f52126172c173a56ac94978f
https://doi.org/10.1101/2023.02.27.530179
https://doi.org/10.1101/2023.02.27.530179
Autor:
Kristoffer L. Norheim, Michael Ben Ezra, Indra Heckenbach, Louise Munkholm Andreasson, Mads Vargas Damgaard, Magnus Berglind, Luca Pricolo, Jonas Thue Treebak, Sisse Bolm Ditlev, Celeste Porsbjerg, Morten Scheibye-Knudsen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58e5ca41c6ce2e2914353e9cf6981a9e
https://doi.org/10.2139/ssrn.4425875
https://doi.org/10.2139/ssrn.4425875
Autor:
Michael Angelo Petr, Lina M Carmona-Marin, Tulika Tulika, Stella Kristensen, Simon Reves, Daniela Bakula, Guido Keijzers, Brenna Osborne, Sarah J Mitchell, Sam Hamilton, Jonathan Kato, Irene Alfaras, Amanuel A. Teklu, Indra Heckenbach, Jakob Madsen, Michael Ben Ezra, Garik Mkrtchyan, Erika Varner, Benjamin Fink, Eliana von Krusenstiern, Nathaniel W Snyder, Hector Herranz, Rafael de Cabo, Morten Scheibye-Knudsen
SUMMARYThere is currently no established intervention for Cockayne syndrome, a disease characterized by progressive early onset neurodegeneration with features of premature aging. Here, we tested if acetyl-CoA precursors, citrate and beta-hydroxybuty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cd60a3aee6463049e9191d2cb534bb5
https://doi.org/10.1101/2022.03.08.483430
https://doi.org/10.1101/2022.03.08.483430
Autor:
Indra Heckenbach, Garik V. Mkrtchyan, Michael Ben Ezra, Daniela Bakula, Jakob Sture Madsen, Malte Hasle Nielsen, Denise Oró, Brenna Osborne, Anthony J Covarrubias, M. Laura Idda, Myriam Gorospe, Laust Mortensen, Eric Verdin, Rudi Westendorp, Morten Scheibye-Knudsen
Publikováno v:
Heckenbach, I, Mkrtchyan, G V, Ezra, M B, Bakula, D, Madsen, J S, Nielsen, M H, Oró, D, Osborne, B, Covarrubias, A J, Idda, M L, Gorospe, M, Mortensen, L, Verdin, E, Westendorp, R & Scheibye-Knudsen, M 2022, ' Nuclear morphology is a deep learning biomarker of cellular senescence ', Nature Aging, vol. 2, no. 8, pp. 742-755 . https://doi.org/10.1038/s43587-022-00263-3
Cellular senescence is an important factor in aging and many age-related diseases, but understanding its role in health is challenging due to the lack of exclusive or universal markers. Using neural networks, we predict senescence from the nuclear mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5eda787a7c1be611f28987041f5a0c
https://curis.ku.dk/ws/files/319160606/s43587_022_00263_3.pdf
https://curis.ku.dk/ws/files/319160606/s43587_022_00263_3.pdf
Autor:
Jakob B. Madsen, Garik Mkrtchyan, Morten Scheibye-Knudsen, Rudi G. J. Westendorp, Laust Hvas Mortensen, Myriam Gorospe, Denise Oró, Malte H. Nielsen, Daniela Bakula, Indra Heckenbach, M Laura Idda, Eric Verdin, Michael Ben Ezra
Cellular senescence is a critical component of aging and many age-related diseases, but understanding its role in human health is challenging in part due to the lack of exclusive or universal markers. Using neural networks, we achieve high accuracy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfd21efec8cb974c9500ac0c671f0131
https://doi.org/10.21203/rs.3.rs-1017512/v1
https://doi.org/10.21203/rs.3.rs-1017512/v1
Autor:
Indra Heckenbach, Michael Ben Ezra, Garik V. Mkrtchyan, Jakob Sture Madsen, Malte Hasle Nielsen, Denise Oro, Laust H. Mortensen, Eric Verdin, Rudi G.J. Westendorp, Morten Scheibye-Knudsen
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6971e88e18728d2946e5662dbd6ac39c
https://doi.org/10.2139/ssrn.3821953
https://doi.org/10.2139/ssrn.3821953
Autor:
Garik Mkrtchyan, Brenna Osborne, Michael A. Petr, Malte H. Nielsen, Esben Hartmann, Stella M. Kristensen, Michael Ben Ezra, Charlotte Dresen, Morten Scheibye-Knudsen, Daniela Bakula
Publikováno v:
Osborne, B, Bakula, D, Ben Ezra, M, Dresen, C, Hartmann, E, Kristensen, S M, Mkrtchyan, G V, Nielsen, M H, Petr, M A & Scheibye-Knudsen, M 2020, ' New methodologies in ageing research ', Ageing Research Reviews, vol. 62, 101094 . https://doi.org/10.1016/j.arr.2020.101094
Ageing is arguably the most complex phenotype that occurs in humans. To understand and treat ageing as well as associated diseases, highly specialised technologies are emerging that reveal critical insight into the underlying mechanisms and provide n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cd68a4e127534e2dc198ec35095521
https://curis.ku.dk/portal/da/publications/new-methodologies-in-ageing-research(e349b27c-65c3-4f0f-a75d-af9ef81d1a33).html
https://curis.ku.dk/portal/da/publications/new-methodologies-in-ageing-research(e349b27c-65c3-4f0f-a75d-af9ef81d1a33).html
Autor:
Arnaldur Hall, Morten Scheibye-Knudsen, Scott Maynard, Mansour Akbari, Marya Morevati, Guido Keijzers, Susana Gonzalo, Michael Ben Ezra, Vilhelm A. Bohr, Jiri Bartek
Publikováno v:
Nucleic acids research. 47(22)
The A-type lamins (lamin A/C), encoded by the LMNA gene, are important structural components of the nuclear lamina. LMNA mutations lead to degenerative disorders known as laminopathies, including the premature aging disease Hutchinson-Gilford progeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5d691887c3cd9006fba00e31036a71
https://pubmed.ncbi.nlm.nih.gov/31647095
https://pubmed.ncbi.nlm.nih.gov/31647095
Publikováno v:
Andreassen, S N, Ezra, M B & Scheibye-Knudsen, M 2019, ' A defined human aging phenome ', Aging, vol. 11, no. 15, pp. 5786-5806 . https://doi.org/10.18632/aging.102166
Aging is among the most complex phenotypes that occur in humans. Identifying the interplay between different age-associated features is undoubtedly critical to our understanding of aging and thus age-associated diseases. Nevertheless, what constitute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550b2dfe1e899d6866de02e9e3fc399d
https://pubmed.ncbi.nlm.nih.gov/31408848
https://pubmed.ncbi.nlm.nih.gov/31408848