Výsledky vyhledávání - "Michael Zorniak"

Akademický článek

Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

Autor: Paul A. Clark, Mari Iida, Daniel M. Treisman, Haviryaji Kalluri, Sathyapriya Ezhilan, Michael Zorniak, Deric L. Wheeler, John S. Kuo

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 5, Pp 420-428 (2012)

Epidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GBM) tumorigenesis. However, molecular agents targeting EGFR have demonstrated minimal efficacy in clinical trials, suggesting the existence of GBM resistance m

Externí odkaz: https://doaj.org/article/532e2b057b8e4ce59b1099ff33e191ea

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Akademický článek

Contribution of Alanine-76 and Serine Phosphorylation in α-Synuclein Membrane Association and Aggregation in Yeasts

Autor: Michael Fiske, Stephanie Valtierra, Keith Solvang, Michael Zorniak, Michael White, Sara Herrera, Alina Konnikova, Rebecca Brezinsky, Shubhik DebBurman

Publikováno v: Parkinson's Disease, Vol 2011 (2011)

In Parkinson's disease (PD), misfolded and aggregated α-synuclein protein accumulates in degenerating midbrain dopaminergic neurons. The amino acid alanine-76 in α-synuclein and phosphorylation at serine-87 and serine-129 are thought to regulate it

Externí odkaz: https://doaj.org/article/67ac576bf23a4953ab403646d97514c5

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Supplementary Table 1 from Differential Expression of 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase and Neural Lineage Markers Correlate with Glioblastoma Xenograft Infiltration and Patient Survival

Autor: John S. Kuo, M. Shahriar Salamat, Kevin R. Kozak, David M. Francis, Matthew D. Tipping, Heather E. Leeper, Paul A. Clark, Michael Zorniak

PDF file, 84KB, Antibodies used for western analysis and subclassification of human glioblastoma stem-like cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f52b758030d96d7a4ba80f3cf85f46a
https://doi.org/10.1158/1078-0432.22454990

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Supplementary Table 2 from Differential Expression of 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase and Neural Lineage Markers Correlate with Glioblastoma Xenograft Infiltration and Patient Survival

Autor: John S. Kuo, M. Shahriar Salamat, Kevin R. Kozak, David M. Francis, Matthew D. Tipping, Heather E. Leeper, Paul A. Clark, Michael Zorniak

PDF file, 78KB, Antibodies used for immunohistochemical analysis of human glioblastoma stem-like cell induced mouse xenograft tumors and grade IV astrocytoma tissue microarray.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea60c43e9c75440534b723c66326ffe
https://doi.org/10.1158/1078-0432.22454987.v1

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Supplementary Figure 2 from Differential Expression of 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase and Neural Lineage Markers Correlate with Glioblastoma Xenograft Infiltration and Patient Survival

Autor: John S. Kuo, M. Shahriar Salamat, Kevin R. Kozak, David M. Francis, Matthew D. Tipping, Heather E. Leeper, Paul A. Clark, Michael Zorniak

PDF file, 80KB, Differential neural lineage marker expression associate with survivability of GSC-induced xenografts in immunodeficient mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58f72ff8b1097d582478899f75fc099
https://doi.org/10.1158/1078-0432.22454996.v1

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Data from Differential Expression of 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase and Neural Lineage Markers Correlate with Glioblastoma Xenograft Infiltration and Patient Survival

Autor: John S. Kuo, M. Shahriar Salamat, Kevin R. Kozak, David M. Francis, Matthew D. Tipping, Heather E. Leeper, Paul A. Clark, Michael Zorniak

Purpose: Glioblastoma multiforme (GBM) is a poorly treated human brain cancer with few established clinically useful molecular prognostic markers. We characterized glioblastoma stem–like cells (GSC) according to developmental neural lineage markers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295801bf510f6e3ad81f2d7a792600fd
https://doi.org/10.1158/1078-0432.c.6522893

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Supplementary Figure 1 from Differential Expression of 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase and Neural Lineage Markers Correlate with Glioblastoma Xenograft Infiltration and Patient Survival

Autor: John S. Kuo, M. Shahriar Salamat, Kevin R. Kozak, David M. Francis, Matthew D. Tipping, Heather E. Leeper, Paul A. Clark, Michael Zorniak

PDF file, 327KB, Low and high magnification histology and IHC of differential tumor infiltration in mouse xenografts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccce8122f616df48c7b67aaf8f47f8c3
https://doi.org/10.1158/1078-0432.22454999.v1

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Supplementary Figure Legend from Differential Expression of 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase and Neural Lineage Markers Correlate with Glioblastoma Xenograft Infiltration and Patient Survival

Autor: John S. Kuo, M. Shahriar Salamat, Kevin R. Kozak, David M. Francis, Matthew D. Tipping, Heather E. Leeper, Paul A. Clark, Michael Zorniak

PDF file, 91KB.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c968ee2eba2fd30af268bc93d2987d
https://doi.org/10.1158/1078-0432.22454993.v1

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Myelin-forming cell-specific cadherin-19 is a marker for minimally infiltrative glioblastoma stem-like cells

Autor: John S. Kuo, Paul A. Clark, Michael Zorniak

Publikováno v: Journal of Neurosurgery. 122:69-77

OBJECT Glioblastoma stem-like cells (GSCs) exhibit stem-like properties, are highly efficient at forming tumor xenografts, and are resistant to many current therapies. Current molecular identifiers of GSCs are scarce and controversial. The authors de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec6b20e072eefc7a17aec5b9947de31
https://doi.org/10.3171/2014.9.jns132373

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Yeast display biopanning identifies human antibodies targeting glioblastoma stem-like cells

Autor: John S. Kuo, Paul A. Clark, Yong Ku Cho, Michael Zorniak, Eric V. Shusta, Benjamin J Umlauf

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Glioblastoma stem-like cells (GSC) are hypothesized to evade current therapies and cause tumor recurrence, contributing to poor patient survival. Existing cell surface markers for GSC are developed from embryonic or neural stem cell systems; however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63a7943c54087324c26756789289b16
http://europepmc.org/articles/PMC5696472

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