Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael Zeira"'
Heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantation.
Autor:
Menachem Bitan, Lola Weiss, Michael Zeira, Eyal Zcharia, Shimon Slavin, Arnon Nagler, Israel Vlodavsky
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10135 (2010)
Heparanase, endoglycosidase that cleaves heparan sulfate side chains of heparan sulfate proteoglycans, plays important roles in cancer metastasis, angiogenesis and inflammation.Applying a mouse model of bone marrow transplantation and transgenic mice
Externí odkaz:
https://doaj.org/article/a662c68f2b634fd0ba958fe9b567ab48
Publikováno v:
Biochemistry & Pharmacology: Open Access. 5
A synthetic analog of ceramide (AD2725) elevated ceramide levels in MDA-MB-435 breast cancer cells inducing apoptosis and resulted in cell death. In animal studies, using a model of xenograft breast cancer cancer cells in nude mice, treatment with AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a953494f0a63de6c52b37f18e297072
https://doi.org/10.4172/2167-0501.1000212
https://doi.org/10.4172/2167-0501.1000212
Autor:
Lellean JeBailey, Sivakumar Ramu, Ravi Amunugama, Zhanna Yekhtin, Osnat Almogi-Hazan, Israel Reibstein, Lola Weiss, Reuven Or, Alexander O. Vortmeyer, Michael Zeira, Eytan R. Barnea, Richard C. Jones, Steven A. Bernstein, Reut Shainer, Shimon Slavin, Michael J. Paidas
Publikováno v:
Journal of the Neurological Sciences. 312:146-157
Introduction Embryo-derived PIF modulates systemic maternal immunity without suppression. Synthetic analog (sPIF) prevents juvenile diabetes, preserves islet function, reducing oxidative stress/protein misfolding. We investigate sPIF effectiveness in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50c38e6a7d5fa2d805cddb408856bba
https://doi.org/10.1016/j.jns.2011.07.050
https://doi.org/10.1016/j.jns.2011.07.050
Autor:
Lola Weiss, Eyal Zcharia, Shimon Slavin, Menachem Bitan, Israel Reibstein, Yakov Fellig, Arnon Nagler, Michael Zeira, Israel Vlodavsky
Publikováno v:
Molecular Immunology. 47:1890-1898
Heparanase is an endo-beta-d-glucuronidase that cleaves heparan sulfate (HS) saccharide chains. The enzyme promotes cell adhesion, migration and invasion and plays a significant role in cancer metastasis, angiogenesis and inflammation. The present st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dfc17b746eaf8ce2170052f61df554
https://doi.org/10.1016/j.molimm.2010.03.014
https://doi.org/10.1016/j.molimm.2010.03.014
Publikováno v:
Leukemia Research. 33:525-538
The breaking of peripheral T-cell tolerance toward self-antigens expressed by tumor cells and the subsequent establishment of an effective tumor protective immune response remains a major challenge for cancer immunotherapy. We report that both protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf740524908a93767975e732ab8bbe5
https://doi.org/10.1016/j.leukres.2008.08.017
https://doi.org/10.1016/j.leukres.2008.08.017
Publikováno v:
Leukemia Research. 32:1903-1913
Fully allogeneic CD3/CD28 cross-linked Th1 cells were found to elicit host-mediated anti-leukemia effects without GVHD toxicity. Mice inoculated with a lethal dose of BCL1 leukemia demonstrated significantly enhanced survival after allogeneic Th1 tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56692b855523cd56699f6e6a3750ba7
https://doi.org/10.1016/j.leukres.2008.05.007
https://doi.org/10.1016/j.leukres.2008.05.007
Autor:
Shimon Slavin, Shoshana Reich, Orit Pappo, Lola Weiss, Menachem Bitan, Michael Zeira, Israel Vlodavsky
Publikováno v:
Diabetes/Metabolism Research and Reviews. 24:413-421
Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate saccharide chains. The enzyme promotes cell adhesion, migration and invasion, and was shown to play a significant role in cancer metastasis and angiogenesis.The present study foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2885d54b5e015e7769add773b58cb023
https://doi.org/10.1002/dmrr.868
https://doi.org/10.1002/dmrr.868
Autor:
Raphael Mechoulam, Lola Weiss, Shimon Slavin, Michael Zeira, Itamar Raz, Shoshana Reich, Ruth Gallily
Publikováno v:
Neuropharmacology. 54:244-249
We have previously reported that cannabidiol (CBD) lowers the incidence of diabetes in young non-obese diabetes-prone (NOD) female mice. In the present study we show that administration of CBD to 11-14 week old female NOD mice, which are either in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f0a6a8340fca407ed6726f32e9bdf8
https://doi.org/10.1016/j.neuropharm.2007.06.029
https://doi.org/10.1016/j.neuropharm.2007.06.029
Publikováno v:
Bone Marrow Transplantation. 38:359-364
Although the use of non-myeloablative stem cell transplantation (NST) reduces the severity of graft-versus-host disease (GVHD), GVHD remains a major complication following allogeneic transplantation. Since following NST in comparison with myeloablati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52798addc0ef74449e54ea54fea504cb
https://doi.org/10.1038/sj.bmt.1705449
https://doi.org/10.1038/sj.bmt.1705449
Autor:
Lola Weiss, Michael Y. Shapira, Shimon Slavin, Ester Hirshfeld, Judith Kasir, Reuven Or, Igor B. Resnick, Michael Zeira
Publikováno v:
Cancer Immunology, Immunotherapy. 54:383-388
Background: Graft-versus-leukemia (GVL) effect is an essential component in the course of allogeneic stem cell transplantation (SCT). However, both prevention and treatment of established graft-versus-host disease (GVHD), including with drugs such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a1d42f43c105ccf961f707dcac2926
https://doi.org/10.1007/s00262-004-0614-9
https://doi.org/10.1007/s00262-004-0614-9