Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michael Zakrewsky"'
Autor:
Daniel Pan, Omayra Vargas-Morales, Blaine Zern, Aaron C Anselmo, Vivek Gupta, Michael Zakrewsky, Samir Mitragotri, Vladimir Muzykantov
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152074 (2016)
Red blood cells (RBCs) can be used for vascular delivery of encapsulated or surface-bound drugs and carriers. Coupling to RBC prolongs circulation of nanoparticles (NP, 200 nm spheres, a conventional model of polymeric drug delivery carrier) enabling
Externí odkaz:
https://doaj.org/article/84781a3db4834519b1014695f0e05100
Autor:
Michael Zakrewsky, Patrick Hoopes
Publikováno v:
Journal of Pharmaceutical Sciences. 111:382-394
Sterilizing filtration is a common unit operation for the manufacture of parenteral drug products. However, filter performance can be impacted by properties of both the membrane material and the solution being filtered, requiring extensive multi-fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f19535baff101da15637e2eb6172b17
https://doi.org/10.1016/j.xphs.2021.09.039
https://doi.org/10.1016/j.xphs.2021.09.039
Autor:
Dan Davis, Khaled AboulFotouh, Donna M. Williams, Mohammed Maniruzzaman, Yajie Zhang, Jieliang Wang, Michael Zakrewsky, Robert O. Williams, Akhilesh Bhambhani, Zhengrong Cui
Publikováno v:
Advanced drug delivery reviews. 172
Recent advances in formulation sciences have expanded the previously limited design space for biological modalities, including peptide, protein, and vaccine products. At the same time, the discovery and application of new modalities, such as cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9d85c9f5d83e1d1b7053f7719b3aa6
https://pubmed.ncbi.nlm.nih.gov/33705873
https://pubmed.ncbi.nlm.nih.gov/33705873
Autor:
Michael Zakrewsky, Samir Mitragotri
Publikováno v:
Journal of Controlled Release. 242:80-88
The high prevalence of skin diseases and their visible symptoms result in major physical, emotional, and economic burden for which few solutions exist. To address this unmet medical need, topical delivery of RNAi such as siRNA holds many advantages i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104d427406e26b308b5f1b3b4cee2f22
https://doi.org/10.1016/j.jconrel.2016.09.003
https://doi.org/10.1016/j.jconrel.2016.09.003
Autor:
Sanjana Apte, Michael Zakrewsky, Amrita Banerjee, David T. Fox, Mattie R. Jones, Andrew T. Koppisch, Rico E. Del Sesto, Theresa L. Kern, Samir Mitragotri
Publikováno v:
Advanced Healthcare Materials. 5:1282-1289
Antiseptic agents are the primary arsenal to disinfect skin and prevent pathogens spreading within the host as well as into the surroundings; however the Food and Drug Administration published a report in 2015 requiring additional validation of nearl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d3ff25156f9d8cff76ba17254a1053
https://doi.org/10.1002/adhm.201600086
https://doi.org/10.1002/adhm.201600086
Publikováno v:
Regenerative Engineering and Translational Medicine. 2:23-36
Keratinocytes are a targeted cell-type for treating skin disease. However, delivering drugs into the skin and keratinocytes remains challenging due to transport barriers posed by both the stratum corneum and cell membrane. Nonetheless, SPACE™ pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0bb392e4d44e8cca6506edc69292d44
https://doi.org/10.1007/s40883-016-0011-x
https://doi.org/10.1007/s40883-016-0011-x
Publikováno v:
Journal of Controlled Release. 220:141-148
The immune system has evolved to recognize and respond to a wide variety of pathogens and produce distinct immune responses against diverse pathogenic structures. Despite remarkable advances, the general mechanisms by which the immune system differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bf8144fd68bdde209a77334838f478
https://doi.org/10.1016/j.jconrel.2015.09.069
https://doi.org/10.1016/j.jconrel.2015.09.069
Publikováno v:
TECHNOLOGY. :214-238
Oral propranolol is commonly the first-line treatment of infantile hemangioma. However, oral delivery of propranolol is limited by systemic side effects, particularly in infants. Topical application may be a more patient friendly alternative while co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adcf22ed0059e0867e685d55cf0a4e81
https://doi.org/10.1142/s2339547815500107
https://doi.org/10.1142/s2339547815500107
Autor:
Samir Mitragotri, Sunny Kumar, Joshua Sanchez De Oliveira, Michael Zakrewsky, Nino Ruocco, Stefano Menegatti, Gary L. Leal, Matthew E. Helgeson
Publikováno v:
Advanced Healthcare Materials. 4:2297-2305
Combinations of polymer conjugates affording in situ gelation hold promise for treatment of pathological cavities (e.g., arthritis) and sustained drug release. In particular, hyaluronic acid (HA) functionalized with reactive groups is regarded as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f80c478a1ba2bfc702bf2d8d66efc6
https://doi.org/10.1002/adhm.201500619
https://doi.org/10.1002/adhm.201500619
Autor:
Michael Zakrewsky, John A. Muraski, Sunny Kumar, Ming Chen, Samir Mitragotri, Stefano Menegatti
Publikováno v:
Journal of Controlled Release. 199:168-178
Skin penetrating peptides (SPPs) have garnered wide attention in recent years and emerged as a simple and effective noninvasive strategy for macromolecule delivery into the skin. Although SPPs have demonstrated their potential in enhancing skin deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051bac326f55b80b4bdf0339a6d89f74
https://doi.org/10.1016/j.jconrel.2014.12.006
https://doi.org/10.1016/j.jconrel.2014.12.006