Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Michael Z. Cicha"'
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Hypertension is regulated by immunological components. Spontaneously hypertensive rats (SHR) display a large population of proinflammatory CD161 + immune cells. We investigated the effect of early post-natal gut microbiota on the development of the i
Externí odkaz:
https://doaj.org/article/9f586fd299004aa5b58760fd052fb563
Autor:
Michael Z. Cicha, David K. Meyerholz, Madhu V. Singh, Mark W. Chapleau, Francois M. Abboud, Sarah Nunez
Publikováno v:
Am J Physiol Heart Circ Physiol
Toll-like receptors (TLR) are key components of the innate immune system that elicit inflammatory responses through the adaptor proteins myeloid differentiation protein 88 (MyD88) and Toll-interleukin receptor domain-containing adaptor protein-induci
Publikováno v:
The FASEB Journal. 33
Autor:
Christopher J. Benson, Michael Z. Cicha, Francois M. Abboud, Mark W. Chapleau, Christopher J. Madden, Madhu V. Singh, Runping Wang, Yongjun Lu
The satiety effects and metabolic actions of cholecystokinin (CCK) have been recognized as potential therapeutic targets in obesity for decades. We identified a potentially novel Ca(2+)-activated chloride (Cl(–)) current (CaCC) that is induced by C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1888b992126768dc2b0ff75b1a888a45
https://europepmc.org/articles/PMC6483506/
https://europepmc.org/articles/PMC6483506/
Publikováno v:
The FASEB Journal. 34:1-1
Publikováno v:
Hypertension. 72
High fat diet (HFD) leads to obesity and the metabolic syndrome. However, the effect are less pronounced in females than in males. We suggest that a gender difference is in their response to the satiety peptide Cholecystokinin (CCK). We previously re
Publikováno v:
The FASEB Journal. 32
Autor:
Oliver Domenig, Michael Z. Cicha, Mark W. Chapleau, Rasna Sabharwal, Kathy Zimmerman, Robert M. Weiss
Publikováno v:
Experimental Physiology. 100:776-795
New Findings What is the central question of this study? Is autonomic dysregulation in a mouse model of muscular dystrophy dependent on left ventricular systolic dysfunction and/or activation of the renin–angiotensin system (RAS) and does it predic
Autor:
Christopher J. Benson, Runping Wang, Yongjun Lu, Francois M. Abboud, Mark W. Chapleau, Michael Z. Cicha
Publikováno v:
Hypertension. 70
Cholecystokinin (CCK) is a well-known satiety peptide that inhibits food intake. The CCK induced satiety signal in intestinal vagal afferents is attenuated in mice on a High Fat Diet (HFD). We have shown that down regulation of a Ca 2+ -activated Cl
Publikováno v:
Hypertension. 70
The innate immune system plays a key role in onset and maintenance of hypertension. We showed that the toll-like receptor (TLR) adaptor protein TRIF (toll interleukin receptor domain-containing adaptor-inducing interferon-b), but not MyD88 (myeloid d