Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michael Z Michael"'
Autor:
Sina Vatandoust, David Wattchow, Luigi Sposato, Michael Z Michael, John Leung, Kirsten Gormly, Gang Chen, Erin L. Symonds, Jeanne Tie, Lito Electra Papanicolas, Susan Woods, Val Gebski, Kelly Mead, Aleksandra Kuruni, Christos S. Karapetis
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Rectal Cancer is a common malignancy. The current treatment approach for patients with locally advanced rectal cancer involves neoadjuvant chemoradiotherapy followed by surgical resection of the rectum. The resection can lead to c
Externí odkaz:
https://doaj.org/article/5dc3a87f276248a3a9f3c963a4dd1af3
Autor:
Liam M. Ashander, Amanda L. Lumsden, Yuefang Ma, Alwin Chun Rong Tan, Binoy Appukuttan, Santhosh Daniel, Michael Z. Michael, Justine R. Smith
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
As a key host protein involved in cellular infection by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), angiotensin converting enzyme (ACE)2 is an ideal target for antiviral drugs. Manipulation of transcription provides opportunity fo
Externí odkaz:
https://doaj.org/article/69961812c22a4d75ba5b7c5364291f7d
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112288 (2014)
The miR-17-92 cluster of microRNAs is elevated in colorectal cancer, and has a causative role in cancer development. Of the six miR-17-92 cluster members, miR-19a and b in particular are key promoters of cancer development and cell proliferation, whi
Externí odkaz:
https://doaj.org/article/e25690a03c37427bbb9006fa9286db5c
Autor:
Alwin Chun Rong Tan, Yuefang Ma, Binoy Appukuttan, Karen Lower, Amanda L. Lumsden, Michael Z. Michael, Justine R. Smith, Liam M. Ashander
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
Intercellular adhesion molecule 1 (ICAM-1) is a central cell adhesion molecule for retinal transendothelial migration of the leukocytes in non-infectious posterior uveitis. Inhibiting ICAM1 gene transcription reduces induction of ICAM-1 in inflamed r
Externí odkaz:
https://doaj.org/article/312c829ffc5e437999c2ad334b0b61ea
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
This scoping review identifies the mechanistic pathways of metformin when used to treat head and neck cancer cells, in the pre-clinical setting. Understanding the underlying mechanisms will inform future experimental designs exploring metformin as a
Externí odkaz:
https://doaj.org/article/e4361bca5342418ebf64a57fda4303b9
Autor:
Elise J. Tucker, Soon Wei Wong, Shashikanth Marri, Saira Ali, Anthony O. Fedele, Michael Z. Michael, Darling Rojas-Canales, Jordan Y. Li, Chuan Kok Lim, Jonathan M. Gleadle
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108719- (2024)
Summary: Many viruses produce microRNAs (miRNAs), termed viral miRNAs (v-miRNAs), with the capacity to target host gene expression. Bioinformatic and cell culture studies suggest that SARS-CoV-2 can also generate v-miRNAs. This patient-based study de
Externí odkaz:
https://doaj.org/article/8300473334884e48939e9b907a2b0462
Autor:
Saira R. Ali, Karen J. Humphreys, Kaylene.J. Simpson, Ross A. McKinnon, Robyn Meech, Michael Z. Michael
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 30-47 (2022)
The gut fermentation product butyrate displays anti-cancer properties in the human proximal colon, including the ability to inhibit proliferation and induce apoptosis in colorectal cancer (CRC) cells. A natural histone deacetylase inhibitor (HDACi),
Externí odkaz:
https://doaj.org/article/c9d3f06c95044ce5a87a26b56e3eec3e
Autor:
Kaitlin R. Morrison, Tingting Wang, Kuan Yoow Chan, Eleanor W. Trotter, Ari Gillespie, Michael Z. Michael, Jonathan S. Oakhill, Iain M. Hagan, Janni Petersen
Publikováno v:
Open Biology, Vol 13, Iss 4 (2023)
Expression and activity of the AMP-activated protein kinase (AMPK) α1 catalytic subunit of the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer patients. Hence there is considerable interest in uncovering signal
Externí odkaz:
https://doaj.org/article/8f517fb0f4714e258cf9dc1d821f5c08
Autor:
Pamela J. Sykes, Karen M. Lower, Michael Z. Michael, Rebecca J. Ormsby, Katherine L. Morel, Margaret M. Centenera, Lisa M. Butler, Ganessan Kichenadasse, Linh N.K. Tran
Legends of supplementary Figure S1, S2, S3, S4, and S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584ca8dcceed6ff38e64b980fd1cadf9
https://doi.org/10.1158/1535-7163.22509328.v1
https://doi.org/10.1158/1535-7163.22509328.v1
Autor:
Pamela J. Sykes, Karen M. Lower, Michael Z. Michael, Rebecca J. Ormsby, Katherine L. Morel, Margaret M. Centenera, Lisa M. Butler, Ganessan Kichenadasse, Linh N.K. Tran
S1: Comparison of the Incucyte FLR and Operetta High Content Imaging System for detection of apoptosis in PC-3 cells induced by Paclitaxel. S2: Nuclear fragmentation index of PC-3 cells in the presence and absence of ectopically expressed p53 in resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45bebf94f21d7419116501156db2ecf
https://doi.org/10.1158/1535-7163.22509325
https://doi.org/10.1158/1535-7163.22509325