Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael Youngman"'
Autor:
T. Torvela, P. Zoriy, B. Bravo, A. Pántya, I. Vu, G. Taba, J. Brose, G. Lünendonk, David Broggio, A. L. Lebacq, Oliver Meisenberg, Michael Youngman, M. Takahashi, D. Franck, L. Csizmadia, I. Vilardi, D. Saurat, J. Osko, M. A. Saizu, J. Kövendiné-Kónyi, N. Mosimann, T. Beaumont, P. Fojtík, Z. Vagfoldi, Mats Isaksson
Publikováno v:
Radiation Measurements
Radiation Measurements, Elsevier, 2019, 129, pp.106178. ⟨10.1016/j.radmeas.2019.106178⟩
Radiation Measurements, Elsevier, 2019, 129, pp.106178. ⟨10.1016/j.radmeas.2019.106178⟩
International audience; In case of a nuclear reactor accident affecting a large population the internal contamination of the workers and the public can be assessed through in vivo measurements. Since iodine-131 is one of the most important releases a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf77ee0b3e9126bf6cfa65b90c0b9c3
https://hal.archives-ouvertes.fr/hal-02527501
https://hal.archives-ouvertes.fr/hal-02527501
Autor:
Amanda Mathis, Wenyan Mo, Susan Long, Stephanie Anna Chan, Jill Walker, Ryan Lauchli, Martin Robert Leivers, Elizabeth M. Turner, Tony Ton, Sebastian Liehr, J. Greg Falls, John F. Miller, Michael Youngman
Publikováno v:
Journal of Medicinal Chemistry. 57:1964-1975
By reducing the basicity of the core heterocycle in a series of HCV NS5B inhibitors, the hERG liability was reduced. The SAR was then systematically explored in order to increase solubility and enable dose escalation while retaining potency. During t
Autor:
Andrew J. Peat, Kurt Weaver, Liping Wang, Sebahar Paul Richard, Eugene L. Stewart, Amanda Mathis, Robert T. Nolte, Dulce Garrido, Robert G. Ferris, Mark P. Edelstein, Huichang Zhang, Pek Yoke Chong, Michael Youngman
Publikováno v:
Journal of Medicinal Chemistry. 55:10601-10609
A new series of non-nucleoside reverse transcriptase inhibitors based on an imidazole-amide biarylether scaffold has been identified and shown to possess potent antiviral activity against HIV-1, including the NNRTI-resistant Y188L mutated virus. X-ra
Autor:
Terry P. Kenakin, Robert G. Ferris, Christopher Joseph Aquino, Pat Wheelan, Michael Youngman, Chris Watson, Cecilia S. Koble, Maosheng Duan, Wieslaw M. Kazmierski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1610-1613
Several series of CCR5 antagonists have been discovered by derivatization at the N-terminal of the piperidine ring of the core template 2. Some derivatives exhibited potent inhibition against HIV-1infection. The pharmacokinetic properties of the lead
Autor:
Pat Wheelan, Brian A. Chauder, Christian Watson, Terrence Peter Kenakin, Robert M. Ferris, Cecilia S. Koble, Deborah K. Jones-Hertzog, Michael Youngman, Hanbiao Yang, Christopher J Aquino, Felix Deanda, Wieslaw M. Kazmierski
Publikováno v:
Journal of Medicinal Chemistry. 51:6538-6546
We describe robust chemical approaches toward putative CCR5 scaffolds designed in our laboratories. Evaluation of analogues in the (125)I-[MIP-1beta] binding and Ba-L-HOS antiviral assays resulted in the discovery of 64 and 68 in the 4,4-disubstitite
Autor:
Michael Youngman
Publikováno v:
Journal of radiological protection : official journal of the Society for Radiological Protection. 35(2)
In the event of a radiation emergency, people close to the site of the incident may be exposed to radiation by external exposure, or as a result of intakes of radioactive material. For these incidents it may be necessary to monitor members of the pub
Autor:
H. Wershofen, J. L. Gascón, Y. Bourlat, M. Magnoni, M.J. Woods, Michael Youngman, D. Andrew, J. Desmond, G. Sutton, P. De Felice, Aldo Fazio, D. S. Popplewell, R. S. Grieve, R. Bojanowski, A. R. Byrne, Dirk Arnold, K. J. Odell, Simon Jerome, I. Adsley, A. S. Holmes, M.T. Crespo, I. Poupaki, M. W. Wakerley, J. Toole, M. Korun
Publikováno v:
Applied Radiation and Isotopes. 49:1295-1300
The characterisation of an intertidal sediment, containing enhanced levels of radioactivity, collected from the Cumbrian coast of the U.K. by the Laboratory of the Government Chemist for the Department of the Environment is described. A wide variety
Autor:
John W. Seal, Dan Todd, Banka Anna L, Luz H. Carballo, Zhiping Xiong, Lisa L. Stroup, Amanda Mathis, Zhi Hong, Jeffery J. Pouliot, Pek Yoke Chong, Michael Youngman, Robert Hamatake, Daniel J. Price, Jing Fang, Katrina L. Creech, Andrew Spaltenstein, John G. Catalano, Christopher Don Roberts, J. Brad Shotwell, Andrew J. Peat, Vincent W.-F. Tai, John F. Miller, Sylvia Furst, Huichang Zhang
Publikováno v:
Journal of medicinal chemistry. 57(5)
We describe the preclinical development and in vivo efficacy of a novel chemical series that inhibits hepatitis C virus replication via direct interaction with the viral nonstructural protein 4B (NS4B). Significant potency improvements were realized
Autor:
Michael Youngman
Publikováno v:
Research Papers in Education. 9:369-410
Contract researchers comprise a substantial element in all areas of academic research, but numerous reports have exposed major concerns over status, security and conditions. As part of a larger review of its research activities, the ESRC in 1991 comm
Autor:
Jennifer Poole Peckham, Don L. Anderson, Christian Watson, Brian Andrew Chauder, Michael Youngman, Terrence Peter Kenakin, Maggie S. McIntyre, Maosheng Duan, Wieslaw M. Kazmierski, Robert G. Ferris, Andrew Spaltenstein, Pat Wheelan, Christopher Joseph Aquino, Cecilia S. Koble, Dan G. Lang, Mary Beth Wire, Angilique Svolto
Publikováno v:
Journal of medicinal chemistry. 54(11)
We recently described ( J. Med. Chem. 2008 , 51 , 6538 - 6546 ) a novel class of CCR5 antagonists with strong anti-HIV potency. Herein, we detail SAR converting leads 1 and 2 to druglike molecules. The pivotal structural motif enabling this transitio