Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Michael Y. Sherman"'
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104282- (2022)
Summary: The major heat shock protein Hsp70 forms a complex with a scaffold protein Bag3 that links it to components of signaling pathways. Via these interactions, the Hsp70-Bag3 module functions as a proteotoxicity sensor that controls cell signalin
Externí odkaz:
https://doaj.org/article/021bb55495c44bed9de9b51517af3f0b
Autor:
Eleonora Ela Hezkiy, Santosh Kumar, Valid Gahramanov, Julia Yaglom, Arkadi Hesin, Suchita Suryakant Jadhav, Ekaterina Guzev, Shivani Patel, Elena Avinery, Michael A. Firer, Michael Y. Sherman
Publikováno v:
Cells, Vol 11, Iss 22, p 3671 (2022)
Finding synergistic drug combinations is an important area of cancer research. Here, we sought to rationally design synergistic drug combinations with an inhibitor of BTK kinase, ibrutinib, which is used for the treatment of several types of leukemia
Externí odkaz:
https://doaj.org/article/70675f1f639c4b039c8db444af46edd2
Autor:
Valid Gahramanov, Moria Oz, Tzemach Aouizerat, Tovit Rosenzweig, Jonathan Gorelick, Elyashiv Drori, Mali Salmon-Divon, Michael Y. Sherman, Bat Chen R. Lubin
Publikováno v:
Plants, Vol 11, Iss 17, p 2195 (2022)
Medicinal properties of plants are usually identified based on knowledge of traditional medicine or using low-throughput screens for specific pharmacological activities. The former is very biased since it requires prior knowledge of plants’ propert
Externí odkaz:
https://doaj.org/article/8e99c5802ff5411898f834b1a537dc70
Autor:
Ekaterina Guzev, Suchita Suryakant Jadhav, Eleonora Ela Hezkiy, Michael Y. Sherman, Michael A. Firer, Svetlana Bunimovich-Mendrazitsky
Publikováno v:
Cells, Vol 11, Iss 15, p 2325 (2022)
In recent years, mathematical models have developed into an important tool for cancer research, combining quantitative analysis and natural processes. We have focused on Chronic Lymphocytic Leukemia (CLL), since it is one of the most common adult leu
Externí odkaz:
https://doaj.org/article/7797f6065d634a97a377899707ec1521
Autor:
Julia A. Yaglom, Yongmei Wang, Amy Li, Zhenghu Li, Stephano Monti, Ilya Alexandrov, Xiongbin Lu, Michael Y. Sherman
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Externí odkaz:
https://doaj.org/article/c99698d2e6be46d5ae1dcb53cb388aa4
Publikováno v:
The Scientific World Journal, Vol 1, Pp 36-36 (2001)
Externí odkaz:
https://doaj.org/article/f6a8b1a76d3d453c859b880a7a87bbcc
Autor:
Yuemeng Wang, Qile Zhu, Shiya Guo, Juan Ao, Wenhua Zhang, Junjie Fei, Shuhan Yu, Mengmeng Niu, Yujun Zhang, Michael Y. Sherman, Zhi‐Xiong Jim Xiao, Yong Yi
Publikováno v:
FEBS Letters. 597:1125-1137
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df57d2cb7abbbc65f51f4c1f7fa78f6a
https://doi.org/10.1002/1873-3468.14588
https://doi.org/10.1002/1873-3468.14588
Autor:
Ivan Alexandrov, Mali Salmon-Divon, Lukasz Kaczmarczyk, Santosh Kumar, Patel Shivani, Gabi Gerlitz, Michael Y. Sherman, Valid Gahramanov, Julia Yaglom
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 10; Pages: 8717
Resistance to chemotherapy is a leading cause of treatment failure. Drug-resistance mechanisms involve mutations in specific proteins or changes in their expression levels. It is commonly understood that resistance mutations happen randomly prior to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6859b136e075548f72940354e5baaea9
Autor:
Jason E. Gestwicki, Michael Y. Sherman, Jonathan S. Weissman, Peter Walter, Min Cho, Megan Murnane, Blake T. Aftab, Byron Hann, Bryan Dunyak, Martin Kampmann, Diego Acosta-Alvear, Jennifer N. Rauch, Teresa Colvin, Xiaokai Li
Hsp70 is a stress-inducible molecular chaperone that is required for cancer development at several steps. Targeting the active site of Hsp70 has proven relatively challenging, driving interest in alternative approaches. Hsp70 collaborates with the Bc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd8b5bdb678ea6e4e4a7279ed92a4f0
https://doi.org/10.1158/1535-7163.c.6537132
https://doi.org/10.1158/1535-7163.c.6537132
Autor:
Jason E. Gestwicki, Michael Y. Sherman, Jonathan S. Weissman, Peter Walter, Min Cho, Megan Murnane, Blake T. Aftab, Byron Hann, Bryan Dunyak, Martin Kampmann, Diego Acosta-Alvear, Jennifer N. Rauch, Teresa Colvin, Xiaokai Li
Supplemental Figures 1-4. Supplemental Figure 1. Chemical structures of the compounds used in this study and characterization of JG98-biotin by NMR and MS/MS; Supplemental Figure 2. JG-98 disrupts the Hsp70-Bag interaction in HeLa cells; Supplemental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a6fe54fec661425a329720a85dd84e
https://doi.org/10.1158/1535-7163.22502598
https://doi.org/10.1158/1535-7163.22502598