Membrane disruption, but not metabolic rewiring, is the key mechanism of anticancer-action of FASN-inhibitors: a multi-omics analysis in ovarian cancer

Autor: Thomas W. Grunt, Gerald Stübiger, Renate Wagner, Mariya Semkova, Ramon Colomer, Michael Wuczkowski, Astrid Slany, Christopher Gerner, María L. López-Rodríguez

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-28 (2020)
Repisalud
Instituto de Salud Carlos III (ISCIII)

Fatty-acid(FA)-synthase(FASN) is a druggable lipogenic oncoprotein whose blockade causes metabolic disruption. Whether drug-induced metabolic perturbation is essential for anticancer drug-action, or is just a secondary-maybe even a defence response-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb30aad613d6b68f1b576f21ecded11e
http://europepmc.org/articles/PMC7483762

MALDI-MS Protein Profiling of Chemoresistance in Extracellular Vesicles of Cancer Cells

Autor: Robert M. Mader, Tom K Abban, Michael Wuczkowski, Luis Mancera, Michael D Nairn, Matthew E. Openshaw, Gerald Stübiger, Daniel Senfter, Barbara Herzig

Publikováno v: Analytical chemistry. 90(22)

Cancer cells communicate with the whole organism via extracellular vesicles (EVs), which propagate molecular information in support of the malignant phenotype. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b345b5ef4ff424f79aebef541169fe41
https://pubmed.ncbi.nlm.nih.gov/31531772

Nanoparticle-Based Detection of Oxidized Phospholipids by MALDI Mass Spectrometry: Nano-MALDI Approach

Autor: Gerald Stübiger, Michael Wuczkowski, Omar Belgacem, Wolfgang Bicker

Publikováno v: Analytical Chemistry. 86:6401-6409

In this paper we present a pioneering approach exploiting nanoparticles (NPs) for the "on-probe" (i.e., directly from the NP-surface) monitoring of OxPLs by MALDI-MS (i.e., the Nano-MALDI approach). The "electrophilic interaction" with either metal o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33c414df6fdeab8277d7c334b666fba
https://doi.org/10.1021/ac500719u

Description of Holtermanniella gen. nov., including Holtermanniella takashimae sp. nov. and four new combinations, and proposal of the order Holtermanniales to accommodate tremellomycetous yeasts of the Holtermannia clade

Autor: Bart Theelen, Arja Laitila, Pietro Buzzini, Diego Libkind, Ann-Christin Andersson, María van Broock, Benedetta Turchetti, Michael Wuczkowski, Teun Boekhout, Volkmar Passoth, Matilda Olstorpe, Johan Schnürer, Hansjörg Prillinger, Katja Sterflinger

Publikováno v: International Journal of Systematic and Evolutionary Microbiology, 61, 680-689. Society for General Microbiology
Wuczkowski, M, Passoth, V, Turchetti, B, Andersson, A-C, Olstorpe, M, Laitila, A, Theelen, B, van Broock, M, Buzzini, P, Prillinger, H, Sterflinger, K, Schnürer, J, Boekhout, T & Libkind, D 2010, ' Description of Holtermanniella gen. nov., including Holtermanniella takashimae sp. nov. and four new combinations, and proposal of the order Holtermanniales to accommodate tremellomycetous yeasts of the Holtermannia clade ', International Journal of Systematic and Evolutionary Microbiology, vol. 61, no. 3, pp. 680-689 . https://doi.org/10.1099/ijs.0.019737-0

The novel genus Holtermanniella is proposed here to accommodate four Cryptococcus species closely related to Holtermannia corniformis that are included in the Holtermannia clade (Basidiomycota, Agaricomycotina). Thus, four novel combinations are prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c7b076fab811787fac0647c0de1fb8
https://doi.org/10.1099/ijs.0.019737-0

Yeast biodiversity in the guts of several pests on maize; comparison of three methods: classical isolation, cloning and DGGE

Autor: Hansjörg Prillinger, Orsolya Molnár, Michael Wuczkowski

Publikováno v: Mycological Progress. 7:111-123

The yeast biodiversity in the guts of several pests (Diabrotica virgifera, Helicoverpa armigera, Ostrinia nubilalis) on maize from two isolation sources was assessed by cultivation-dependent and cultivation-independent methods. These yeasts are consi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fb1d48264fbb5c6e4e3de9451fd1113
https://doi.org/10.1007/s11557-008-0558-0